[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547628":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":77,"locations":86,"responsibleParty":105,"collaborators":32,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":32,"eligibilityCriteria":113,"healthyVolunteers":109,"sex":114,"minAge":115,"maxAge":32,"enrollmentInfo":116,"targetDuration":32,"studyType":119,"phases":120,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":89,"whyStopped":32,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"General Hospital of Shenyang Military Region","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Glucocorticoids+routine treatment group","EXPERIMENTAL","Dexamethasone retention enema",[13,14],"Drug: Dexamethasone","Drug: Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation",{"label":16,"type":17,"description":18,"interventionNames":19},"Routine treatment group","ACTIVE_COMPARATOR","Routine treatment of acute radiation-induced intestinal injury according to the current practice guideline",[14],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexamethasone","Retention enema with 10mg dexamethasone, once a day, the total course of treatment for 1 week.",[9],[27],"RHP",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation","Treatment according to guideline of radiation-induced intestinal injury.",[9,16],null,[34,38,41,44,47,50,53,56,59,62,65,68,71,74],{"name":35,"affiliation":36,"role":37},"Xingshun Qi","The General Hospital of Northern Theater Command","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Xiaofeng Liu","The 960th Hospital of the Chinese People's Liberation Army",{"name":42,"affiliation":43,"role":37},"Xiaohua Bao","The 964th Hospital of the Chinese People's Liberation Army",{"name":45,"affiliation":46,"role":37},"Cheng Bai","The 967th Hospital of the Chinese People's Liberation Army",{"name":48,"affiliation":49,"role":37},"Junchen Ge","The 962rd Hospital of the Chinese People's Liberation Army",{"name":51,"affiliation":52,"role":37},"Dongshuai Su","The 963rd Hospital of the Chinese People's Liberation Army",{"name":54,"affiliation":55,"role":37},"Wenda Xu","The 81th Group Military Hospital of of the Chinese People's Liberation Army",{"name":57,"affiliation":58,"role":37},"Ran Jiang","The 966th Hospital of the Chinese People's Liberation Army",{"name":60,"affiliation":61,"role":37},"Yumei Hou","92493 Hospital of the Chinese People's Liberation Army",{"name":63,"affiliation":64,"role":37},"Hong Dai","Liaoning Provincial Corps Hospital of the Chinese People's Armed Police",{"name":66,"affiliation":67,"role":37},"Bingguo Piao","The 78th Group Military Hospital of the Chinese People's Liberation Army",{"name":69,"affiliation":70,"role":37},"Yufeng Zhang","The 79th Group Military Hospital of of the Chinese People's Liberation Army",{"name":72,"affiliation":73,"role":37},"Lichun Shao","Air Force Hospital of Northern Theater Command",{"name":75,"affiliation":76,"role":37},"Haijun Liang","96605 Hospital of the Chinese People's Liberation Army",[78,82],{"name":35,"role":79,"phone":80,"phoneExt":32,"email":81},"CONTACT","18909881019","xingshunqi@126.com",{"name":83,"role":79,"phone":84,"phoneExt":32,"email":85},"Qianqian Li","13940307473","1208594776@qq.com",[87],{"facility":88,"status":89,"city":90,"state":91,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":100,"contacts":101},"Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area)","RECRUITING","Shenyang","Liaoning","110840","China","CN",{"type":96,"coordinates":97},"Point",[98,99],123.43278,41.79222,{"lat":99,"lon":98},[102],{"name":103,"role":79,"phone":104,"phoneExt":32,"email":81},"Xingshun Qi, MD","86-18909881019",{"type":37,"investigatorFullName":35,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Director of Department of Gastroenterology","100547628","efficacy-and-safety-of-local-glucocorticoids-for-the-treatment-of-acute-radiation-induced-intestinal-injury-100547628",false,"NCT06410443","Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury","Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Grade II-III acute radiation-induced rectosigmoid injury\n2. Signed informed consents\n3. Age ≥18 years\n4. Rstimated survival time \\>1 year\n\nExclusion Criteria:\n\n1. Absolute contraindications to glucocorticoids\n2. A history of glucocorticoids treatment within 3 months\n3. Inflammatory bowel disease or infectious intestinal disease\n4. Recurrence of malignant tumor\n5. Colorectal cancer or metastasis\n6. Severe heart or lung diseases\n7. Recent history of surgery or trauma\n8. Poorly controlled hyperglycemia and hypertension\n9. Active tuberculosis\n10. Ssevere gastrointestinal ulcers\n11. Glaucoma\n12. Sychiatric diseases\n13. Pregnant or lactating","ALL","18 Years",{"count":117,"type":118},60,"ESTIMATED","INTERVENTIONAL",[121],"NA","Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with acute radiation-induced intestinal injury. However, the conclusions of related studies were controversial.",[124],"Radiation-Induced Intestinal Injury",[124,126],"glucocorticoid","2025-12-17",{"date":129,"type":130},"2025-12-24","ACTUAL",{"date":132,"type":130},"2024-08-01",{"date":134,"type":118},"2026-12-31",{"name":5,"class":6},1]