[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536854":3},{"organization":4,"armGroups":7,"interventions":40,"overallOfficials":59,"centralContacts":63,"locations":72,"responsibleParty":87,"collaborators":90,"id":110,"slug":111,"hasResults":112,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":45,"eligibilityCriteria":116,"healthyVolunteers":112,"sex":117,"minAge":118,"maxAge":45,"enrollmentInfo":119,"targetDuration":45,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":74,"whyStopped":45,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14,20,25,30,35],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Frequency1","EXPERIMENTAL","Confirmed responses in TMS-induced MEP: Preserved ipsilateral corticospinal tract.\n\nHigh-frequency rTMS over ipsilateral primary motor cortex will be applied.",[13],"Device: High-Frequency1",{"label":15,"type":16,"description":17,"interventionNames":18},"cTBS1","ACTIVE_COMPARATOR","Confirmed responses in TMS-induced MEP: Preserved ipsilateral corticospinal tract.\n\ncontinous Theta Burst Stimulation (cTBS) protocol of rTMS over contralateral primary motor cortex will be applied.",[19],"Device: cTBS1",{"label":21,"type":10,"description":22,"interventionNames":23},"High-Frequency2","Absent responses in TMS-induced MEPs, but confirmed corticospinal tract integrity in DTI; Preserved ipsilateral alternative corticospinal tract.\n\nHigh-frequency rTMS over ipsilateral premotor cortex will be applied.",[24],"Device: High-Frequency2",{"label":26,"type":16,"description":27,"interventionNames":28},"cTBS2","Absent responses in TMS-induced MEPs, but confirmed corticospinal tract integrity in DTI; Preserved ipsilateral alternative corticospinal tract.\n\ncontinous Theta Burst Stimulation (cTBS) protocol of rTMS over contralateral primary motor cortex will be applied.",[29],"Device: cTBS2",{"label":31,"type":10,"description":32,"interventionNames":33},"High-Frequency3","Absent responses in all ipsilateral corticospinal tract.\n\nHigh-frequency rTMS over contralateral primary motor cortex will be applied.",[34],"Device: High-Frequency3",{"label":36,"type":16,"description":37,"interventionNames":38},"cTBS3","Absent responses in all ipsilateral corticospinal tract.\n\ncontinous Theta Burst Stimulation (cTBS) protocol of rTMS over contralateral primary motor cortex will be applied.",[39],"Device: cTBS3",[41,46,49,52,54,57],{"type":42,"name":9,"description":43,"armGroupLabels":44,"otherNames":45},"DEVICE","rTMS intervention: 20 sessions of 10-Hz rTMS at 90% resting motor threshold (RMT), 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.\n\nrTMS target: ipsilateral primary motor cortex.\n\nTotal rTMS sessions: once a day, 5 days per week, for 2 weeks, totaling 10 sessions.\n\nAdditional treatment: inpatient conventional rehabilitation therapy, consisting of occupational and physical therapy for 30 minutes each, twice daily, for 2 weeks, as well as the routine pharmacotherapy based on the guidelines for management of patients with stroke.",[9],null,{"type":42,"name":15,"description":47,"armGroupLabels":48,"otherNames":45},"rTMS intervention: 40 seconds of cTBS at 70% RMT, totaling 600 pulses.\n\nrTMS target: contralateral primary motor cortex.\n\nTotal rTMS sessions: once a day, 5 days per week, for 2 weeks, totaling 10 sessions.\n\nAdditional treatment: inpatient conventional rehabilitation therapy, consisting of occupational and physical therapy for 30 minutes each, twice daily, for 2 weeks, as well as the routine pharmacotherapy based on the guidelines for management of patients with stroke.",[15],{"type":42,"name":21,"description":50,"armGroupLabels":51,"otherNames":45},"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% RMT, 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.\n\nrTMS target: ipsilateral premotor cortex.\n\nTotal rTMS sessions: once a day, 5 days per week, for 2 weeks, totaling 10 sessions.