[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641679":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":57,"collaborators":24,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":24,"enrollmentInfo":68,"targetDuration":24,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Institute of Gastroenterology and Hepatology, Vietnam","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ecologic Barrier First-Month Sequence","EXPERIMENTAL","This group included IBS-D patients who were prescribed a standard 2-month treatment regimen and received the study product as an add-on therapy during the first month.",[13],"Dietary Supplement: Ecologic Barrier",{"label":15,"type":10,"description":16,"interventionNames":17},"Ecologic Barrier Second-Month Sequence","This group included IBS-D patients who were prescribed a standard 2-month treatment regimen and received the study product as an add-on therapy during the second month.",[13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","Ecologic Barrier","Ecologic Barrier will be added to the standard treatment regimen during the first month of treatment.",[9],null,{"type":20,"name":21,"description":26,"armGroupLabels":27,"otherNames":24},"Ecologic Barrier will be added to the standard treatment regimen during the second month of treatment.",[15],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Hang V Dao, PhD","CONTACT","+84 987988075","hangdao.fsh@gmail.com",{"name":35,"role":31,"phone":36,"phoneExt":24,"email":37},"Thuong T Nguyen, Bachelor","+84 983164220","thuongnt.huph@gmail.com",[39],{"facility":40,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Institute of Gastroenterology and Hepatology","RECRUITING","Hanoi","10000","Vietnam","VN",{"type":47,"coordinates":48},"Point",[49,50],105.84117,21.0245,{"lat":50,"lon":49},[53,54,55],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},{"name":35,"role":31,"phone":36,"phoneExt":24,"email":37},{"name":30,"role":56,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"type":58,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100641679","effects-of-the-multispecies-probiotic-ecologic-barrier-in-ibs-patients-with-upper-gi-symptoms-and-anxiety-depression-or-stress-100641679",false,"NCT07656623","Effects of the Multispecies Probiotic Ecologic Barrier in IBS Patients With Upper GI Symptoms and Anxiety, Depression, or Stress","The Effects of the Multispecies Probiotic Mixture Ecologic Barrier for Patients With Irritable Bowel Syndrome With Upper Gastrointestinal Symptoms and Having Anxiety, Depression, and Stress Symptoms","Inclusion Criteria:\n\n* Indication for upper endoscopy and colonoscopy;\n* Diagnosed with IBS-D according to Rome IV criteria;\n* Presence of at least one upper gastrointestinal symptom, including: retrosternal burning, reflux, epigastric pain, epigastric burning, postprandial discomfort, early satiety, abdominal bloating, belching, sour regurgitation, nausea\u002Fvomiting;\n* Manifestations of anxiety, depression, or stress, with at least one of the three DASS-21 subscale scores exceeding the normal threshold (depression score \\>9 and\u002For anxiety score \\>7 and\u002For stress score \\>14).\n\nExclusion Criteria:\n\n* Positive for Helicobacter pylori by rapid urease test during endoscopy or by 13C-urea breath test;\n* Currently using anxiolytic or antidepressant medication;\n* Currently or previously used antibiotics within the past month;\n* Currently or previously used symptomatic treatment, probiotics, or proton pump inhibitors (PPI) within the past two weeks;\n* History of gastrointestinal surgery;\n* Endoscopic findings of organic lesions: ulcer, acute inflammation, colonic polyp \\>5 mm, or colonic polyp \\\u003C5 mm with suspected neoplasia;\n* Pregnant or breastfeeding women.","ALL","18 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The aim of this clinical trial is to find out whether Ecologic Barrier is effective in supporting the treatment of irritable bowel syndrome (IBS) in adults. The main questions that this trial aims to answer are:\n\n* Does Ecologic Barrier help improve IBS severity when added to standard IBS treatment?\n* Does Ecologic Barrier help improve symptoms of anxiety, depression, and stress in patients with IBS?\n* Does Ecologic Barrier help improve upper gastrointestinal symptoms when added to standard IBS treatment?\n* What adverse events may occur when using Ecologic Barrier? The researchers will compare a group receiving standard symptom-based treatment with another group receiving standard treatment plus Ecologic Barrier.\n\nParticipants will:\n\n* Receive IBS treatment for 2 months, with Ecologic Barrier added during either the first month or the second month, depending on random assignment.\n* Attend a follow-up visit after 1 month of treatment.\n* Take part in interviews about IBS severity, symptom improvement, adverse events, and symptoms of depression and anxiety at baseline, 2 weeks, 4 weeks, 8 weeks, and 12 weeks.",[76],"Irritable Bowel Syndrome With Diarrhea",[78,79,80,81,82,83,84,85],"Irritable bowel syndrome","IBS-D","Probiotics","DASS-21","Upper gastrointestinal symptoms","Stress","Depression","Anxiety","2026-06-15",{"date":88,"type":89},"2026-06-18","ACTUAL",{"date":91,"type":89},"2024-06-01",{"date":93,"type":70},"2026-06-30",{"name":5,"class":6},1]