[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617517":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":58,"collaborators":18,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":84,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Case Group","EXPERIMENTAL","The group in which PRF will be placed over mental nerve during open reduction and internal fixation of patients with mandibular body fractures involving mental foramen.",[13],"Other: Platelets rich Fibrin",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","The group in which PRF will not be placed over mental nerve during open reduction and internal fixation of patients with mandibular body fractures.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Platelets rich Fibrin","PRF is the second generation autologous platelet concentrate that is obtained from patient's own blood in simple and cost effective manner. PRF is comprised of three main specifications. First, the existence of platelets and their active growth factors i.e. platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor (TGF), insulin-like growth factor (IGF) and epidermal growth factor (EGF). Second, the role of leukocytes and cytokines i.e. TNF alpha, IL-6 and IL-1ɓ in anti-inflammatory response and immune modulation. Third, the fibrin meshwork where these platelets, cytokines and growth factors are embedded and subsequently released after a short period",[9],[25],"PRF",[27],{"name":28,"affiliation":29,"role":30},"Dr Gulraiz Zulfiqar, FCPS(OMFS)","Associate professor and Head of Department Oral & Maxillofacial Surgery, Allama Iqbal Medical College\u002F Jinnah Hospital Lahore","STUDY_DIRECTOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Muhammad Umair Shakir, PGR MDS (OMFS)","CONTACT","+92 3127916610","umair446109@gmail.com",[38],{"facility":39,"status":18,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Allama Iqbal Medical College\u002F Jinnah Hospital Lahore","Lahore","Punjab Province","54550","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],74.35071,31.558,{"lat":49,"lon":48},[52,56],{"name":53,"role":34,"phone":54,"phoneExt":18,"email":55},"Dr Gulraiz Zulfiqar, FCPS (OMFS)","+92 321 4559970","gulraizoms@yahoo.com",{"name":33,"role":57,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Muhammad umair shakir","Postgraduate Resident (MDS) Oral & Maxillofacial Surgery","100617517","efficacy-of-platelet-rich-fibrin-prf-in-neurosensory-disturbance-among-patients-with-mandibular-body-fractures-100617517",false,"NCT07319650","Efficacy Of Platelet Rich Fibrin (PRF) In Neurosensory Disturbance Among Patients With Mandibular Body Fractures","PRF NSD","Inclusion Criteria:\n\n* Patients having neurosensory disturbance following mandibular body fracture involving mental foramen and pre-operative TPD discrimination score '0' or '1' will be selected in this study ( as per operational definition). TPD discrimination will be recorded; Preoperatively Immediately post operatively After 6 months\n\nAge 15-40years, Both Gender ASA\\_1\n\nExclusion Criteria:\n\n* Comminuted mandibular fractures Previously treated cases of fractures Patients with history of neurological disorders Comorbid patients","ALL","15 Years","40 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","Mandibular body fractures frequently result in inferior alveolar nerve (IAN) and mental nerve injuries which ultimately leads to paresthesia of chin and lower lip area. The objective of this study is to evaluate the efficacy of platelet rich fibrin (PRF) application to mental nerve during open reduction and internal fixation (ORIF) of patients having neurosensory disturbance (NSD) following mandibular body fracture involving mental foramen. The PRF application to mental nerve in mandibular body fractures will not only aid in hard and soft tissue healing but also prove to be a game changer for a holistic healing of a patient rather than separate surgical procedures for nerve repair such as microsurgery, grafting, tissue glues, laser.\n\nAlternate Hypothesis HA= The application of PRF to the mental nerve during open reduction and internal fixation of mandibular body fractures involving the mental foramen significantly improves neurosensory recovery compared to cases where PRF is not applied.\n\nNull Hypothesis HO= The application of PRF to the mental nerve during open reduction and internal fixation of mandibular body fractures involving the mental foramen does not significantly improve neurosensory recovery compared to cases where PRF is not applied.",[79,80],"Neurosensory Disturbance","Mandibular Body Fractures",[79,82,83],"Platelet Rich Fibrin","Mandibular body fractures","NOT_YET_RECRUITING","2025-12-20",{"date":87,"type":88},"2026-01-06","ACTUAL",{"date":90,"type":73},"2026-01",{"date":92,"type":73},"2027-02",{"name":5,"class":6},1]