[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554056":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":41,"locations":51,"responsibleParty":71,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":32,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":32,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":32,"overallStatus":54,"whyStopped":32,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"All India Institute of Medical Sciences, Bhubaneswar","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"tACS group","EXPERIMENTAL","10 Hz 2 mA peak-to-peak stimulation will be for 20 minutes, at zero-degree phase difference and zero offset current",[13],"Device: transcranial Alternating current stimulation (tACS)",{"label":15,"type":16,"description":17,"interventionNames":18},"tDCS group","ACTIVE_COMPARATOR","tDCS stimulation: 2 mA stimulation will be applied for 20 minutes",[19],"Device: transcranial Direct current stimulation (tDCS)",{"label":21,"type":22,"description":23,"interventionNames":24},"sham controlled group","SHAM_COMPARATOR","1mA current will be applied for the first 30 seconds, to provide the initial sensation of real stimulation and then the current will be stopped, thus minimizing the stimulatory effects",[25],"Device: Sham controlled",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","transcranial Alternating current stimulation (tACS)","It is a non-invasive brain stimulation technique that uses small, pulsed alternating current (1mA) to modulate lasting cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviours, with proven efficacy in various neuropsychiatric disorders.",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"transcranial Direct current stimulation (tDCS)","It is a non-invasive brain stimulation technique that uses constant, low direct current to modulate lasting cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviours, with proven efficacy in various neuropsychiatric disorders.",[15],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Sham controlled","1mA current will be applied for the first 30 seconds to provide the initial sensation of real stimulation, and then the current will be stopped, thus minimizing the stimulatory effects. It is known to have no effect on psychopathology\u002Fneuro-cognition and means to mimic the tDCS\u002FtACS (in order to help blinding of the participants).",[21],[42,47],{"name":43,"role":44,"phone":45,"phoneExt":32,"email":46},"Biswa R Mishra","CONTACT","09438884220","brm1678@gmail.com",{"name":48,"role":44,"phone":49,"phoneExt":32,"email":50},"Debadatta Mohapatra","09438884221","psych_debadatta@aiimsbhubaneswar.edu.in",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"All India Institute of Medical Scinces - Bhubaneswar","RECRUITING","Bhubaneswar","Odisha","751019","India","IN",{"type":61,"coordinates":62},"Point",[63,64],85.83385,20.27241,{"lat":64,"lon":63},[67,69],{"name":68,"role":44,"phone":45,"phoneExt":32,"email":46},"Biswa R Mishra, MD, DPM",{"name":70,"role":44,"phone":49,"phoneExt":32,"email":50},"Debadatta Mohapatra, MD",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","BISWA RANJAN MISHRA","Additional Professor",[76],{"name":77,"class":78},"Indian Council of Medical Research","OTHER_GOV","100554056","efficacy-and-safety-of-tacs-vs-tdcs-in-schizophrenia-100554056",false,"NCT06494124","Efficacy and Safety of tACS vs tDCS in Schizophrenia","Comparison of Efficacy and Safety of Transcranial Alternating Current Stimulation vs Transcranial Direct Current Stimulation on Psychopathology Measures and Neurocognition in Chronic Schizophrenia: A Randomized Double-blind Controlled Trial","Inclusion Criteria:\n\n1. Diagnosis of Schizophrenia as per ICD-10 DCR for more than 2 years\n2. Moderate-severe symptoms (PANSS score \\> 75 and\u002For CGI-SCH score\\>4) \\[24\\]\n3. On stable dosing of antipsychotic medications (no changes in medication or doses for 1 month prior to enrolment)\n4. Both sexes; Age range: 18-60 years\n5. Right-handed\n6. Written informed consent by the patient\n\nExclusion Criteria:\n\n1. Features suggestive of psychiatric emergency (for example: suicidal risk, catatonia, prolonged nutritional deprivation) or others (for example: aggression or excitement)\n2. Any contraindication to tDCS procedure: Metal in the head, Implanted brain medical devices, Local lesion or injury in the scalp \u002F head\n3. Co-morbid neurological disease\n4. Left Handed","ALL","18 Years","60 Years",{"count":90,"type":91},90,"ESTIMATED","INTERVENTIONAL",[94],"NA","This clinical trial aims to compare the efficacy and safety of transcranial Alternating current stimulation (tACS) vs. transcranial Direct current stimulation (tDCS) vs. sham stimulation in chronic schizophrenia.\n\nThe main question it aims to answer is:\n\n• In comparison to tDCS, can tACS improve the clinical outcome of patients with chronic schizophrenia?\n\nParticipants will be randomised into 3 groups receiving either tDCS, tACS or sham stimulation and changes in psychopathology and neuro-cognition with the interventions will be compared within and between the groups. The primary outcome measure is the Positive and Negative Syndrome Scale (PANSS), while secondary outcome measures are the Auditory Hallucination Rating Scale (AHRS), Brief Cognitive Assessment Tool for Schizophrenia (B-CATS), and Global Assessment of Functioning (GAF).",[97],"Schizophrenia","2024-07-08",{"date":100,"type":101},"2024-07-10","ACTUAL",{"date":103,"type":101},"2024-04-03",{"date":105,"type":91},"2026-06",{"name":5,"class":6},1]