[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636559":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":43,"locations":52,"responsibleParty":79,"collaborators":81,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":38,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":38,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":110,"whyStopped":38,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Servicio Canario de Salud","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS applied 10 minutes after emotional re-experiencing through expressive writing (SG1)","EXPERIMENTAL","Both experimental groups will receive the same excitatory repetitive transcranial magnetic stimulation (rTMS) protocol targeting the right dorsolateral prefrontal cortex (rDLPFC).\n\nThe stimulation protocol will consist of:\n\n* Frequency: 10 Hz\n* Intensity: 80% of resting motor threshold\n* Train duration: 4 seconds\n* Inter-train interval: 11 seconds\n* 50 trains per session\n* Approximately 12 minutes per session\n* Total of 2,000 pulses per session\n\nTreatment will be administered five days per week over three weeks, for a total of 15 sessions and 30,000 pulses.\n\nEmotional re-experiencing will be induced through expressive writing. Participants will write for 15 minutes once per week about the thoughts and emotions associated with their traumatic or highly stressful experiences throughout the treatment period. In this group, expressive writing will take place 10 minutes before the rTMS session.",[13,14],"Device: Repetitive Transcranial Magnetic Stimulation","Behavioral: Expressive writing",{"label":16,"type":10,"description":17,"interventionNames":18},"rTMS applied 10 minutes before emotional re-experiencing through expressive writing (SG2)","Both experimental groups will receive the same excitatory repetitive transcranial magnetic stimulation (rTMS) protocol targeting the right dorsolateral prefrontal cortex (rDLPFC).\n\nThe stimulation protocol will consist of:\n\n* Frequency: 10 Hz\n* Intensity: 80% of resting motor threshold\n* Train duration: 4 seconds\n* Inter-train interval: 11 seconds\n* 50 trains per session\n* Approximately 12 minutes per session\n* Total of 2,000 pulses per session\n\nTreatment will be administered five days per week over three weeks, for a total of 15 sessions and 30,000 pulses.\n\nEmotional re-experiencing will be induced through expressive writing. Participants will write for 15 minutes once per week about the thoughts and emotions associated with their traumatic or highly stressful experiences throughout the treatment period. In this group, expressive writing will take place 10 minutes after the rTMS session.",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Sham stimulation combined with expressive writing, divided equally to mirror the two active arms","SHAM_COMPARATOR","Sham stimulation will be delivered using a placebo coil that reproduces the acoustic and procedural characteristics of rTMS without producing effective cortical stimulation.\n\nEmotional re-experiencing will be induced through expressive writing. Participants will write for 15 minutes once per week about the thoughts and emotions associated with their traumatic or highly stressful experiences throughout the treatment period. This group will be divided into two halves, each mirroring the timing conditions of each experimental study arm.",[14,24],"Device: Sham rTMS",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Repetitive Transcranial Magnetic Stimulation","rTMS will be administered by an experienced technician using a figure-of-eight coil connected to a Magstim Rapid2 stimulator (Magstim, Whitland, Dyfed, United Kingdom). Target localization will be performed using stereotactic neuronavigation with the frameless BrainSight system (Rogue Research, Canada) and a Polaris infrared tracking system (Northern Digital, Canada).\n\nBefore each session and for each participant, the motor hotspot and resting motor threshold (rMT) will be determined. The hotspot will be defined as the stimulation site over the left primary motor cortex that produces the strongest and most consistent motor-evoked potentials in the first dorsal interosseous muscle, recorded via electromyography using a Biopac MP-35 system.