[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543215":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":31,"responsibleParty":48,"collaborators":50,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Lund University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Women in labor",null,"Women admitted to labor wards for delivery",[13],"Other: TB infection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"TB infection","Outcomes will be compared with regard to result of interferon-gamma release assay test for TB infection",[9],[20],{"name":21,"affiliation":5,"role":22},"Per Bjorkman, MD, PhD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+46-40337711","per.bjorkman@med.lu.se",{"name":29,"role":25,"phone":10,"phoneExt":10,"email":30},"Selam Ghebrechristos, MD","selam3148@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Gandhi Memorial Hospital","RECRUITING","Addis Ababa","Ethiopia","ET",{"type":39,"coordinates":40},"Point",[41,42],38.74689,9.02497,{"lat":42,"lon":41},[45],{"name":46,"role":25,"phone":47,"phoneExt":10,"email":30},"Selam Gebrechristos, MD","0921911716438",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[51,53],{"name":52,"class":6},"Addis Ababa University",{"name":54,"class":6},"Armauer Hansen Research Institute, Ethiopia","100543215","effects-of-tuberculosis-infection-on-development-and-function-of-the-placenta-100543215",false,"NCT06352970","Effects of Tuberculosis Infection on Development and Function of the Placenta","Effects of Tuberculosis Infection on Placental Development and Function","Inclusion Criteria:\n\n* Women admitted for delivery to study sites\n* Written informed consent\n* Age 18 years or greater\n\nExclusion Criteria:\n\n* Chronic comorbidities (other than TB, HIV or pregnancy-related disorder)\n* Twin pregnancy","FEMALE","18 Years",{"count":65,"type":66},500,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta.\n\nThe main questions it aims to answer are:\n\n* Does TB infection affect the structure of the placenta?\n* Does TB infection affect the function of the placenta?\n\nPregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection:\n\n* Pathological lesions of the placenta\n* Gene and protein expression patterns linked to pregnancy-related disorders\n* Infant outcome at birth and at 6 weeks after birth",[70,71,72],"Pregnancy Related","Tuberculosis Infection","Placenta Diseases",[74,75,76],"placenta","tuberculosis","pregnancy complication","2025-03-14",{"date":79,"type":80},"2025-03-17","ACTUAL",{"date":82,"type":80},"2024-10-01",{"date":84,"type":66},"2027-12-31",{"name":5,"class":6},1]