[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637488":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":23,"locations":23,"responsibleParty":24,"collaborators":23,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":32,"eligibilityCriteria":33,"healthyVolunteers":28,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":23,"studyType":40,"phases":41,"briefSummary":43,"conditions":44,"keywords":52,"overallStatus":62,"whyStopped":23,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":23},{"fullName":5,"class":6},"Nakhia Impex LLC","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HA35 Topical Gel Intervention Group","EXPERIMENTAL","Participants receive a single topical application of 10% high-concentration 35 kDa HA35 gel to the pruritic skin area. Efficacy on ultra-rapid pruritus relief, duration of effect, and safety will be evaluated.",[13],"Device: 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Anti-Pruritic Gel",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Anti-Pruritic Gel","Topical skin gel containing 10% high-concentration 35 kDa hyaluronan fragment. Applied topically to pruritic areas to provide ultra-rapid relief of skin itching and improve associated inflammatory signs.",[9],[21,22],"HA35 Itch Relief Gel","Rapid Itch Relief HA35 Gel",null,{"type":25,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100637488","efficacy-and-safety-of-ha35-gel-for-ultra-rapid-skin-pruritus-relief-100637488",false,"NCT07580911","Efficacy and Safety of HA35 Gel for Ultra-Rapid Skin Pruritus Relief","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Topical 10% 35 kDa Hyaluronan (HA35) Gel for Ultra-Rapid Relief of Diverse Etiology Skin Pruritus","HA35-ITCH","Inclusion Criteria:\n\n* Age 18-65 years, male or female\n* Moderate-to-severe skin pruritus (NRS ≥6) due to eczema, neurodermatitis, insect bites, urticaria, or postoperative wound itch\n* Able to understand and complete NRS assessments independently\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Topical corticosteroid\u002Fantihistamine use within 2 weeks\n* Infected, broken, or exudative skin lesions at the application site\n* Known hypersensitivity to hyaluronan or gel components\n* Severe systemic disease or immune dysfunction\n* Pregnant or lactating women","ALL","18 Years","65 Years",{"count":38,"type":39},30,"ESTIMATED","INTERVENTIONAL",[42],"NA","This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel for ultra-rapid relief of moderate-to-severe skin pruritus from diverse etiologies (eczema, neurodermatitis, insect bites, urticaria, postoperative wound itch). Eligible participants will receive a single topical application of HA35 gel. The primary objective is to assess pruritus relief at 10 seconds, 45 minutes, 8 hours, 12 hours, and 24 hours post-application. Safety and local skin tolerability will be evaluated throughout the observation period. This is a minimal-risk, non-pharmacological, non-invasive intervention.",[45,46,47,48,49,50,51],"Skin Pruritus","Itch","Eczema Itch","Neurodermatitis","Insect Bite Itch","Urticaria","Postoperative Wound Pruritus",[53,54,55,56,45,57,58,59,60,61],"Hyaluronan","35 kDa Hyaluronan","HA35","Topical Gel","Itch Relief","Ultra-Rapid Relief","Anti-Pruritus","Non-Steroidal","Pilot Clinical Study","NOT_YET_RECRUITING","2026-05-05",{"date":65,"type":66},"2026-05-12","ACTUAL",{"date":68,"type":39},"2026-06-20",{"date":70,"type":39},"2026-08-20",{"name":5,"class":6}]