[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100444464":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":74,"collaborators":25,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":25,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Elsan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Aponeurectomy with grafting","EXPERIMENTAL","The experimental group evaluates the aponeurectomy associated with adipose tissue grafting.",[13],"Procedure: Aponeurectomy with grafting",{"label":15,"type":16,"description":17,"interventionNames":18},"Aponeurectomy alone","ACTIVE_COMPARATOR","The control group evaluates the aponeurectomy alone.",[19],"Procedure: Aponeurectomy alone",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","The lipofilling is performed, once the incisions are closed and is performed with the Puregraft® system.\n\nThe fat graft is taken from the posterior, medial and anterior sides of the arm, by skin puncture. Approximately 10 cc are harvested, allowing a reinjection of about 2 cc per digital radius treated. After conditioning, the fat graft is redistributed to the curettage areas through the skin incisions.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"The patient is installed in dorsal decubitus position and the arm to be treated is anesthetized by axillary block. The procedure is performed in the operating room, respecting all the rules of asepsis and safety in force. A tourniquet is placed on the arm to be treated and inflated to 250mmHg. Broken incisions are then made opposite the cords to be excised, which are located by palpation. Once the noble elements have been identified, the excision of the cords and fibrous nodules can be done as completely as possible. Sometimes an arthrolysis procedure is necessary in order to restore extension to a joint that has been fixed in a flexion position for several years. Skin closure is most often possible by direct suture or by means of local fatty skin flaps. In some cases, the surgeon may use total skin grafts, or directed healing in certain areas where direct skin suture is not possible.",[15],[30],{"name":31,"affiliation":32,"role":33},"Elias SAWAYA, MD","Institut Aquitain de la Main","PRINCIPAL_INVESTIGATOR",[35],{"name":31,"role":36,"phone":37,"phoneExt":38,"email":39},"CONTACT","(0)663420278","+33","esawaya.md@gmail.com",[41,60],{"facility":32,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Pessac","33600","France","FR",{"type":48,"coordinates":49},"Point",[50,51],-0.6324,44.80565,{"lat":51,"lon":50},[54,56,59],{"name":55,"role":36,"phone":37,"phoneExt":38,"email":39},"Elias Sawaya, MD",{"name":57,"role":36,"phone":25,"phoneExt":25,"email":58},"Charlène PY, CRA","charlene.py@elsan.care",{"name":55,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":61,"status":42,"city":62,"state":25,"zip":63,"country":45,"countryCode":46,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Santé Atlantique ELSAN","Saint-Herblain","44800",{"type":48,"coordinates":65},[66,67],-1.651,47.21154,{"lat":67,"lon":66},[70],{"name":71,"role":36,"phone":72,"phoneExt":25,"email":73},"Flore-Anne LECOQ, MD","+332 40 95 93 93","recherche.na@elsan.care",{"type":75,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100444464","efficacy-of-aponeurectomy-on-the-2-year-recurrence-rate-of-dupuytrens-disease-100444464",false,"NCT05067764","Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease","Multicenter, Randomized, Open-label Study Evaluating the Efficacy of Aponeurectomy Associated With Adipose Tissue Grafting Compared to Aponeurectomy Alone, on the 2-year Recurrence Rate of Dupuytren's Disease (REMEDY).","REMEDY","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Carrier of Tubiana stage II-IV Dupuytren's disease on at least one or more rays, not previously operated\n* Indication of a surgery by aponeurectomy\n* Skin pinch of the posterior aspect of the arm of more than 1cm\n* Affiliation to a social security system\n* Patient informed of the study and having given informed consent\n\nExclusion Criteria:\n\n* Previous surgery of any kind for Dupuytren's disease\n* Involvement on the thumb only\n* Need for a total skin graft or a pedicle flap on all the rays to be treated\n* Active autoimmune disease\n* Previous treatment with collagenase\n* Pregnant and breastfeeding women\n* Patient under legal protection\n* Contraindications to MRI (criteria applicable only for patients from the coordinating center, not applicable for other centers)","ALL","18 Years",{"count":87,"type":88},172,"ESTIMATED","INTERVENTIONAL",[91],"NA","Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis which cuts the hypodermic fatty tissue, adheres to the skin and the phalanges, gradually bending the affected rays, resulting in significant functional impotence.\n\nVarious medical and surgical treatments are available.",[94],"Dupuytren's Disease","2026-04-20",{"date":97,"type":98},"2026-04-23","ACTUAL",{"date":100,"type":98},"2022-09-29",{"date":102,"type":88},"2030-03-29",{"name":5,"class":6},2]