[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627335":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":62,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":26,"enrollmentInfo":89,"targetDuration":26,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":100,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"early rhythm control group","EXPERIMENTAL","Early rhythm control group receives atrial fibrillation rhythm control treatment based on guidelines. This includes antiarrhythmic treatment, cardioversion, and catheter ablation.\n\nAntiarrhythmic drugs include flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone and so on, and the doctor chooses the drug in consideration of structural heart disease, coronary artery disease, abnormal left ventricular hypertrophy, and heart failure.(Refer to the Korean Heart rhythm Society atrial Fibrillation Treatment Guidelines) Catheter ablation is a procedure that uses high-frequency energy to block the site of tachycardia in the heart. Cardioversion is a procedure that converts the electrical activity of the heart to sinus rhythm by directly giving electric shock on the surface of the heart. Catheter ablation or cardioversion is a treatment method performed only when clinical atrial fibrillation is confirmed.",[13,14],"Drug: early rhythm control group","Procedure: cardioversion, catheter ablation",{"label":16,"type":17,"description":18,"interventionNames":19},"general control group","ACTIVE_COMPARATOR","The general control group receives general management without the above atrial fibrillation rhythm control treatment.(Observation without additional medication, or heart rate control treatment if necessary) Heart rate control drugs such as beta-blockers, calcium channel blockers (Non-dihydropyridine CCB), and digoxin are used for heart rate control according to the doctor's prescription.",[20],"Other: general control",[22,27,32],{"type":23,"name":9,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","flecainide, propafenone, pilsicainide, sotalol, amiodarone, dronedarone and so on",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","cardioversion, catheter ablation","only when clinical atrial fibrillation (if atrial fibrillation continued for more than 30 seconds on a 12-lead electrocardiogram or holter monitoring) is confirmed",[9],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":26},"general control","General management without atrial fibrillation rhythm control treatment.(Observation without additional medication, or heart rate control treatment if necessary) Heart rate control drugs such as beta-blockers, calcium channel blockers (Non-dihydropyridine CCB), and digoxin are used for heart rate control according to the doctor's prescription.",[16],[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Ju Youn Kim, Clinical assistant professor, MD, Ph.D","CONTACT","82-2-3410-3419","kzzoo921@gmail.com",[43],{"facility":5,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":26,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Seoul","06351","South Korea",{"type":49,"coordinates":50},"Point",[51,52],126.9784,37.566,{"lat":52,"lon":51},[55],{"name":56,"role":39,"phone":57,"phoneExt":26,"email":41},"Kim Ju Youn, Clinical assistant professor, Ph.D","82+ 2-3410-3419",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Ju Youn Kim","Associate professor",[63,65,67,69,72,74,76,78],{"name":64,"class":6},"Korea University Guro Hospital",{"name":66,"class":6},"Korea University Anam Hospital",{"name":68,"class":6},"Keimyung University Dongsan Medical Center",{"name":70,"class":71},"Sinchon Severance Hospital, Yonsei University College of Medicine","UNKNOWN",{"name":73,"class":6},"Wonju Severance Christian Hospital",{"name":75,"class":6},"Asan Medical Center",{"name":77,"class":6},"Inje University Ilsan Paik Hospital",{"name":79,"class":6},"The Catholic University of Korea","100627335","efficacy-of-early-rhythm-control-therapy-in-patients-with-subclinical-atrial-fibrillation-100627335",false,"NCT07447297","Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation","SubclincalAF","Inclusion Criteria:\n\n* Among patients with Cardiac implantable electronic device (CIED), subjects with atrial high rate episodes found Cardiac implantable electronic devices: implantable loop recorder, pacemaker, implantable cardioverter defibrillator(ICD), cardiac resynchronized therapy(CRT)\n* Patients aged 19 or older who have agreed to the study (if voluntary consent is deemed difficult, consent from legal representatives is obtained together)\n* If the accumulated period of the atrial high rate episode during the three-month observation period is more than 21 hours\n* Patients whose atrial fibrillation has not been confirmed by electrocardiogram or holter monitoring within the past year from the time atrial high rate episode was detected\n\nHowever, enrollment is possible even if it includes one of the following two cases ⓐ Patients diagnosed and recorded as atrial fibrillation on medical records but not confirmed by electrocardiogram or holter monitoring\n\nⓑ If there is a record of atrial fibrillation, but Paroxysmal AF less than 30 seconds\n\nExclusion Criteria:\n\n* Patients deemed inappropriate to participate in the study by the investigator\n* Patients diagnosed with atrial fibrillation with 12-lead electrocardiogram or holter within the past year prior to participation in the study\n* Patients taking Class Ic, III of antiarrhythmic drugs prior to study participation\n* Patients who have had rhythm control treatments such as Radiofequency catheter ablation (RFCA), Total thoracoscopic ablation (TTA), Maze procedure (MAZEop), and antiarrhythmic treatment due to atrial fibrillation (except for CTI ablation with AFL)\n* Patients whose life expectancy is less than one year (e.g., patients who can't even have a heart transplant, patients who receive DNR, Patients in hospice wards who refuse life-sustaining treatment, terminal cancer patients who cannot receive radiation or chemotherapy, etc.)","ALL","19 Years",{"count":90,"type":91},520,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this study to find out the efficacy of early rhythm therapy in patients with subclinical atrial fibrillation detected by Cardiac Electronic Implantable Devices.\n\nEarly rhythm therapy includes antiarrhythmic drug, cardioversion, and catheter ablation. The general control group receives general management without the above atrial fibrillation rhythm control treatment.\n\nResearchers will compare early rhythm control groups to general control groups to see if early rhythm therapy works to reduce the atrial fibrillation burden by 50% or more, or decrease the incidence of clinical AF documentation.\n\nParticipants will:\n\n* Randomly allocated to two groups at a 1:1 ratio.\n* Receive the treatment according to their assigned group.\n* Visit the clinic once every three months for checkups and tests.",[97,98,99],"Atrial Fibrillation (AF)","Diseases of the Circulatory System","Atrial Flutter",[101,102,103],"earl rhythm control","subclinical atrial fibrillation","antiarrhythmic drugs","2026-02-27",{"date":106,"type":107},"2026-03-03","ACTUAL",{"date":109,"type":107},"2024-01-02",{"date":111,"type":91},"2029-12-31",{"name":5,"class":6},1]