[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513380":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Istituto Auxologico Italiano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Population # 1",null,"De novo patients with acromegaly, diagnosed according to Endocrine Society guidelines, aged equal or above 18 years old",[13],"Procedure: Medical surgery therapy",{"label":15,"type":10,"description":16,"interventionNames":10},"Population # 2","Acromegalic patients with different disease status (active disease despite ongoing therapies, controlled disease under medical therapy, and disease remission), aged equal or above 18 years old",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Medical surgery therapy","De novo patients with acromegaly will undergo medical\u002Fsurgical therapy of this disease, according to the guidelines of the Endocrine Society. In this population (group #1) morpho-functional examinations together with the evaluation of the stage of the disease, with serum dosage of GH and IGF-1, will be performed at baseline and at months 3, 6 and 12 after initiating the treatment.",[9],[24],{"name":25,"affiliation":26,"role":27},"Giovanni Vitale","Istituto Auxologico Italiano IRCCS","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Sara Farina, Doctor","CONTACT","+393386822298","sara.farina@unimi.it",[35],{"facility":36,"status":37,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Istituto Auxologico Italiano IRCCS San Luca","RECRUITING","Milan","20149","Italy","IT",{"type":43,"coordinates":44},"Point",[45,46],12.59836,42.78235,{"lat":46,"lon":45},[49],{"name":25,"role":31,"phone":10,"phoneExt":10,"email":50},"g.vitale@auxologico.it",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":6},"Politecnico di Milano","100513380","effects-of-therapies-in-the-acromegaly-disease-acral-morpho-functional-study-100513380",false,"NCT05964712","Effects of Therapies in the Acromegaly Disease: Acral Morpho-functional Study","ACROMORFO","Inclusion Criteria:\n\n* De novo patients with acromegaly (group # 1), diagnosed according to Endocrine Society guidelines,\n* Age equal to18 years or older\n* Acromegalic patients with different disease status (group #2)\n* Age equal to18 years or older\n\nExclusion Criteria:\n\n* Cardiorespiratory, neurological or musculoskeletal disorder\n* Previous orthopaedic surgery\n* Previous lower limbs traumatic injuries","ALL","18 Years","90 Years",{"count":67,"type":68},30,"ESTIMATED","OBSERVATIONAL","Acromegaly is a rare chronic disease due to excessive secretion of growth hormone (GH) and insulin-like growth factor-I (IGF-I), caused in over 98% of cases by GH-secreting pituitary adenoma. Prolonged exposure to GH\u002FIGF-I excess is the cause of increased mortality and morbidity in these patients. Arthropathy occurs in about 75% of acromegalic patients. Any joint may be affected, with the development of osteoarthritis, arthralgia, and an increase in fracture risk.\n\nThe aims of the present project are to evaluate the dimensions of hands and feet with the 3D scanner method and to perform a quantitative analysis of movement through Gait Analysis technique in de novo patients with acromegaly (group # 1) and in patients with different disease status (group #2).",[72],"Acromegaly","2025-08-01",{"date":75,"type":76},"2025-08-03","ACTUAL",{"date":78,"type":76},"2019-06-18",{"date":80,"type":68},"2025-12-31",{"name":5,"class":6},1]