[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637106":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":42,"centralContacts":46,"locations":57,"responsibleParty":76,"collaborators":51,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":51,"eligibilityCriteria":85,"healthyVolunteers":82,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":51,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":105,"whyStopped":51,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tTIS Targeting Left ALIC","ACTIVE_COMPARATOR","Participants in this arm will receive active transcranial temporal interference stimulation (tTIS) targeting the left anterior limb of the internal capsule (ALIC). Treatment will be delivered twice daily for 5 consecutive days, with each session lasting 20 minutes and a 30-minute interval between sessions.",[13],"Device: Active Transcranial Temporal Interference Stimulation Targeting Left ALIC",{"label":15,"type":10,"description":16,"interventionNames":17},"Active tTIS Targeting Left sgACC","Participants in this arm will receive active transcranial temporal interference stimulation (tTIS) targeting the left subgenual anterior cingulate cortex (sgACC). Treatment will be delivered twice daily for 5 consecutive days, with each session lasting 20 minutes and a 30-minute interval between sessions.",[18],"Device: Active Transcranial Temporal Interference Stimulation Targeting Left sgACC",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham tTIS","SHAM_COMPARATOR","Participants in this arm will receive sham transcranial temporal interference stimulation (tTIS). Sham stimulation will be delivered using the same type of device and will provide sensory feedback similar to active stimulation, but it will not provide the same active treatment dose. Treatment sessions will follow the same schedule as the active stimulation arms.",[24],"Device: Sham Transcranial Temporal Interference Stimulation",[26,32,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Active Transcranial Temporal Interference Stimulation Targeting Left ALIC","Participants in this arm will receive active transcranial temporal interference stimulation (tTIS) targeting the left anterior limb of the internal capsule (ALIC). The stimulation target will be individualized based on each participant's magnetic resonance imaging data. The difference frequency will be 130 Hz. Each session will last 20 minutes, twice daily for 5 consecutive days, with a 30-minute interval between sessions.",[9],[9],{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Active Transcranial Temporal Interference Stimulation Targeting Left sgACC","Participants in this arm will receive active transcranial temporal interference stimulation (tTIS) targeting the left subgenual anterior cingulate cortex (sgACC). The stimulation target will be individualized based on each participant's magnetic resonance imaging data. The difference frequency will be 130 Hz. Each session will last 20 minutes, twice daily for 5 consecutive days, with a 30-minute interval between sessions.",[15],[15],{"type":27,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Sham Transcranial Temporal Interference Stimulation","Participants in this arm will receive sham transcranial temporal interference stimulation (tTIS) using the same type of device as active stimulation. Sham stimulation will provide sensory feedback similar to active stimulation to help maintain masking, but it will not deliver the same active treatment dose. Each session will last 20 minutes, twice daily for 5 consecutive days, with a 30-minute interval between sessions.",[20],[20],[43],{"name":44,"affiliation":5,"role":45},"Yonggui Yuan, PhD","PRINCIPAL_INVESTIGATOR",[47,53],{"name":48,"role":49,"phone":50,"phoneExt":51,"email":52},"Yue Zhou, MD Candidate","CONTACT","+86 15651003002",null,"2725106172@qq.com",{"name":54,"role":49,"phone":55,"phoneExt":51,"email":56},"Yubo Zhang, MD Candidate","+86 18651617808","1301053461@qq.com",[58],{"facility":59,"status":51,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Zhongda Hospital Southeast University","Nanjing","Jiangsu","210009","China","CN",{"type":66,"coordinates":67},"Point",[68,69],118.77778,32.06167,{"lat":69,"lon":68},[72,73,75],{"name":48,"role":49,"phone":50,"phoneExt":51,"email":52},{"name":54,"role":49,"phone":74,"phoneExt":51,"email":56},"+86 1865161780",{"name":44,"role":45,"phone":51,"phoneExt":51,"email":51},{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":51,"oldOrganization":51},"SPONSOR_INVESTIGATOR","Yonggui Yuan","Chief Physician","100637106","efficacy-and-safety-of-transcranial-temporal-interference-stimulation-for-depression-100637106",false,"NCT07612501","Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression","Inclusion Criteria:\n\n* Diagnosed with major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), by two independent psychiatrists\n* 24-item Hamilton Depression Rating Scale (HAMD-24) total score greater than 20 at baseline\n* Aged 18 to 65 years\n* Right-handed\n* Able to understand the study procedures and willing to provide written informed consent\n\nExclusion Criteria:\n\n* History of epilepsy, brain tumor, or brain trauma\n* Receipt of transcranial magnetic stimulation, transcranial electrical stimulation, or electroconvulsive therapy within the past 3 months\n* Presence of metal implants or other contraindications to transcranial electrical stimulation or magnetic resonance imaging\n* Acute or severe suicidal ideation\n* Any other condition judged by the investigators to make participation unsuitable for this study","ALL","18 Years","65 Years",{"count":90,"type":91},60,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this clinical trial is to learn whether transcranial temporal interference stimulation (tTIS) can help treat major depressive disorder (MDD) in adults. The study will also learn about the safety of tTIS and explore how it may affect brain structure and brain function.\n\nThe main questions it aims to answer are whether active tTIS lowers depression symptom scores more than sham stimulation after treatment, and what medical problems or side effects participants have during or after tTIS.\n\nResearchers will compare active tTIS targeting the left anterior limb of the internal capsule, active tTIS targeting the left subgenual anterior cingulate cortex, and sham stimulation. Sham stimulation is designed to feel similar to real stimulation but does not provide the same active treatment.\n\nParticipants with MDD will be randomly assigned to one of the three groups. They will receive two 20-minute treatment sessions each day for 5 days. They will complete depression, anxiety, pleasure, psychosomatic symptom, and safety assessments before treatment, after treatment, and during follow-up. They will also have brain magnetic resonance imaging scans before and after treatment.",[97],"Major Depressive Disorder (MDD)",[99,100,101,102,103,104],"Major Depressive Disorder","Transcranial Temporal Interference Stimulation","Noninvasive Brain Stimulation","Anterior Limb of the Internal Capsule","Subgenual Anterior Cingulate Cortex","Magnetic Resonance Imaging","NOT_YET_RECRUITING","2026-05-27",{"date":108,"type":109},"2026-05-28","ACTUAL",{"date":111,"type":91},"2026-05-30",{"date":113,"type":91},"2027-05-30",{"name":78,"class":6},1]