[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586847":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":115,"collaborators":26,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":26,"eligibilityCriteria":123,"healthyVolunteers":119,"sex":124,"minAge":125,"maxAge":26,"enrollmentInfo":126,"targetDuration":26,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":26,"overallStatus":136,"whyStopped":26,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIC group","EXPERIMENTAL","Subjects in the RIC group receive standard therapy and RIC treatment.",[13],"Device: RIC",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-RIC group","SHAM_COMPARATOR","Subjects in the Sham-RIC group receive standard therapy and Sham-RIC treatment.",[19],"Device: Sham-RIC",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","RIC","The ischemic preconditioning training device is applied to the subjects' upper arms to administer pressure (200 mmHg). The pressure is maintained for 5 minutes, followed by 5 minutes of release, completing one ischemia-reperfusion cycle. Each training session consists of 5 consecutive cycles, performed twice daily for 14 days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham-RIC","The ischemic preconditioning training device is applied to the subjects' upper arms to administer pressure (60 mmHg). The pressure is maintained for 5 minutes, followed by 5 minutes of release, completing one ischemia-reperfusion cycle. Each training session consists of 5 consecutive cycles, performed twice daily for 14 days.",[15],[32],{"name":33,"affiliation":5,"role":34},"Lina Jia","STUDY_DIRECTOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+8615901588600","lnjia@ccmu.edu.cn",{"name":41,"role":37,"phone":42,"phoneExt":26,"email":43},"Shuling Wan","+8615901589718","15901589718@163.com",[45,62,76,90,104],{"facility":46,"status":26,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Tongren City People's Hospital","Tongren","Guizhou","554399","China","CN",{"type":53,"coordinates":54},"Point",[55,56],109.18528,27.71722,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":61,"phoneExt":26,"email":26},"Long Liao","+8615121644332",{"facility":63,"status":26,"city":64,"state":65,"zip":66,"country":50,"countryCode":51,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Baoding People's Hospital","Baoding","Hebei","071030",{"type":53,"coordinates":68},[69,70],115.46246,38.87288,{"lat":70,"lon":69},[73],{"name":74,"role":37,"phone":75,"phoneExt":26,"email":26},"Lan Hou","+8613931239934",{"facility":77,"status":26,"city":78,"state":79,"zip":80,"country":50,"countryCode":51,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Jilin People's Hospital","Jilin City","Jilin","132001",{"type":53,"coordinates":82},[83,84],126.5608,43.84652,{"lat":84,"lon":83},[87],{"name":88,"role":37,"phone":89,"phoneExt":26,"email":26},"Zhifei Wang","+8618104421807",{"facility":91,"status":26,"city":92,"state":93,"zip":94,"country":50,"countryCode":51,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Jincheng People's Hospital","Jincheng","Shanxi","048028",{"type":53,"coordinates":96},[97,98],112.83278,35.50222,{"lat":98,"lon":97},[101],{"name":102,"role":37,"phone":103,"phoneExt":26,"email":26},"Lina Xu","+8613835628289",{"facility":105,"status":26,"city":106,"state":26,"zip":107,"country":50,"countryCode":51,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Xuanwu Hospital, Capital Medical University","Beijing","100053",{"type":53,"coordinates":109},[110,111],116.39723,39.9075,{"lat":111,"lon":110},[114],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"type":116,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100586847","efficacy-of-remote-ischemic-conditioning-in-preventing-post-stroke-depression-100586847",false,"NCT06920706","Efficacy of Remote Ischemic Conditioning in Preventing Post-Stroke Depression","Efficacy of Remote Ischemic Conditioning in Preventing Post-Stroke Depression: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial","Inclusion Criteria:\n\n* Patient age≥18 years;\n* No gender preference;\n* Diagnosed with acute ischemic stroke;\n* From onset to treatment ≤48 h;\n* 6≤ NIHSS scores ≤25;\n* Premorbid mRS ≤1;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Baseline HAMD-24 scores ≥8;\n* Infarction area overlapped with the area where the DTI-ALPS index is calculated;\n* A history of severe mental illness such as depression, bipolar disorder, and schizophrenia;\n* A history of mental disorders caused by other organic diseases, such as post-Parkinson depression;\n* Participants with cognitive impairment, disturbance of consciousness, severe hearing impairment, or aphasia who were unable to cooperate with the assessment;\n* A history of autoimmune diseases (such as multiple sclerosis, neuromyelitis optica spectrum disorders, systemic lupus erythematosus, etc.), malignant tumors, or obstructive sleep apnea hypopnea syndrome;\n* Intracranial tumor, arteriovenous malformation, or aneurysm;\n* Uncontrolled severe hypertension (systolic pressure \\>180mmHg or diastolic pressure \\>110 mmHg after drug treatment) ;\n* Subclavian artery stenosis≥50% or subclavian steal syndrome;\n* Any contraindication for remote ischemic adaptation: the upper limb has serious soft tissue injury, fracture or vascular injury, distal upper limb perivascular lesions, etc.;\n* Severe coagulation dysfunction, platelet count \\\u003C 100×10\\^9\u002FL, cardiac dysfunction (NYHA class Ⅲ or above), hepatic dysfunction (aspartate aminotransferase and\u002For alanine aminotransferase \\> 3 times the upper limit of normal), or renal dysfunction (serum creatinine \\> 265μmol\u002FL);\n* Any contraindication for magnetic resonance imaging: metal implants, claustrophobia, etc.;\n* Women known to be pregnant or lactating, or have a positive pregnancy test;\n* Participating in other clinical trials within three months;\n* Participants not suitable for this clinical studies considered by researcher.","ALL","18 Years",{"count":127,"type":128},240,"ESTIMATED","INTERVENTIONAL",[131],"NA","Post-stroke depression (PSD) is characterized primarily by low mood and loss of interest following a stroke. It is one of the most common and serious complications of stroke, with an incidence of 11% to 41% within two years post-stroke. PSD significantly impacts stroke prognosis, not only hindering neurological recovery but also increasing clinical disability and mortality rates, thereby imposing substantial economic and psychological burdens on families and society. Therefore, preventing PSD is crucial for stroke rehabilitation.\n\nClinical trials have demonstrated that preventive antidepressant treatment can reduce PSD incidence and improve clinical outcomes; however, controversies remain regarding the timing, methods, and safety. Meanwhile, preventive psychological therapy faces challenges in implementation due to effectiveness, accessibility, and cost-effectiveness.\n\nRemote ischemic preconditioning (RIC) is a non-invasive, cost-effective, and non-pharmacological intervention. By modulating small molecules in the peripheral and central nervous systems through transient, periodic limb blood flow restriction and reperfusion, RIC reverses neurobiological changes and demonstrates neuroprotective potential in various neurological diseases. Recently, a study showed that RIC is safe and effective in preventing PSD; however, the sample size is small and the specific mechanisms remain unclear. Therefore, this study aims to further explore the role and mechanisms of RIC in PSD prevention.",[134,135],"Post-stroke Depression","Remote Ischemic Conditioning","NOT_YET_RECRUITING","2025-04-02",{"date":139,"type":140},"2025-04-10","ACTUAL",{"date":139,"type":128},{"date":143,"type":128},"2026-12-31",{"name":5,"class":6},5]