[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530445":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":70,"collaborators":73,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":30,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic Exercise and Mediterranean Diet","ACTIVE_COMPARATOR","Subjects randomized and assigned to this intervention group will follow the low glycaemic index Mediterranean diet and simultaneously perform 180 minutes of moderate-intensity aerobic exercise per week for 4 months. Intervention type: aerobic exercise and Mediterranean diet.",[13],"Behavioral: Aerobic Exercise and diet intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"HITT and Mediterranean Diet","Subjects randomized and assigned to this intervention group will follow the low glycaemic index Mediterranean diet and simultaneously perform 150 minutes per week of high-intensity interval exercise (HITT) in the gym for 4 months. Intervention type: HIIT and Mediterranean diet.",[18],"Behavioral: Hiit and diet intervention",{"label":20,"type":10,"description":21,"interventionNames":22},"Mediterranean Diet","Subjects randomized and assigned to this intervention group will follow the low-glycaemic index Mediterranean diet for 4 months. Intervention type: Mediterranean Diet.",[23],"Behavioral: Diet",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Aerobic Exercise and diet intervention","subjects randomized and assigned to one intervention group, will follow the low glycaemic index Mediterranean diet and simultaneously perform moderate-intensity aerobic exercises",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Hiit and diet intervention","subjects randomised and assigned to one intervention group, will follow the low glycaemic index Mediterranean diet and simultaneously perform high-intensity interval exercises in the gym",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Diet","subjects randomised and assigned to this intervention group will follow the low-glycaemic index Mediterranean diet",[20],[40],{"name":41,"affiliation":42,"role":43},"Endrit Shahini, MD","IRCCS Saverio de Bellis","PRINCIPAL_INVESTIGATOR",[45,49],{"name":41,"role":46,"phone":47,"phoneExt":30,"email":48},"CONTACT","00390804994249","endrit.shahini@irccsdebellis.it",{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},"Antonella Bianco","00390804994653","antonella.bianco@irccsdebellis.it",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"IRCCS De Bellis","RECRUITING","Castellana Grotte","Bari","70013","Italy","IT",{"type":63,"coordinates":64},"Point",[65,66],17.16549,40.88643,{"lat":66,"lon":65},[69],{"name":41,"role":46,"phone":47,"phoneExt":30,"email":48},{"type":43,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Dr. Endrit Shahini","Dr",[74,76],{"name":50,"class":75},"UNKNOWN",{"name":77,"class":75},"Isabella Franco","100530445","effects-of-two-different-exercise-programs-and-diet-in-obese-subjects-with-nafld-100530445",false,"NCT06186869","Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD","Effects of Two Different Exercise Programs Combined With the Mediterranean Diet on Inflammatory Status in Subjects With Obesity and NAFLD","Obesity_AF","Inclusion Criteria:\n\n* BMI ≥ 30 kg\u002Fm2 or an abdominal circumference (waist) \\> 94 cm in men and \\> 80 cm in women (IDF criteria for the definition of abdominal obesity) with or without the characteristics that characterise metabolic syndrome\n* Age range 18-65 years, both sexes\n* Diagnosis of hepatic steatosis, formulated on the basis of recognised criteria (fibroscan (CAP (controlled attenuation parameter) \\> 238 dB\u002Fm)).\n\nExclusion Criteria:\n\n* Normal and underweight subjects\n* Presence of any pathology that may influence the presence of steatosis apart from pathologies that are inclusion criteria, neurological and psychiatric pathologies, gastrointestinal, oncological and cardiovascular diseases\n* Pregnancy or breastfeeding\n* Subjects with osteoarticular pathologies that may prevent regular exercise\n* Inability to quantify the degree of NAFLD by Fibroscan\n* Person not in possession of a medical certificate of fitness for non-competitive physical activity.",true,"ALL","18 Years","65 Years",{"count":91,"type":92},90,"ESTIMATED","INTERVENTIONAL",[95],"NA","The aim of the study is to estimate the effectiveness of two different exercise programs combined with the Mediterranean diet versus diet alone on inflammatory status in subjects aged 18-65 years with obesity (BMI\\>30) and Non-Alcoholic Fatty Liver Disease (NAFLD) (CAP \\>248 dB\u002Fm).",[98,99],"Obesity","NAFLD",[98,101,102,99],"Physical Exercise","systemic inflammation","2026-03-24",{"date":105,"type":106},"2026-03-27","ACTUAL",{"date":108,"type":106},"2023-10-02",{"date":110,"type":92},"2026-12-23",{"name":5,"class":6},1]