\n\nThe resting motor threshold will be defined as the minimum stimulation intensity capable of eliciting at least five small-amplitude motor responses out of ten stimuli applied to the relaxed muscle. The rTMS intensity will be individually adjusted",[9,16],[32],"rTMS",{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"BEHAVIORAL","Expressive writing","Emotional re-experiencing will be induced through expressive writing. Participants will write for 15 minutes once per week about the thoughts and emotions associated with their traumatic or highly stressful experiences throughout the treatment period (Pennebaker \\& Chung, 2011).",[20,9,16],null,{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":38},"Sham rTMS","Sham stimulation will be delivered using a placebo coil that reproduces the acoustic and procedural characteristics of rTMS without producing effective cortical stimulation.",[20],[44,49],{"name":45,"role":46,"phone":47,"phoneExt":38,"email":48},"Lilisbeth Perestelo-Pérez, Doctor in Psychology","CONTACT","+34 922478267","lilisbeth.peresteloperez@sescs.es",{"name":50,"role":46,"phone":38,"phoneExt":38,"email":51},"Wenceslao Peñate-Castro, Doctor in Psychology","wpenate@ull.edu.es",[53,69],{"facility":54,"status":38,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Instituto Universitario de Neurociencias (IUNE) de la Universidad de La Laguna (ULL)","San Cristóbal de La Laguna","Santa Cruz de Tenerife","38200","Spain","ES",{"type":61,"coordinates":62},"Point",[63,64],-16.32014,28.4853,{"lat":64,"lon":63},[67],{"name":50,"role":46,"phone":68,"phoneExt":38,"email":51},"+34 922 31 74 60",{"facility":70,"status":38,"city":56,"state":56,"zip":71,"country":58,"countryCode":59,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Servicio de Evaluación del Servicio Canario de Salud","38109",{"type":61,"coordinates":73},[74,75],-16.25462,28.46824,{"lat":75,"lon":74},[78],{"name":45,"role":46,"phone":47,"phoneExt":38,"email":48},{"type":80,"investigatorFullName":38,"investigatorTitle":38,"investigatorAffiliation":38,"oldNameTitle":38,"oldOrganization":38},"SPONSOR",[82],{"name":83,"class":6},"University of La Laguna","100636559","efficacy-and-safety-of-repetitive-transcranial-magnetic-stimulation-and-expressive-writing-for-post-traumatic-stress-100636559",false,"NCT07567261","Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation and Expressive Writing for Post-Traumatic Stress","Efficacy and Safety of a Combined Intervention of Repetitive Transcranial Magnetic Stimulation and Expressive Writing According to Timing of Administration: A Parallel-Group Randomized Controlled Trial in Adults With Post-Traumatic Stress Symptoms","Inclusion Criteria:\n\n* Be between 18 and 65 years of age.\n* Have experienced at least one traumatic or highly stressful event, regardless of how much time has passed since the event occurred.\n* Present a score ≥ 24 on the Revised Impact of Event Scale (IES-R).\n* Have post-traumatic stress symptoms that are not better explained by another clinical condition or mental disorder.\n\nExclusion Criteria:\n\n* History of epilepsy, seizures, or convulsions.\n* Presence of intracranial or cranial metal incompatible with rTMS.\n* History of severe traumatic brain injury.\n* Pregnancy or reasonable possibility of pregnancy.\n* Cochlear implants or internal pulse generators.\n* Use of medication that lowers the seizure threshold.\n* Current suicidal ideation or behaviour, or recent suicidal ideation within the past month.\n* Other medical or psychiatric conditions that contraindicate the use of rTMS.\n* Any condition that prevents participation in any of the study interventions.\n* Currently receiving psychological and\u002For pharmacological treatment for PTSD, acute stress, or another disorder that could account for post-traumatic stress symptoms.\n* Failure to provide written informed consent.",true,"ALL","18 Years","65 Years",{"count":96,"type":97},45,"ESTIMATED","INTERVENTIONAL",[100],"NA","The goal of this clinical trial is to learn if a combined treatment using repetitive transcranial magnetic stimulation (rTMS) and expressive writing works to reduce symptoms of post-traumatic stress in adults. It will also study how safe this treatment is and whether the timing of rTMS changes how well it works.\n\nThe main questions it aims to answer are:\n\n* Does this combined treatment lower symptoms of post-traumatic stress?\n* Does it work better when rTMS is given before or after expressive writing?\n\nResearchers will compare three groups to see which approach works best:\n\n* rTMS given before expressive writing\n* rTMS given after expressive writing\n* Sham stimulation (a look-alike procedure that does not provide real stimulation)\n\nParticipants will:\n\n* Take part in sessions that include expressive writing about emotional experiences\n* Receive either real rTMS or sham stimulation\n* Complete questionnaires about post-traumatic stress, anxiety, depression, and mood\n* Have their heart rate and skin responses measured during the sessions\n* Be assessed before the study, after the sessions, and one month later\n\nThis study includes adults aged 18 to 65 who have experienced at least one traumatic or highly stressful event and report symptoms of post-traumatic stress.",[103],"Healthy Adults",[105,32,106,107,108,109],"Post-traumatic stress","randomized controlled trial","repetitive transcranial magnetic stimulation","transcranial magnetic stimulation","TMS","NOT_YET_RECRUITING","2026-04-28",{"date":113,"type":114},"2026-05-05","ACTUAL",{"date":116,"type":97},"2026-06",{"date":118,"type":97},"2027-02",{"name":5,"class":6},2]