[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572055":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":63,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"The First Affiliated Hospital of Shanxi Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"H1 coil","ACTIVE_COMPARATOR","First, the 'hot spot' for activation of the abductor pollicis brevis muscle was established and motor threshold (MT) determined. Then, the H1 coil was advanced 6 cm anterior to the scalp surface.The rMT was rechecked at least once a week. Treatment intensity was 80% of rMT.During 4 consecutive weeks (5 sessions\u002Fwk) patients were treated daily . Patients in the treatment group will receive the Deep TMS protocol (80% of rMT, 18 Hz, 2 seconds on and 20 seconds off over a 20-minute period; total of 1,980 stimuli per session), applied over the left dorsolateral prefrontal cortex.",[13],"Device: deep transcranial magnetic stimulation with H1coil",{"label":15,"type":16,"description":17,"interventionNames":18},"H7 coil","EXPERIMENTAL","First, the 'hot spot' for activation of the abductor pollicis brevis muscle was established and motor threshold (MT) determined. Then, the H7 coil was advanced 4 cm anterior to 'hot spot' and aligned symmetrically over the dmPFC. The rMT was rechecked at least once a week.The rMT was rechecked at least once a week. Treatment intensity was 80% of rMT.During 4 consecutive weeks (5 sessions\u002Fwk) patients were treated daily . Patients in the treatment group will receive the Deep TMS protocol (80% of rMT, 18 Hz, 2 seconds on and 20 seconds off over a 20-minute period; total of 1,980 stimuli per session), applied over themedial prefrontal cortex.",[19],"Device: deep transcranial magnetic stimulation with H7 coil",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","deep transcranial magnetic stimulation with H1coil","Participants will receive dTMS treatment with H1 coil",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"deep transcranial magnetic stimulation with H7 coil","Participants will receive dTMS treatment with H7 coil",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Zhifen Liu","CONTACT","+8613703586547","zhifenliu@sxmu.edu.cn",[38,55],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Deep Transcranial Magnetic Stimulation","RECRUITING","Taiyuan","Shanxi","030001","China","CN",{"type":47,"coordinates":48},"Point",[49,50],112.56028,37.86944,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":54,"phoneExt":26,"email":36},"86+13703586547",{"facility":39,"status":40,"city":41,"state":42,"zip":56,"country":44,"countryCode":45,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"030012",{"type":47,"coordinates":58},[49,50],{"lat":50,"lon":49},[61],{"name":62,"role":34,"phone":35,"phoneExt":26,"email":36},"zhifen ZF Liu",{"type":64,"investigatorFullName":33,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","professor","100572055","efficacy-and-safety-of-dtms-in-adolescent-major-depressive-disorder-100572055",false,"NCT06728280","Efficacy and Safety of DTMS in Adolescent Major Depressive Disorder","Efficacy and Safety of Deep Transcranial Magnetic Stimulation in Adolescent Major Depressive Disorder: a Prospective Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients of all genders, aged between 11 and 23 years old, and right-handedness.\n* In accordance with the diagnostic criteria for the major depressive disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).\n* The current major depressive episode (MDE) must be confirmed using the Mini International Neuropsychiatric Interview (M.I.N.I).\n* Beck Depression Inventory, Second Edition (BDI-II): total BDI-II score\\> 13 at screening.\n* Subjects who can understand and are willing to strictly follow the clinical trial protocol to complete this study and sign informed consent.\n\nExclusion Criteria:\n\n* A diagnosis of other psychiatric disorders in the DSM-5.\n* Clinically significant laboratory abnormality or medical condition, that in the opinion of the investigator would hinder the subject in completing the procedures required by the study.\n* History of significant neurologic disease, including subdural hematoma, brain tumor, unexpected seizure\u002Fepilepsy disorder, or history of significant head trauma.\n* Have obvious suicide risk, or have actual suicide behavior within 6 months before the screening.\n* History of treatment with electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcranial Direct Current Stimulation (tDCS), or transcranial Alternating Current Stimulation (tACS) treatments for any disorders.\n* There are contraindications to magnetic resonance imaging (MRI) scanning or TMS treatment, such as metal or electronic instruments.\n* Participation in any investigational drug trial within 6 months before the baseline visit.\n* Other conditions that are not suitable for the study object in the researcher's judgment.","ALL","11 Years","23 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this randomized controlled trial is to explore the efficacy and safety of two different dTMS devices in adolescent depression: deep TMS H1 coil and deep TMS H7 coil.\n\nThe main questions it aims to answer are:\n\nType of study: Clinical trial. Participant population: Adolescents with major depressive disorder (MDD). Objective: To explore whether the H7 coil is no less effective than the H1 coil for adolescents with MDD, further providing clinicians with additional treatment options for patients.",[84],"Major Depressive Diorder",[86,84,87],"deep transcranial magnetic stimulation","adolescents","2025-03-10",{"date":90,"type":91},"2025-03-12","ACTUAL",{"date":93,"type":91},"2024-12-31",{"date":95,"type":78},"2026-06-30",{"name":33,"class":6},2]