[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637469":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":23,"locations":23,"responsibleParty":24,"collaborators":23,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":31,"acronym":32,"eligibilityCriteria":33,"healthyVolunteers":28,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":23,"studyType":40,"phases":41,"briefSummary":43,"conditions":44,"keywords":50,"overallStatus":61,"whyStopped":23,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":23},{"fullName":5,"class":6},"Nakhia Impex LLC","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HA35 Overnight Occlusive Topical Gel Group","EXPERIMENTAL","Participants receive 10% high-concentration 35 kDa HA35 gel as overnight occlusive topical application to the entire face, once every 2 days for 5 applications over 10 days. Efficacy on facial fat, erythema, radiance, pores, and safety will be evaluated.",[13],"Device: 10% High-Concentration 35 kDa Hyaluronan (HA35) Facial Occlusive Gel",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","10% High-Concentration 35 kDa Hyaluronan (HA35) Facial Occlusive Gel","A topical, non-pharmacological facial gel containing 10% high-concentration 35 kDa hyaluronan fragment. Applied under occlusive conditions overnight to improve facial subcutaneous fat appearance, reduce erythema, enhance radiance, and improve pore condition.",[9],[21,22],"HA35 Facial Aesthetic Gel","Overnight HA35 Gel",null,{"type":25,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100637469","efficacy-and-safety-of-overnight-occlusive-ha35-gel-for-facial-aesthetic-improvement-100637469",false,"NCT07584811","Efficacy and Safety of Overnight Occlusive HA35 Gel for Facial Aesthetic Improvement","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Overnight Occlusive Topical 10% 35 kDa Hyaluronan (HA35) Gel for Facial Subcutaneous Fat Appearance, Erythema, Skin Radiance, and Pore Condition","HA35-FACIAL","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Seeking non-invasive improvement of facial appearance\n* Presenting with at least one of: facial subcutaneous fat accumulation, facial erythema, skin dullness, nasal alar pore enlargement\n* Baseline NRS score ≥2 for at least one target parameter\n* Ability to complete self-assessments\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Facial aesthetic treatments (injection, laser, fat reduction, peeling) within 2 weeks\n* Active facial dermatitis, infection, or open wounds\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women\n* Severe systemic disease or uncontrolled medical condition","ALL","18 Years","60 Years",{"count":38,"type":39},30,"ESTIMATED","INTERVENTIONAL",[42],"NA","This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of overnight occlusive topical application of 10% high-concentration 35 kDa hyaluronan (HA35) gel for facial aesthetic improvement. Eligible participants will receive overnight occlusive application once every 2 days for a total of 5 treatments over 10 days. The primary objectives are to assess changes in facial subcutaneous fat appearance, inflammatory erythema, skin radiance, and nasal alar pore enlargement after 1 and 5 applications. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive aesthetic intervention.",[45,46,47,48,49],"Facial Subcutaneous Fat","Facial Erythema","Skin Dullness","Nasal Alar Pore Enlargement","Facial Aesthetic Improvement",[51,52,53,54,55,56,46,57,58,59,60],"Hyaluronan","35 kDa Hyaluronan","HA35","Overnight Occlusive","Topical Gel","Facial Fat","Skin Radiance","Pore Improvement","Non-invasive Aesthetic","Pilot Clinical Study","NOT_YET_RECRUITING","2026-05-07",{"date":64,"type":65},"2026-05-13","ACTUAL",{"date":67,"type":39},"2026-05-01",{"date":69,"type":39},"2026-07-20",{"name":5,"class":6}]