[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599704":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":38,"responsibleParty":54,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":83,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"40Hz music group","EXPERIMENTAL","The 40Hz music is combined with 40Hz sound and music.",[13],"Device: Gamma auditory stimulation device (active setting)",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-40Hz music group","SHAM_COMPARATOR","The non-40Hz music is combined with non-40Hz sound and music.",[19],"Device: Gamma auditory stimulation device (sham setting)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Gamma auditory stimulation device (active setting)","Participants will receive auditory stimulation using the gamma auditory stimulation device (active setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Gamma auditory stimulation device (sham setting)","Participants will receive auditory stimulation using the gamma auditory stimulation device (sham setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Chia-Hsiung Cheng, Ph.D.","CONTACT","+886-3-211800","3854","ch.cheng@mail.cgu.edu.tw",[39],{"facility":40,"status":26,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Chang Gung University","Taoyuan","Guishan","33302","Taiwan","TW",{"type":47,"coordinates":48},"Point",[49,50],121.29696,24.99368,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},{"type":55,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100599704","efficacy-of-gamma-auditory-stimulation-for-cognitive-decline-in-older-adults-study-1-100599704",false,"NCT07087951","Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)","Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)","Inclusion Criteria:\n\n1. Age over 60 years old.\n2. MMSE≤ 24\n3. CDR scores of 0.5 and 1\n4. Voluntary to sign the Informed Consent Form.\n\nExclusion Criteria:\n\n1. Diagnosis of other psychiatric or neurological disorders\n2. Drug or alcohol addictions.\n3. Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.\n4. History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.","ALL","60 Years",{"count":66,"type":67},70,"ESTIMATED","INTERVENTIONAL",[70],"NA","Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.",[73,74,75],"EEG Brain Oscillations","Alzheimer's Disease (AD) and Related Disorders","Cognitive Dysfunction",[77,78,79,80,81,82],"endogenous gamma","EEG rhythms","resting-state EEG (rs-EEG)","Alzheimer's disease (AD)","Cognitive function","auditory stimulation","NOT_YET_RECRUITING","2025-08-10",{"date":86,"type":87},"2025-08-14","ACTUAL",{"date":89,"type":67},"2025-09-01",{"date":91,"type":67},"2028-09-01",{"name":5,"class":6},1]