[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596210":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":56,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Plasma adsorption+Endovascular Thrombectomy","EXPERIMENTAL","Patients are received plasma adsorption and endovascular thrombectomy.Plasma adsorption was initiated after endovascular thrombectomy once daily for 3 days.",[13,14],"Procedure: Plasma adsorption","Procedure: Endovascular Thrombectomy",{"label":16,"type":17,"description":18,"interventionNames":19},"Endovascular Thrombectomy","ACTIVE_COMPARATOR","The patients will be treated with endovascular thrombectomy .",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Plasma adsorption","Plasma adsorption was initiated after endovascular thrombectomy once daily for 3 days.",[9],null,{"type":22,"name":16,"description":28,"armGroupLabels":29,"otherNames":26},"The patients will be treated with endovascular thrombectomy.",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Zhenni Guo, MD,PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Yi Yang","CONTACT","0086-13756661217","doctor_yangyi@163.com",[41],{"facility":5,"status":26,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Changchun","Jilin","130000","China","CN",{"type":48,"coordinates":49},"Point",[50,51],125.32278,43.88,{"lat":51,"lon":50},[54],{"name":55,"role":37,"phone":38,"phoneExt":26,"email":39},"Yi Yang, MD,PhD",{"type":57,"investigatorFullName":36,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Associated Dean of First Hospital of Jilin University","100596210","efficacy-and-safety-of-plasma-adsorption-combined-with-evt-for-ais-lvo-100596210",false,"NCT07042490","Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO","Efficacy and Safety of Plasma Adsorption Combined With Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion of Anterior Circulation: A Multicenter, Randomized, Parallel-controlled Clinical Trial","PROMOTE-EVT","Inclusion Criteria:\n\n1. Age 18-80 years, male or female.\n2. Diagnosis of acute ischemic stroke within 12 hours of symptom onset, underwent endovascular thrombectomy (EVT) adhering to current guidelines for large vessel occlusion in the anterior circulation (confirmed by DSA as ICA,MCA-M1,MCA-M2,ACA-A1,ACA-A2 occlusion or tandem lesion) and achieve successful recanalization (mTICI grade 2b\u002F3).\n3. Baseline NIHSS after EVT ≥ 6 and ≤25 points.\n4. Randomization and the first plasma adsorption can be initiated within 12 hours after EVT.\n5. Pre-stroke mRS≤ 2 points.\n6. Patient\u002Flegally family members have signed the Informed consent form.\n\nExclusion Criteria:\n\n1. Imaging after EVT indicated malignant brain edema with midline shift or brain herniation and surgical treatment was planned.\n2. Parenchymal hemorrhage type 1, or type 2 confirmed by CT.\n3. Allergic to any ingredient of the plasma separator, the adsorption device, or the piping.\n4. Contraindications to plasma adsorption, platelet count \\\u003C60×10\\^9\u002FL,white blood cell\\\u003C4×10\\^9\u002FL, uncontrolled hypertension with persistent systolic blood pressure ≥200 mmHg or diastolic blood pressure ≥110 mmHg, uncontrolled hypotension, systolic blood pressure \\\u003C90 mmHg or diastolic blood pressure \\\u003C60 mmHg.\n5. Previous history of malignant tumors, autoimmune diseases or being treated with immunosuppressants, hormones, or tumor necrosis factor inhibitors.\n6. Previous history of organic heart disease and NYHA Class III or IV.\n7. Currently taking anticoagulant(dabigatran, rivaroxiban, warfarin, etc.), previous history of serious hematological system disorders, or abnormal coagulation function (international normalized ratio \\[INR\\], activated partial thromboplastin time \\[APTT\\], prothrombin time \\[PT\\] upper limit of the normal range).\n8. Severe liver and kidney dysfunction or abnormal laboratory test results（serum aspartate aminotransferase or alanine aminotransferase \\>3 times the upper limit of normal, serum creatinine\\>265umol\u002Fl(\\>3mg\u002Fdl)）.\n9. Pregnancy , lactation or life expectancy of less than 3 months or inability to complete the study for other reasons.\n10. Unwilling to be followed up or poor compliance.\n11. Current or past participation in other clinical research, or participation in this study within 3 months prior to admission.\n12. Other conditions that the researchers think make the patient unsuitable for the study.","ALL","18 Years","80 Years",{"count":71,"type":72},100,"ESTIMATED","INTERVENTIONAL",[75],"NA","The purpose of this study is to determine the efficacy and safety of plasma adsorption for patients of acute ischemic stroke who underwent endovascular thrombectomy due to large vessel occlusion of anterior circulation.",[78,16],"Acute Ischemic Stroke From Large Vessel Occlusion",[80,23,16],"Acute ischemic stroke","NOT_YET_RECRUITING","2025-06-27",{"date":84,"type":85},"2025-06-29","ACTUAL",{"date":87,"type":72},"2025-06-30",{"date":89,"type":72},"2027-06-30",{"name":36,"class":6},1]