[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599814":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":47,"locations":53,"responsibleParty":71,"collaborators":26,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":26,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":26,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":26,"overallStatus":56,"whyStopped":26,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Resveratrol group","EXPERIMENTAL","59 patients will receive the standard treatment for management of RA in addition to Resveratrol 1 gm daily for three month daily.",[13],"Dietary Supplement: Resveratrol 1 gm.",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","ACTIVE_COMPARATOR","59 patients will receive the standard treatment for management of RA for 3 months.",[19],"Drug: Methotrexate",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Resveratrol 1 gm.","59 patients will receive the standard treatment for management of RA in addition to Resveratrol 1 gm daily, (Organix, Egypt) (given as one 1000 mg tablets once daily) for 3 months.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Methotrexate","59 patients will receive the standard treatment for management of RA for 3 months",[15],[33,37,40,44],{"name":34,"affiliation":35,"role":36},"Lamia El-Wakeel, Professor of Clinical Pharmacy","Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University","STUDY_DIRECTOR",{"name":38,"affiliation":39,"role":36},"Sarah Zaki, Professor of Clinical Pharmacy","Clinical Pharmacy Departement, Faculty of Pharmacy, Ain Shams University",{"name":41,"affiliation":42,"role":43},"Al Shymaa Farouk, Lecturer of Internal Medicine","Rheumatology and Clinical Immunology, Faculty of Medicine, Ain Shams University","STUDY_CHAIR",{"name":45,"affiliation":35,"role":46},"Rana El-Dash, Assistant Lecturer","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":26,"email":52},"Rana El-Dash, MsC","CONTACT","+201023669009","rana.mahmoudali@pharma.asu.edu.eg",[54],{"facility":55,"status":56,"city":57,"state":26,"zip":26,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Department of Rheumatology at Ain Shams university hospital, Cairo, Egypt","RECRUITING","Cairo","Egypt","EG",{"type":61,"coordinates":62},"Point",[63,64],31.24967,30.06263,{"lat":64,"lon":63},[67],{"name":68,"role":50,"phone":69,"phoneExt":26,"email":70},"Farouk, Doctoral Degree","+201005225137","alshymaafarouk@gmail.com",{"type":46,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Rana El-Dash","Assistant Lecturer\u002FPharmacist","100599814","efficacy-and-safety-of-resveratrol-in-patients-with-rheumatoid-arthritis-100599814",false,"NCT07089381","Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.","Inclusion Criteria:\n\n* Adult patients \\> 18 years old\n* Established diagnosis of RA according to American College of Rheumatology\u002FEuropean league Against Rheumatism (ACR\u002FEULAR) 2010 criteria (Aletaha et al., 2010), presented with moderate to high disease activity identified as disease activity score-28 based on C-reactive protein (CRP) levels (DAS-28-CRP) \\>3.2.\n* Patients receiving stable regimen of one or more csDMARDs for at least the past 3 months.\n* RA Patients with Moderate or high disease activity identified as disease activity score-28 based on C-reactive protein (CRP) levels (DAS-28-CRP) \\>3.2.\n\nExclusion Criteria:\n\n* Patients receiving biologic DMARDs therapy for RA\n* Patients taking any other anti-inflammatory drugs\n* Patients taking any other antioxidants\n* Pregnant and lactating women\n* Other rheumatological, inflammatory diseases or malignancies\n* Smokers\n* Thyroid illnesses\n* Patients with impaired liver functions (liver transaminases level ≥ three times upper normal limits), impaired kidney functions (estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin)","ALL","18 Years",{"count":83,"type":84},118,"ESTIMATED","INTERVENTIONAL",[87],"NA","The aim of the current study is to evaluate the effects of resveratrol on the clinical outcome(s) of patients with moderate rheumatoid arthritis.\n\nObjectives :\n\n1. To investigate the effects of Resveratrol on inflammation and oxidative stress by measuring:\n\n   * Serum Sirtuin 1(SIRT1)\n   * Serum Myeloperoxidase (MPO)\n   * Serum C-reactive protein (CRP)\n2. To investigate the effects of Resveratrol on disease activity by measuring the disease activity (DAS28 score).\n3. To investigate the effect of Resveratrol on improving the quality of life using the Health Assessment Questionnaire Disability index (HAQ-DI).\n4. To assess any adverse effects related to Resveratrol.\n\nPatients:\n\nEligible patients (no=118) will be randomly assigned in a 1:1 ratio to one of two groups:\n\n1. Control group: 59 patients will receive the standard treatment for management of RA for 3 months.\n2. Resveratrol group: 59 patients will receive the standard treatment for management of RA in addition to Resveratrol 1 gm daily, (Organix Egypt) (given as one 1000 mg tablets once daily) for 3 months.",[90,91,92,93,94,95,96,29,97],"Rheumatic Arthritis","Rheumatoid Arthritis (RA) Prevention","Inflamation","Antioxidant","Anti Oxidative Stress","Anti Aging","C Reactive Protein","Quality of Life Outcomes","2025-07-21",{"date":100,"type":101},"2025-07-28","ACTUAL",{"date":103,"type":84},"2025-08-01",{"date":105,"type":84},"2026-06-01",{"name":5,"class":6},1]