[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630465":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":39,"centralContacts":43,"locations":50,"responsibleParty":68,"collaborators":55,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":55,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":55,"enrollmentInfo":81,"targetDuration":55,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":52,"whyStopped":55,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Universidade Federal de Pernambuco","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS + Cervical tsMS","EXPERIMENTAL","Participants will receive a combined neuromodulation protocol consisting of repetitive transcranial magnetic stimulation (rTMS) applied over the primary motor cortex, followed by trans-spinal magnetic stimulation (tsMS) at the cervical level.",[13,14],"Device: Repetitive Transcranial Magnetic Stimulation","Device: Cervical Trans-spinal Magnetic Stimulation",{"label":16,"type":10,"description":17,"interventionNames":18},"rTMS + Thoracic tsMS","Participants will receive a combined neuromodulation protocol consisting of repetitive transcranial magnetic stimulation (rTMS) applied over the primary motor cortex, followed by trans-spinal magnetic stimulation (tsMS) at the thoracic level.",[13,19],"Device: Thoracic Trans-spinal Magnetic Stimulation",[21,28,34],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation","Repetitive transcranial magnetic stimulation applied over the primary motor cortex using standardized stimulation parameters.",[9,16],[27],"rTMS",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Cervical Trans-spinal Magnetic Stimulation","Trans-spinal magnetic stimulation applied at the cervical level using standardized stimulation parameters.",[9],[33],"tsMS",{"type":22,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Thoracic Trans-spinal Magnetic Stimulation","Trans-spinal magnetic stimulation applied at the thoracic level using standardized stimulation parameters.",[16],[33],[40],{"name":41,"affiliation":5,"role":42},"Kátia Monte-Silva, PhD in Neurosciences","STUDY_DIRECTOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":48,"email":49},"Ana Cecília Ribeiro Nascimento, Msc. student","CONTACT","(81) 99893-6664","+55","anaceciliaribeiro.n@gmail.com",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Recife","Pernambuco",null,"Brazil","BR",{"type":59,"coordinates":60},"Point",[61,62],-34.88111,-8.05389,{"lat":62,"lon":61},[65],{"name":66,"role":46,"phone":67,"phoneExt":55,"email":49},"Ana Cecília Ribeiro","+55 8199893-6664",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":55,"oldOrganization":55},"PRINCIPAL_INVESTIGATOR","Kátia Monte-Silva","Professor","100630465","effects-of-the-stimulation-site-of-tsms-with-tms-on-functional-mobility-in-individuals-with-parkinsons-disease-100630465",false,"NCT07488026","Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease","Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease","Inclusion Criteria: (i) a clinical diagnosis of Parkinson's disease confirmed by a neurologist; (ii) stable dopaminergic pharmacological treatment for at least three months; (iii) age 40 years or older; (iv) disease stage between 2.5 and 3 on the modified Hoehn and Yahr scale; (v) (v) gait impairment, defined as the occurrence of at least one freezing of gait episode per week.\n\n\\-\n\nExclusion Criteria:\n\n(i) other neurological disorders, orthostatic hypotension, vestibular, musculoskeletal, or visual impairments that could compromise performance on the proposed assessments; (ii) other osteomuscular conditions affecting the lower limbs that interfere with mobility and functional performance; (iii) a Montreal Cognitive Assessment (MoCA) score lower than 21 points; (iv) prior surgical procedures for Parkinson's disease; or (v) contraindications to magnetic stimulation techniques, including a history of seizures or the presence of metallic implants in the neck or spinal region.","ALL","40 Years",{"count":82,"type":83},30,"ESTIMATED","INTERVENTIONAL",[86],"NA","This randomized clinical trial aims to compare the effects of two different trans-spinal magnetic stimulation (tsMS) application sites, cervical versus thoracic, when combined with repetitive transcranial magnetic stimulation (rTMS), on functional mobility in individuals with Parkinson's disease (PD). Participants diagnosed with PD will be randomized into two intervention groups (rTMS + cervical tsMS or rTMS + thoracic tsMS) and will undergo 10 treatment sessions. Outcomes will include functional mobility, gait speed, motor function, freeing of gait, balance, quality of life, global perceived improvement and adverse events. The study is expected to identify the most effective tsMS application site to enhance mobility and motor outcomes in PD, contributing to the optimization and standardization of tsMS protocols as an adjunct therapy.",[89,90,91,92],"Parkinson's Disease (PD)","Gait Disorders","Transcranial Magnetic Stimulation","Spinal Cord Stimulation",[94,95,96,97],"gait disorders","spinal cord stimulation","transcranial magnetic stimulation","parkinson's disease","2026-03-18",{"date":100,"type":101},"2026-03-23","ACTUAL",{"date":103,"type":101},"2026-01-05",{"date":105,"type":83},"2026-12",{"name":5,"class":6},1]