[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644080":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":38,"centralContacts":39,"locations":45,"responsibleParty":63,"collaborators":38,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":38,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":93,"whyStopped":38,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Myofascial Release Group","EXPERIMENTAL","Participants in this group will receive standardized myofascial release targeting the thoracolumbar fascia. The intervention will consist of 18 sessions over 6 weeks (3 sessions per week), each lasting approximately 40 minutes. The technique involves sustained low-load manual pressure using a crossed-hands approach applied to bilateral L2-L3 and L4-L5 regions of the thoracolumbar fascia. Treatment will be delivered by a trained physiotherapist following a standardized protocol. No additional physiotherapy interventions will be provided during the study period",[13],"Behavioral: Myofascial Release of Thoracolumbar Fascia",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Myofascial Release Group","SHAM_COMPARATOR","Participants in this group will receive sham myofascial release targeting the same anatomical regions as the experimental group. Light manual contact (\\\u003C50 g force) will be applied without therapeutic pressure or fascial engagement. The session duration and frequency will be identical to the experimental group (18 sessions over 6 weeks, 3 sessions per week, approximately 40 minutes per session). Participants will receive identical positioning and therapist contact time to control for placebo and attention effects.",[19],"Other: Sham Myofascial Release",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Myofascial Release of Thoracolumbar Fascia","Standardized myofascial release targeting the thoracolumbar fascia will be administered over 18 sessions across 6 weeks (3 sessions per week). Each session will last approximately 40 minutes and will involve sustained low-load manual pressure using a crossed-hands technique applied bilaterally at L2-L3 and L4-L5 regions. The intervention aims to reduce fascial stiffness and improve tissue mobility. Treatment will be delivered by a trained physiotherapist following a standardized protocol. No additional physiotherapy interventions will be provided during the study period",[9],[27,28,29],"Crossed-hands Myofascial Release","Thoracolumbar Fascial Release","Manual Fascial Therapy",{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Sham Myofascial Release","Sham myofascial release will be applied over the same anatomical regions as the experimental group using light manual contact (\\\u003C50 g force) without therapeutic pressure or fascial engagement. Sessions will be matched in duration (approximately 40 minutes), frequency (3 sessions per week), and total duration (6 weeks, 18 sessions). The aim is to control for placebo effects, therapist attention, and patient expectation",[15],[35,36,37],"Placebo manual therapy","Light touch intervention","Sham fascial release",null,[40],{"name":41,"role":42,"phone":43,"phoneExt":38,"email":44},"Manahil Nisar, DPT","CONTACT","03240691766","dr.manahilnisar@gmail.com",[46],{"facility":47,"status":38,"city":48,"state":49,"zip":38,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Affiliated Teaching Hospitals of University of Health Sciences Lahore","Lahore","Punjab Province","Pakistan","PK",{"type":53,"coordinates":54},"Point",[55,56],74.35071,31.558,{"lat":56,"lon":55},[59,60,61],{"name":41,"role":42,"phone":38,"phoneExt":38,"email":44},{"name":38,"role":42,"phone":38,"phoneExt":38,"email":44},{"name":41,"role":62,"phone":38,"phoneExt":38,"email":38},"PRINCIPAL_INVESTIGATOR",{"type":62,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Manahil Nisar","Principal Investigator","100644080","effects-of-thoracolumbar-fascia-myofascial-release-in-chronic-low-back-pain-100644080",false,"NCT07667062","Effects of Thoracolumbar Fascia Myofascial Release in Chronic Low Back Pain","Effects of Myofascial Release Targeting the Thoracolumbar Fascia on Fascial Morphology, Functional Outcomes, and Pain Self-Efficacy in Adults With Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial","TLF-MFR-LBP","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Non-specific low back pain duration \\> 12 weeks\n* Average pain intensity NRS ≥ 3 over the past week\n* Able to provide written informed consent\n* Able to attend 18 supervised sessions over 6 weeks (3 sessions\u002Fweek)\n\nExclusion Criteria:\n\n* Specific spinal pathology (fracture, disc herniation with neurological deficit, spinal stenosis, inflammatory arthropathy, malignancy)\n* Previous lumbar surgery\n* Current pregnancy\n* Severe psychiatric disorder or active psychosis\n* Manual therapy or physiotherapy for LBP within the previous 3 months\n* Systemic connective tissue disorder (e.g., Ehlers-Danlos syndrome, Marfan syndrome)\n* Contraindication to ultrasound imaging or manual therapy.","ALL","18 Years","60 Years",{"count":78,"type":79},65,"ESTIMATED","INTERVENTIONAL",[82],"NA","The thoracolumbar fascia (TLF) is thickened and stiffer in individuals with chronic non-specific low back pain (CNSLBP) and may contribute to pain persistence. Myofascial release (MFR) has been shown to reduce TLF stiffness acutely; however, its longer-term effects on fascial morphology and pain self-efficacy remain unclear. This randomized controlled trial will investigate the effects of a standardized 6-week MFR program targeting the thoracolumbar fascia compared with sham MFR in adults with CNSLBP. A total of 65 participants aged 18-60 years with CNSLBP will be randomized in a 1:1 ratio to either standardized MFR or sham MFR. The intervention will consist of 18 treatment sessions delivered over 6 weeks. Primary outcomes include thoracolumbar fascia thickness measured by B-mode ultrasound, thoracolumbar fascia stiffness measured by shear-wave elastography, and pain self-efficacy measured using the Pain Self-Efficacy Questionnaire (PSEQ). Secondary outcomes include pain intensity, functional disability, lumbar flexion range of motion, and patient global impression of change. Outcomes will be assessed at baseline and after completion of the 6-week intervention period.",[85],"Chronic Non-specific Low Back Pain",[87,88,89,90,91,92],"Thoracolumbar fascia","Myofascial release","Chronic low back pain","Fascia thickness","Fascial stiffness","Pain self-efficacy","NOT_YET_RECRUITING","2026-06-23",{"date":96,"type":97},"2026-06-26","ACTUAL",{"date":99,"type":79},"2026-06-20",{"date":101,"type":79},"2026-08",{"name":5,"class":6},1]