[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597791":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":47,"centralContacts":63,"locations":69,"responsibleParty":84,"collaborators":31,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":31,"eligibilityCriteria":92,"healthyVolunteers":89,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":31,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":108,"whyStopped":31,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Cairo University","OTHER",[8,15,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Erythromycin Phonophoresis + Medical treatment","EXPERIMENTAL","This group will include 30 patients with chronic rhinosinusitis who will receive Erythromycin phonophoresis 12 session, 3 days per week, and medical treatment (saline nasal wash) 3 times daily for a month.",[13,14],"Other: Erythromycin Phonophoresis","Other: Medical treatment",{"label":16,"type":17,"description":18,"interventionNames":19},"Ultrasound + Topical Erythromycin + Medical treatment","ACTIVE_COMPARATOR","This group will include 30 patients with chronic rhinosinusitis who will receive ultrasound followed by topical use of Erythromycin gel on nose 12 session , 3 days per week and medical treatment (saline nasal wash) 3 times daily for a month.",[20,21,14],"Device: Ultrasound (US)","Drug: Topical Erythromycin",{"label":23,"type":6,"description":24,"interventionNames":25},"Medical treatment","This group includes 30 patients with chronic rhinosinusitis who will receive their medical treatment (saline nasal wash) 3 times daily for a month",[14],[27,32,37,44],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Erythromycin Phonophoresis","The procedures of ultrasound phonophoresis will be as follows: Patients will be positioned comfortably, sitting in a relaxed position. The physiotherapist will explain the treatment procedures to the patient. The device cables will be checked before each session. The treatment will last 5 minutes for each maxillary sinus. The frequency will be set to 1 MHz, and the intensity will be 1 W\u002FCm2 for the maxillary sinuses. The ultrasound will be pulsed, and the treatment will consist of 12 sessions, 3 days per week.",[9],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"DEVICE","Ultrasound (US)","Therapeutic US is produced by a transducer composed of a piezoelectric crystal, which converts electric energy into alternating compression and rarefaction of sound waves at a frequency greater than 20 kHz. The amplitude of the US wave is proportional to the displacement of the US transducer head during each half cycle. The amplitude represents the wave energy.\n\nThe ultrasound waves penetrate the tissue on the way to the target organ and have two mechanisms of action (thermal and non-thermal), which may potentially work synergistically to reduce nasal symptoms (nasal blockage and secretions).",[16],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"DRUG","Topical Erythromycin","Erythromycin is a 14-member macrolide originally discovered in the 1950s. It has broad-spectrum antimicrobial action, inhibiting bacterial protein synthesis. studies have shown that erythromycin has immunomodulatory and anti-inflammatory activity independent of its antimicrobial action Erythromycin is a broad-spectrum macrolide antibiotic, wherein its bactericidal effect occurs by the inhibition of protein synthesis. It is used for the treatment of infections affecting the skin and mucosa; it shows immunomodulatory characteristics",[16],[43],"Erythromycin",{"type":6,"name":23,"description":45,"armGroupLabels":46,"otherNames":31},"Saline nasal wash 3 times daily for a month.",[9,23,16],[48,52,56,60],{"name":49,"affiliation":50,"role":51},"Nahla Mahmoud Elkassas, B.Sc","Physotherapist at Alexanderia Police Hospital","PRINCIPAL_INVESTIGATOR",{"name":53,"affiliation":54,"role":55},"Hussein Gamal Hussein Mogahed, PhD","Assistant Professor, Cairo university","STUDY_CHAIR",{"name":57,"affiliation":58,"role":59},"Mustafa Mohamed Abdelnaby, PhD","Assistant Professor, Alexandria university","STUDY_DIRECTOR",{"name":61,"affiliation":62,"role":59},"Aya Gamal Fawzy Elsayed, PhD","Lecturer, Cairo university",[64,68],{"name":49,"role":65,"phone":66,"phoneExt":31,"email":67},"CONTACT","01555996909","elkassasnahla@gmail.com",{"name":61,"role":65,"phone":31,"phoneExt":31,"email":31},[70],{"facility":71,"status":31,"city":72,"state":31,"zip":31,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Alexanderia Police Hospital","Alexandria","Egypt","EG",{"type":76,"coordinates":77},"Point",[78,79],29.91582,31.20176,{"lat":79,"lon":78},[82],{"name":49,"role":65,"phone":66,"phoneExt":31,"email":83},"elkassasnahla@gemail.com",{"type":51,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"nahla mahmoud mohamed elkassas","Principal Investigator","100597791","efficacy-of-erythromycin-phonophoresis-on-chronic-rhinosinusitis-100597791",false,"NCT07063082","Efficacy Of Erythromycin Phonophoresis on Chronic Rhinosinusitis","Inclusion Criteria:\n\n* Age range between 25-50 years.\n* Male and female patients will participate in the study.\n* All patients have chronic rhinosinusitis.\n* All patients enrolled in the study will have their informed consent.\n* CT will include at least affection of maxillary sinus.\n\nExclusion Criteria:\n\n* Patients with pacemaker\n* Patients diagnosed with cancer.\n* Pregnant women\n* Patients with impaired vascular circulation\n* Patients who suffer from mental or psychological disorders.\n* Patients with any systemic diseases that may interfere with the objectives of the study.\n* Congenital defects on face and nose.\n* Fracture of nose or face.\n* Polypoidal patients.\n* Allergic patients.\n* Previous nasal surgery.","ALL","25 Years","50 Years",{"count":97,"type":98},90,"ESTIMATED","INTERVENTIONAL",[101],"NA","The purpose of the study is to evaluate the therapeutic effect of erythromycin phonophoresis in reducing chronic rhinosinusitis.",[104],"Chronic Rhinosinusitis",[43,106,107],"Phonophoresis","ultrasound","NOT_YET_RECRUITING","2025-07-02",{"date":111,"type":112},"2025-07-14","ACTUAL",{"date":114,"type":98},"2025-07-07",{"date":116,"type":98},"2025-09-15",{"name":5,"class":6},1]