[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612630":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":26,"responsibleParty":44,"collaborators":26,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":26,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":26,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":26},{"fullName":5,"class":6},"Bahçeşehir University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active taVNS Stimulation","EXPERIMENTAL","Active taVNS will be applied bilaterally to the cymba conchae and tragus regions using the VaguStim device. Stimulation will follow standard parameters used in cognitive studies to minimize cardiac side effects. Parameters: biphasic waveform, 25 Hz frequency, 250 μs pulse width, and intensity individually adjusted below the sensory threshold (0.5-4 mA). Each session will last 20 minutes.",[13],"Device: Active taVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Stimulation","SHAM_COMPARATOR","For the sham condition, electrodes will be placed on the earlobe bilaterally, an area not innervated by the vagus nerve, using the same device and parameter settings but without delivering active stimulation. This setup controls for placebo effects.",[19],"Device: Sham Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active taVNS","Active taVNS will be delivered bilaterally to the cymba conchae and tragus regions using the VaguStim device. Stimulation parameters follow cognitive-neuroscience standards to minimize cardiac side effects: biphasic waveform, 25 Hz frequency, 250 μs pulse width, and intensity individually adjusted below the sensory threshold (0.5-4 mA). Each stimulation session lasts 20 minutes.\n\nThis intervention corresponds to the Active taVNS Stimulation arm.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Sham stimulation will be delivered using the same VaguStim device, but electrodes will be placed bilaterally on the earlobe, an area not innervated by the vagus nerve. Device parameters will be set to match the active condition, but no true vagus nerve stimulation is delivered. This procedure controls for placebo and participant expectancy effects.\n\nThis intervention corresponds to the Sham Stimulation arm.",[15],[31],{"name":32,"affiliation":5,"role":33},"Ali Veysel Ozden","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Yara A Skout","CONTACT","+905316766782","yaraskout@gmail.com",{"name":41,"role":37,"phone":42,"phoneExt":26,"email":43},"Ali Vesel Ozden Assistant Professor","00905065994233","aliveysel.ozden@bau.edu.tr",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Yara Atef Skout","Principal investigator","100612630","effects-of-transcutaneous-auricular-vagus-nerve-stimulation-on-cognitive-performance-and-sex-differences-100612630",false,"NCT07256080","Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences","A Sham-Controlled Cross-Over Study Examining the Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognitive Performance and Gender Differences in Healthy Adults","Inclusion Criteria:\n\n* Healthy young adults aged 18-30 years\n* Ability to provide informed consent\n* Right-handed participants (to reduce variability in cognitive performance)\n* Normal or corrected-to-normal vision and hearing\n* Female participants tested during the follicular phase of the menstrual cycle (days 5-10) to minimize hormonal effects on cognition and vagal tone\n\nExclusion Criteria:\n\n* History of neurological or psychiatric disorders\n* Cardiovascular disease\n* Use of psychoactive medications\n* Substance dependence, including alcohol, illicit drugs, or nicotine\n* Pregnancy or breastfeeding\n* Skin conditions or ear anomalies that interfere with electrode placement\n* Metal implants in the head or neck region\n* History of epilepsy or migraine",true,"ALL","18 Years","30 Years",{"count":60,"type":61},60,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults. The study uses a sham-controlled, cross-over design in which each participant receives both active taVNS and sham stimulation in separate sessions. Each participant completes both conditions (active and sham) in a randomized order using a crossover design. Cognitive performance will be assessed before and after each session using standardized tests. The study also explores whether males and females respond differently to taVNS, in order to identify potential sex-related differences in cognitive outcomes.",[67,68,69,70,71,72,73,74],"Cognitive Assessment","Cognition","taVNS","Vagus Nerve Stimulation","Executive Functions","Healthy Participants","Neuromodulation","Sex Differences","NOT_YET_RECRUITING","2025-11-27",{"date":78,"type":79},"2025-12-01","ACTUAL",{"date":81,"type":61},"2025-12",{"date":83,"type":61},"2026-05",{"name":5,"class":6}]