\n\nAdditional treatment: inpatient conventional rehabilitation therapy, consisting of occupational and physical therapy for 30 minutes each, twice daily, for 2 weeks, as well as the routine pharmacotherapy based on the guidelines for management of patients with stroke.",[21],{"type":42,"name":26,"description":47,"armGroupLabels":53,"otherNames":45},[26],{"type":42,"name":31,"description":55,"armGroupLabels":56,"otherNames":45},"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% RMT, 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.\n\nrTMS target: contralateral primary motor cortex.\n\nTotal rTMS sessions: once a day, 5 days per week, for 2 weeks, totaling 10 sessions.\n\nAdditional treatment: inpatient conventional rehabilitation therapy, consisting of occupational and physical therapy for 30 minutes each, twice daily, for 2 weeks, as well as the routine pharmacotherapy based on the guidelines for management of patients with stroke.",[31],{"type":42,"name":36,"description":47,"armGroupLabels":58,"otherNames":45},[36],[60],{"name":61,"affiliation":5,"role":62},"Won Hyuk Chang, PhD","PRINCIPAL_INVESTIGATOR",[64,68],{"name":61,"role":65,"phone":66,"phoneExt":45,"email":67},"CONTACT","82-2-3410-6068","wh.chang@samsung.com",{"name":69,"role":65,"phone":70,"phoneExt":45,"email":71},"Ho Seok Lee, PhD","82-2-3410-2810","hoseok89.lee@samsung.com",[73],{"facility":5,"status":74,"city":75,"state":45,"zip":76,"country":77,"countryCode":45,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"RECRUITING","Seoul","06351","South Korea",{"type":79,"coordinates":80},"Point",[81,82],126.9784,37.566,{"lat":82,"lon":81},[85],{"name":61,"role":65,"phone":86,"phoneExt":45,"email":67},"+82-2-3410-6068",{"type":62,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Won Hyuk Chang","Professor",[91,93,96,98,100,102,104,107],{"name":92,"class":6},"National Research Foundation of Korea",{"name":94,"class":95},"Ministry of Food and Drug Safety, Korea","OTHER_GOV",{"name":97,"class":6},"Seoul National University Hospital",{"name":99,"class":6},"Bucheon St. Mary's Hospital",{"name":101,"class":6},"Saint Vincent's Hospital, Korea",{"name":103,"class":6},"Severance Hospital",{"name":105,"class":106},"Kumoh National Institute of Technology","UNKNOWN",{"name":108,"class":109},"NEUROPHET","INDUSTRY","100536854","efficacy-of-personalized-repetitive-transcranial-magnetic-stimulation-protocol-based-on-functional-reserve-to-enhance-upper-limb-function-in-subacute-stroke-patients-100536854",false,"NCT06270238","Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients","Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients: A Multi Center, Randomized, Single Blind, Parallel Group Prospective Clinical Trial","Inclusion Criteria:\n\n1. hemiplegic stroke patients in the subacute phase (7 days to 3 months from the onset) who are currently hospitalized,\n2. FMA score of the upper extremity ≤42,\n3. adequate language and cognitive function to perform at least a 1-step obey-command,\n4. pre-stroke functional level of modified Rankin Scale (mRS) ≤1,\n5. aged ≥19 years old,\n6. patients willing to sign the informed consent.\n\nExclusion Criteria:\n\n1. those with contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or a history of craniotomy,\n2. those with progressive of hemodynamically unstable medical conditions,\n3. those with coexisting neurological conditions, such as spinal cord injury or Parkinson's disease,\n4. those with major psychiatric disorders, such as major depression, schizophrenia, or dementia,\n5. those having contraindications to conduct an MRI study,\n6. those who are pregnant or lactating ,\n7. patients who have refused to participate in this study.","ALL","19 Years",{"count":120,"type":121},120,"ESTIMATED","INTERVENTIONAL",[124],"NA","The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each hemiplegic stroke patient in subacute phase, compared to conventional low-frequency rTMS therapy on contralateral M1. Investigators hypothesized that the functional reserve of each hemiplegic stroke patient will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to stroke patients regardless of their severity, predicted mechanism of motor function recovery, or functional reserves.",[127],"Stroke",[127,129,130],"rTMS","Functional reserve","2026-04-23",{"date":133,"type":134},"2026-04-24","ACTUAL",{"date":136,"type":134},"2024-02-13",{"date":138,"type":121},"2026-09-30",{"name":5,"class":6},1]