[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595700":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":60,"collaborators":10,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Zhejiang Cancer Hospital","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Induction chemoimmunotherapy followed by carbon ion radiotherapy and consolidation immunotherapy",null,[12,13,14],"Radiation: Carbon ion radiotherapy","Drug: Chemotherapy","Drug: Immunotherapy",[16,21,26],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"RADIATION","Carbon ion radiotherapy","Patients will receive platinum-based doublet chemotherapy and immunotherapy, followed by carbon iron radiotherapy and immunotherapy. The concrete immune checkpoint inhibitor includes durvalumab, sugemalimab, atezolizumab, benmelstobart, pembrolizumab, camrelizumab, toripalimab, tislelizumab, sintilimab, nivolumab, serplulimab, or penpulimab.",[9],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DRUG","Chemotherapy","platinum-based doublet chemotherapy",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Immunotherapy","The concrete immune checkpoint inhibitor includes durvalumab, sugemalimab, atezolizumab, benmelstobart, pembrolizumab, camrelizumab, toripalimab, tislelizumab, sintilimab, nivolumab, serplulimab, or penpulimab.",[9],[31],{"name":32,"affiliation":5,"role":33},"Yongling JI, MD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","0086-571-88122088","drjyl@msn.com",{"name":40,"role":36,"phone":37,"phoneExt":10,"email":41},"Min Fang","541387924@qq.com",[43],{"facility":5,"status":10,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Hangzhou","Zhejiang","310022","China","CN",{"type":50,"coordinates":51},"Point",[52,53],120.16142,30.29365,{"lat":53,"lon":52},[56,58,59],{"name":57,"role":36,"phone":37,"phoneExt":10,"email":38},"Yongling Ji, MD",{"name":40,"role":36,"phone":37,"phoneExt":10,"email":41},{"name":57,"role":33,"phone":10,"phoneExt":10,"email":10},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Ji Yongling","PI","100595700","efficacy-and-safety-of-chemoimmunotherapy-and-carbon-ion-radiotherapy-in-unresectable-locally-advanced-non-small-cell-lung-cancer-100595700",false,"NCT07035860","Efficacy and Safety of Chemoimmunotherapy and Carbon Ion Radiotherapy in Unresectable Locally Advanced Non-small Cell Lung Cancer","Efficacy and Safety of Induction Chemoimmunotherapy Followed by Carbon Ion Radiotherapy and Consolidation Immunotherapy in Unresectable Locally Advanced Non-small Cell Lung Cancer","Inclusion Criteria:\n\n* Unresectable, locally advanced non-small cell lung cancer (according to the 8th edition of the AJCC staging system).\n* No prior anti-cancer treatment.\n* No significant internal medical conditions or major organ dysfunction.\n\nExclusion Criteria:\n\n* Histological evidence of small cell lung cancer or other primary malignancies\n* EGFR, ALK, or ROS-1 gene mutations.\n* Active or prior autoimmune\u002Finflammatory disorders.\n* Inability to comply with study protocol as judged by the investigator.","ALL","18 Years","75 Years",{"count":75,"type":76},34,"ESTIMATED","OBSERVATIONAL","This is the first prospective clinical study to evaluate the efficacy and safety of induction chemoimmunotherapy followed by carbon ion radiotherapy and consolidation immunotherapy in patients with unresectable locally advanced non-small cell lung cancer (NSCLC). Based on this prospective study, tumor tissue, blood, urine, and stool samples from participants will be collected and analyzed to identify predictive markers of treatment response.",[80],"Carbon Ion Radiotheray",[82,83,84],"non-small cell lung cancer","carbon ion radiotherapy","immunotherapy","NOT_YET_RECRUITING","2025-06-17",{"date":88,"type":89},"2025-06-25","ACTUAL",{"date":91,"type":76},"2025-06-16",{"date":93,"type":76},"2028-06-15",{"name":62,"class":6},1]