[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584045":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":87,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"1st Vibrating mesh nebulisation and 2nd jet nebulisation","EXPERIMENTAL","Participants will receive a single dose of salbutamol whilst on NIV via vibrating mesh nebulisation on their first visit. After a minimum 48-hour washout period, they will receive the same dose of salbutamol via jet nebulisation while on NIV.",[13,14],"Device: Vibrating mesh nebulisation","Device: Jet nebuliser",{"label":16,"type":10,"description":17,"interventionNames":18},"1st Jet nebulisation and 2nd vibrating mesh nebulisation","Participants will receive a single dose of salbutamol whilst on NIV via jet nebuliser on their first visit. After a minimum 48-hour washout period, they will receive the same dose of salbutamol via vibrating mesh nebuliser while on NIV.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Vibrating mesh nebulisation","Vibrating mesh nebulisation (VMN) uses a mesh membrane that oscillates at high frequency (typically 128kHz) to produce a stream of drug-carrying droplets of pre-determined size to be inhaled",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Jet nebuliser","Jet nebulisers use the flow of a gas (air or oxygen) to draw medication up through a capillary tube to generate small particles to be inhaled.",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Eui-Sik Suh, MBBS MChem(Oxon) PhD FRCP","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+44 207 188 7727","euisik.suh@gstt.nhs.uk",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Gillian Radcliffe","+442071888070","gillian.radcliffe@gstt.nhs.uk",[44],{"facility":45,"status":25,"city":46,"state":25,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Lane Fox Unit, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust","London","SE1 7EH","United Kingdom","UK",{"type":51,"coordinates":52},"Point",[53,54],-0.12574,51.50853,{"lat":54,"lon":53},[57,58,61],{"name":40,"role":36,"phone":25,"phoneExt":25,"email":42},{"name":59,"role":60,"phone":25,"phoneExt":25,"email":25},"Katrina Abernethy, MBBS Mres MRCP","SUB_INVESTIGATOR",{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":63,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100584045","effects-of-vibrating-mesh-nebulisation-in-patients-with-copd-during-non-invasive-ventilation-vmn-niv-100584045",false,"NCT06884228","Effects of Vibrating Mesh Nebulisation in Patients With COPD During Non-invasive Ventilation (VMN-NIV)","VMN-NIV","Inclusion Criteria:\n\n* Patients with COPD receiving home non-invasive ventilation for chronic respiratory failure under the Lane Fox Respiratory Service at Guy's and St Thomas' NHS Foundation Trust\n* Tolerating home non-invasive ventilation for at least 4 hours\u002F24 hours\n* Aged 18-80 years old\n* Able to communicate symptom burden to the research team\n* Able to give informed consent for participation in the study\n* Clinical stability, with no acute exacerbations of COPD for 2 weeks prior to enrolment\n\nExclusion Criteria:\n\n* Severe, non-respiratory organ dysfunction including, but not limited to:\n\n  * Congestive cardiac failure\n  * Significant cardiovascular disease\n  * End-stage malignancy\n  * End-stage renal failure\n* Acute pulmonary pathology requiring emergency treatment including, but not limited to:\n\n  * Pneumonia\n  * Pneumothorax\n  * Pulmonary embolism\n* Severe cognitive impairment\n* Psychosocial factors that would preclude completion of the study protocol","ALL","18 Years","80 Years",{"count":75,"type":76},12,"ESTIMATED","INTERVENTIONAL",[79],"NA","Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by forced oscillation technique), respiratory flow, heart rate and rhythm, spirometry and breathlessness symptoms in patients with chronic obstructive pulmonary disease who require non-invasive ventilation.",[82,83],"COPD (Chronic Obstructive Pulmonary Disease)","Non-invasive Ventilation",[85,86],"vibrating mesh nebuliser","jet nebuliser","NOT_YET_RECRUITING","2025-03-17",{"date":90,"type":91},"2025-03-19","ACTUAL",{"date":93,"type":76},"2025-03-21",{"date":95,"type":76},"2026-05-01",{"name":5,"class":6},1]