[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640652":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":35,"locations":41,"responsibleParty":56,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":10,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"early rhythm control group",null,"Patients who received rhythm control therapy(include catheter ablation, cardioversion, anti-arrhythmic drugs) within 2 years of new-onset atrial fibrillation",[13,14],"Drug: Anti-arrhythmic drugs for rhythm control","Procedure: DC cardioversion, catheter ablation for rhythm control",{"label":16,"type":10,"description":17,"interventionNames":18},"Usual care group","Patients who received usual care include rate control therapy without early rhythm control intervention within 2 years of new-onset atrial fibrillation",[19],"Other: Usual care",[21,26,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DRUG","Anti-arrhythmic drugs for rhythm control","flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone",[9],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"PROCEDURE","DC cardioversion, catheter ablation for rhythm control","Direct-current cardioversion may be performed to acutely restore sinus rhythm, particularly in patients with persistent atrial fibrillation or symptomatic rhythm deterioration. Catheter ablation may be considered as a more definitive rhythm-control strategy to reduce atrial fibrillation burden and maintain sinus rhythm over the long term.",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Usual care","General management without atrial fibrillation rhythm control treatment.(Observation without additional medication, or heart rate control treatment if necessary)",[16],[36],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Ju Youn Kim, Ph.D","CONTACT","82+ 10-5482-7307","kzzoo921@gmail.com",[42],{"facility":5,"status":43,"city":44,"state":44,"zip":45,"country":46,"countryCode":10,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Seoul","06351","South Korea",{"type":48,"coordinates":49},"Point",[50,51],126.9784,37.566,{"lat":51,"lon":50},[54],{"name":37,"role":38,"phone":55,"phoneExt":10,"email":40},"82+ 2-3410-3419",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ju Youn Kim","MD, PhD","100640652","efficacy-of-early-rhythm-control-in-af-with-tr-patients-100640652",false,"NCT07607093","Efficacy of Early Rhythm Control in AF With TR Patients","TRAF","Inclusion Criteria:\n\n* Patients with concomitant atrial fibrillation and tricuspid regurgitation.\n\nExclusion Criteria:\n\n* Patients with a history of valvular surgery\n* Patients with congenital heart disease\n* Patients with primary pulmonary hypertension\n* Patients with CIED implantation prior to the diagnosis of tricuspid regurgitation\n* Patients diagnosed with TR only after the initiation of rhythm control therapy for AF","ALL",{"count":69,"type":70},5800,"ESTIMATED","OBSERVATIONAL","Atrial fibrillation is frequently accompanied by tricuspid regurgitation and may contribute to right atrial and tricuspid annular remodeling, leading to progression of tricuspid regurgitation and adverse clinical outcomes. However, whether early rhythm control improves prognosis in patients with atrial fibrillation and tricuspid regurgitation remains unclear. This study will compare early rhythm control with usual care in these patients, using a composite outcome of cardiac death, heart failure admission, stroke, and tricuspid valve surgery.",[74,75],"Atrial Fibrillation (AF)","Tricuspid Regurgitation (TR)",[77],"early rhythm control","2026-05-27",{"date":80,"type":81},"2026-05-29","ACTUAL",{"date":83,"type":81},"2026-02-18",{"date":85,"type":70},"2027-02-28",{"name":5,"class":6},1]