[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585928":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":40,"collaborators":7,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":7,"enrollmentInfo":51,"targetDuration":7,"studyType":54,"phases":7,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"University Hospital, Antwerp","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Rita Jacobs, Dr.","Antwerp Univesity Hospital","PRINCIPAL_INVESTIGATOR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+32 3 821 36 35","rita.jacobs2@uza.be",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Petra Vertongen","+32 3 8214404","studies.inzo@uza.be",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Antwerp University Hospital","RECRUITING","Edegem","Antwerp","2650","Belgium","BE",{"type":32,"coordinates":33},"Point",[34,35],4.44504,51.15662,{"lat":35,"lon":34},[38,39],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},{"type":41,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100585928","efficacy-and-safety-of-citrate-anticoagulation-in-crrt-for-patients-with-liver-failuredysfunction-the-caution-trial-a-retrospective-study-on-etiology-of-liver-failure-and-their-complications-100585928",false,"NCT06908746","Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure\u002FDysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications","Caution","Inclusion Criteria:\n\n* Critically ill patients diagnosed with AKI requiring CRRT. Caution Protocol V1.0 24-07-2024\n* Documented liver failure or significant liver dysfunction (e.g., elevated liver enzymes, bilirubin levels, or clinical diagnosis of liver failure) and clincal diagnosis of shock (NE of 0.25 μg\u002Fkg\u002Fmin and or association of second vasopressor).\n* Age ≥ 18 years.\n\nExclusion Criteria:\n\n* NA","ALL","18 Years",{"count":52,"type":53},100,"ESTIMATED","OBSERVATIONAL","Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure\u002Fdysfunction and severe shock.\n\nObjectives\n\n1. Primary Objective: To determine if the etiology of liver failure impacts the incidence of citrate-related complications in patients undergoing CRRT.\n2. Secondary Objectives: To compare the efficacy of citrate anticoagulation in terms of renal recovery, filter lifespan, and patient survival between those with liver failure\u002Fdysfunction and severe shock.",[57,58],"Liver Failure","AKI - Acute Kidney Injury",[60,61,62],"CRRT","liver failure","AKI","2025-04-02",{"date":65,"type":66},"2025-04-03","ACTUAL",{"date":68,"type":66},"2024-09-30",{"date":70,"type":53},"2025-12-31",{"name":5,"class":6},1]