[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596351":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":71,"collaborators":74,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":20,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Albert Einstein Healthcare Network","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Home-based treatment","EXPERIMENTAL","Self-administered Active Virtual Reality treatment",[13],"Behavioral: Active Virtual Reality Treatment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Active Virtual Reality Treatment","The self-administered active VR treatment will consist of 8 twice-weekly sessions, each approximately 1 hour in duration, during which subjects will participate in a variety of Virtual Reality active games that require leg movements while receiving high-quality visual feedback of the missing lower leg.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Laurel Buxbaum","CONTACT","215-663-6321","Laurel.Buxbaum@jefferson.edu",[28,46,57],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Jefferson Moss Rehabilitation Research Institute","RECRUITING","Philadelphia","Pennsylvania","19027","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-75.16362,39.95238,{"lat":40,"lon":39},[43],{"name":44,"role":24,"phone":25,"phoneExt":20,"email":45},"Rand Williamson","Rand.Williamson@jefferson.edu",{"facility":47,"status":30,"city":31,"state":32,"zip":48,"country":34,"countryCode":35,"cosmosGeoPoint":49,"geoPoint":51,"contacts":52},"University of Pennsylvania","19122",{"type":37,"coordinates":50},[39,40],{"lat":40,"lon":39},[53],{"name":54,"role":24,"phone":55,"phoneExt":20,"email":56},"Elisabetta Ambron","215-573-4336","eambron@pennmedicine.upenn.edu",{"facility":58,"status":30,"city":59,"state":60,"zip":61,"country":34,"countryCode":35,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"University of Washington","Seattle","Washington","98195",{"type":37,"coordinates":63},[64,65],-122.33207,47.60621,{"lat":65,"lon":64},[68],{"name":69,"role":24,"phone":25,"phoneExt":20,"email":70},"Jing-Sheng Li","jsli@uw.edu",{"type":72,"investigatorFullName":23,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Principal Investigator",[75],{"name":47,"class":6},"100596351","efficacy-and-mechanisms-of-virtual-reality-treatment-of-phantom-leg-painhome-based-treatment-100596351",false,"NCT07044323","Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment","PLP Home-Based","Inclusion Criteria:\n\n* Age 18 -100\n* Capacity to provide Informed Consent\n* Unilateral above or below knee amputation more than 3 months prior to enrollment\n* Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1.\n* Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10.\n\nExclusion Criteria:\n\n* History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes)\n* History of significant or poorly controlled psychiatric disorders\n* Substantial depression or anxiety affecting their ability to perform tasks necessary for the study.\n* Current abuse of alcohol or drugs, prescription or otherwise\n* Nursing a child, pregnant, or intent to become pregnant during the study","ALL","18 Years","100 Years",{"count":87,"type":88},44,"ESTIMATED","INTERVENTIONAL",[91],"NA","After amputation of an arm or leg, up to 90% of subjects experience a \"phantom limb\", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).",[94,95],"Phantom Pain Following Amputation of Lower Limb","Amputation",[97,98,99,100],"pain","phantom limb","lower limb amputation","treatment","2025-08-07",{"date":103,"type":104},"2025-08-08","ACTUAL",{"date":106,"type":104},"2025-06-16",{"date":108,"type":88},"2026-05-31",{"name":5,"class":6},3]