[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100433164":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":37,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Petrovsky National Research Centre of Surgery","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"cardiac surgery patients with multiple organ dysfunction","EXPERIMENTAL","hemoperfusion procedure with polymyxin B will be performed for 12 hours",[13],"Device: hemoperfusion with polymyxin B",{"label":15,"type":16,"description":17,"interventionNames":18},"cardiac surgery patients","NO_INTERVENTION","without hemoperfusion with polymyxin B",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","hemoperfusion with polymyxin B","polymyxin B is covalently immobilized on polystyrene strands, selectively removes endotoxin and at the same time there is no leaching of the ligand, immobilization is carried out by electrostatic interaction and Vanderwals force",[9],[26],"PMX 20 R",[28],{"name":29,"affiliation":30,"role":31},"MAXIM BABAEV, D.Sc.(medical)","Petrovsky NRCS","PRINCIPAL_INVESTIGATOR",[33],{"name":29,"role":34,"phone":35,"phoneExt":18,"email":36},"CONTACT","89160269066","maxbabaev@mail.ru",[38],{"facility":39,"status":40,"city":41,"state":18,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Petrovsky National Reasearch Centre of Surgery","RECRUITING","Moscow","119991","Russia","RU",{"type":46,"coordinates":47},"Point",[48,49],37.61781,55.75204,{"lat":49,"lon":48},[52],{"name":29,"role":34,"phone":35,"phoneExt":18,"email":36},{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100433164","efficacy-and-safety-of-hemoperfusion-with-polymyxin-b-in-septic-shock-associated-with-severe-endotoxemia-in-cardiac-surgery-patients--vs-ss-100433164",false,"NCT04920565","Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)","Evalution of the Efficacy and Safety of Hemoperfusion Use With Polymyxin B un Patients With Severe Endotoxemia With Multiple Organ Dysfunction Syndrome After Complicated Operations With Cardiopulmonary Bypass","РМХ vs SS","Inclusion Criteria:\n\n* SOFA +2 points in comparison with the previous assessment; РСТ more than 2 ng \u002F ml; CRP more than 150 ng \u002F ml; norepinephrine infusion; intestinal paresis; positive data of blood culture; ЕАА more than 0,6\n\nExclusion Criteria:\n\n* bleeding; heparin-induced thrombocytopenia","ALL","18 Years","80 Years",{"count":67,"type":68},20,"ESTIMATED","INTERVENTIONAL",[71],"NA","Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinical and laboratory manifestations. Violation of autoregulation and multiple organ dysfunctions in case of not timely started and \u002F or ineffective therapy lead to the development of multiple organ failure and thanatogenesis in 40-90% of cases. At the moment, there is no standardized approach to the treatment of the entire pool of sepsis patients. Pharmacological effects on receptors for interleukins and endotoxin, antibiotic therapy and immunoprotection do not allow taking the process under complete control. The pathogenesis and clinical diversity of manifestations dictates the need for a personalized approach based on identifying a group of patients with homogeneous characteristics and the course of the process, where one or another technique would have the greatest benefit. The choice of tactics for extracorporeal therapy should be based on early support of organ function and consistent elimination of high concentrations of trigger compounds (endotoxin, other metabolic products of microorganisms and products of cytolysis of a macroorganism), as well as aimed at minimizing the loss of proteins and immune complexes.\n\nThe aim of this clinical study was to assess the efficacy and safety of the selective adsorption of endotoxin in patients with severe multiple organ dysfunction after complicated cardiac surgery.",[74],"Multiple Organ Dysfunction With Severe Endotoxemia",[76,77,78,79],"test EAA","endotoxemia","hemoperfusion with Polymyxin B","cardiac syrgery","2024-11-20",{"date":82,"type":83},"2024-11-25","ACTUAL",{"date":85,"type":83},"2021-11-01",{"date":87,"type":68},"2025-12",{"name":5,"class":6},1]