[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568670":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":40,"locations":47,"responsibleParty":65,"collaborators":45,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":45,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":45,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":50,"whyStopped":45,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Zagazig University","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nerve Block Therapy","EXPERIMENTAL","Participants in this group will receive supratrochlear and greater occipital nerve injections consisting of a combination of local anesthetics and corticosteroids. Injections will be administered once every 12 weeks for a total of 6 months.",[13],"Procedure: Nerve Block Injections",{"label":15,"type":16,"description":17,"interventionNames":18},"Botulinum Toxin A (Botox) Therapy","ACTIVE_COMPARATOR","Participants in this group will receive Botulinum toxin A (Botox) injections according to the standard PREEMPT injection protocol for chronic migraine. Injections will be administered once every 12 weeks for a total of 6 months.",[19],"Drug: Botulinum Toxin A",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Nerve Block Injections","This intervention involves the administration of supratrochlear and greater occipital nerve block injections. The injections consist of a mixture of local anesthetics and corticosteroids, designed to reduce the frequency and severity of migraine episodes. The procedure will be repeated every 12 weeks for a total duration of 6 months to assess the long-term efficacy and safety in managing chronic migraine.",[9],[27],"Supratrochlear and Greater Occipital Nerve Block",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Botulinum Toxin A","Participants in this arm will receive Botulinum toxin A injections as per the PREEMPT protocol tailored for chronic migraine treatment. The treatment involves multiple injections around the head and neck regions, administered every 12 weeks over a 6-month period. This standard approach aims to reduce migraine frequency through neuromodulation of pain pathways.",[15],[34],"Botox",[36],{"name":37,"affiliation":38,"role":39},"Ahmed Bessar, MD, PhD","Assistant Professor of Diagnostic and Interventional Radiology, Zagazig Uni.","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Ahmed A Bessar, MD, PhD","CONTACT","+201000089595",null,"Ahmedawadbessar@gmail.com",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Zagazig University, Faculty of Medicine","RECRUITING","Zagazig","Sharqia Province","44519","Egypt","EG",{"type":57,"coordinates":58},"Point",[59,60],31.502,30.58768,{"lat":60,"lon":59},[63],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":64},"ahmedawadbessar@gmail.com",{"type":39,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Ahmed Awad Bessar","Assistant Professor of Diagnostic and Interventional Radiology","100568670","efficacy-of-nerve-block-versus-botox-in-chronic-migraine-management-100568670",false,"NCT06684249","Efficacy of Nerve Block Versus Botox in Chronic Migraine Management","A Randomized Controlled Trial Comparing the Efficacy of Supratrochlear and Greater Occipital Nerve Blocks to Botulinum Toxin A in the Management of Chronic Migraine","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Diagnosis of chronic migraine, defined as having headaches on 15 or more days per month for more than three months, with at least 8 of those days meeting criteria for migraine.\n* Ability to provide informed consent and comply with study requirements.\n* No changes in prophylactic migraine medications in the last 3 months.\n\nExclusion Criteria:\n\n* History of allergy or hypersensitivity to local anesthetics or Botulinum toxin.\n* Previous nerve block or Botox treatment within the last 6 months.\n* Significant comorbid psychiatric or neurological disorders that could interfere with study participation or evaluation.\n* Pregnancy or breastfeeding.\n* Contraindications to either treatment as per product labels.","ALL","18 Years","65 Years",{"count":79,"type":80},64,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic migraine in adults.\n\nThe main questions it aims to answer are:\n\n* Do nerve block injections reduce the number of monthly migraine days compared to baseline?\n* Are there any differences in the frequency of migraine-related symptoms between the nerve block and Botox treatment groups?\n* Which treatment leads to higher patient satisfaction and improved quality of life?\n\nParticipants in this study will:\n\n* Receive either nerve block injections or Botox injections every 12 weeks.\n* Visit the clinic once every month for follow-ups and assessments.\n* Maintain a headache diary to record the frequency and severity of their migraines and any adverse effects experienced.\n* Researchers will compare the outcomes of the two groups to determine if one treatment is superior in terms of efficacy and patient satisfaction.",[86,87],"Chronic Migraine","Chronic Migraine, Headache",[89,86,90,91,34,92],"Migraine","Nerve Block","Botulinum Toxin","Headache","2024-11-10",{"date":95,"type":96},"2024-11-12","ACTUAL",{"date":93,"type":96},{"date":99,"type":80},"2025-07-10",{"name":5,"class":6},1]