[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595436":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":40,"collaborators":42,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":26,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":76,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":26},{"fullName":5,"class":6},"Magnetic Tides","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active kTMP","EXPERIMENTAL","Participants received 8 V\u002Fm of active stimulation",[13],"Device: A new non-invasive brain stimulation tool",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham kTMP","SHAM_COMPARATOR","Participants received 0.0 V\u002Fm of sham stimulation",[19],"Device: A new non-invasive brain stimulation tool with sham setting selected",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","A new non-invasive brain stimulation tool","kTMP is a magnetic induction method that delivers continuous kHz-frequency cortical electric fields (E-fields) which may be amplitude-modulated to potentially mimic electrical activity at endogenous frequencies which will be tested on anhedonia patients in this study.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"A new non-invasive brain stimulation tool with sham setting selected","This device will counterbalance the active kTMP conditions",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Ludovica Labruna","CONTACT","14155137265","labruna@magnetictides.com",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},"Christina Merrick","merrick@magnetictides.com",{"type":41,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[43],{"name":44,"class":45},"University of California, San Francisco","OTHER","100595436","efficacy-of-ktmp-a-novel-non-invasive-brain-stimulation-method-for-the-treatment-of-anhedonia-100595436",false,"NCT07032428","Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia","kTMP Anhedonia","Inclusion Criteria: (1) Patients 21-80 years of age with clinically significant anhedonia, as defined by a SHAPS score of at least 20, and (2) Meet DSM-VTR diagnostic criteria for Major Depressive Disorder.\n\nExclusion Criteria:(1) Reason to anticipate possible hospitalization during the course of the study; (2) Current\u002Fhistory of a psychotic disorder, current manic or mixed episode, meeting the DSM-VTR criteria for bipolar disorder, post-traumatic stress disorder, schizophrenia, at screening, autism spectrum disorders, or mental retardation; (3) Meet DSM-VTR criteria for a substance use disorder within the last year; (4) Current suicidal ideation, suicidal ideation with intent, plan or attempt within the last year, or are considered at significant risk for suicide during the study; (5) Use of any drugs\u002Fmedications that may interfere\u002Finteract with the expected outcomes of the study within 5 half-lives of study participation (see Human Subject section for details); (6) History of seizure; (7) Intracranial expansive process; (8) Pacemaker or any metal implants in head\u002Fneck region; (9) Pregnancy; (10) Uncontrolled medical problems including but not limited to severe cardiovascular and cardiopulmonary disease, severe alcohol or drug abuse within the past year; (11) Contraindications for non-invasive brain stimulation or magnetic resonance imaging procedures; (12) Any other condition that in the opinion of the investigator would preclude participation in the study.","ALL","21 Years","80 Years",{"count":57,"type":58},104,"ESTIMATED","INTERVENTIONAL",[61],"NA","The goal of this proposal is to provide a first assessment of the efficacy of our innovative non-invasive brain stimulation system, kTMP, in the treatment of anhedonia in MDD.",[64,65],"Anhedonia","Major Depressive Disorder (MDD)",[67,68,69,70,71,72,73,74,75],"kTMP","NIBS","anhedonia","Major Depressive Disorder","Cortical Excitability","Plasticity","Neuroscience","reward network","kilohertz Transcranial Magnetic Perturbation","NOT_YET_RECRUITING","2026-06-18",{"date":79,"type":80},"2026-06-23","ACTUAL",{"date":82,"type":58},"2026-07-15",{"date":84,"type":58},"2028-07-30",{"name":5,"class":6}]