[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622332":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":58,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":85,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"October University for Modern Sciences and Arts","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A: Nano-Silver Fluoride","EXPERIMENTAL","Topical application of Nano-Silver Fluoride varnish containing silver nanoparticles, chitosan, and fluoride applied to active dentin caries lesions in primary molars. Application will be performed twice: at baseline and after 6 months, without caries excavation or restoration.",[13],"Drug: Nano-Silver Fluoride",{"label":15,"type":16,"description":17,"interventionNames":18},"Arm B: Silver Diamine Fluoride","ACTIVE_COMPARATOR","Topical application of 38% Silver Diamine Fluoride varnish applied to active dentin caries lesions in primary molars. Application will be performed twice: at baseline and after 6 months, without caries excavation or restoration.",[19],"Drug: Silver Diamine Fluoride",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Nano-Silver Fluoride","Chitosan (28,585 μg\u002Fml), Silver (376.5 μg\u002Fml) and Sodium fluoride (5028.3 μg\u002Fml)",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Silver Diamine Fluoride","38% Silver Diamine Fluoride",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Khaled Abdelmonem Sayed Assistant Lecturer at Pediatric Dentistry Department, Master Holder","CONTACT","+201114537612","kasayed@msa.edu.eg",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Faculty of Dentistry, MSA University","Giza","Giza Governorate","12611","Egypt","EG",{"type":46,"coordinates":47},"Point",[48,49],31.20861,30.00944,{"lat":49,"lon":48},[52,55],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":36},"Khaled Abdelmonem, Master degree","01114537612",{"name":56,"role":57,"phone":26,"phoneExt":26,"email":26},"khaled Abdelmonem, master degree","PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"khaled sayed","lecturer assistant at pediatric dentistry department- faculty of dentistry- October University for Modern Sciences and Arts -","100622332","efficacy-of-silver-diamine-fluoride-versus-nano-silver-fluoride-in-arresting-active-dentin-caries-in-primary-teeth-in-young-children-100622332",false,"NCT07382245","Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children","Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Apparently healthy children.\n* Children with age ranged from 3-5 years from both genders.\n* Children who refused dental treatment with Frankl Behavior Rating Scale 1 and 2.\n* Children having molars with active dentin caries score (2,3,4) according to International Caries Detection and Assessment System- ICDAS II, detected by visual and tactile.\n* Parents\u002Fguardians accept treatment and write informed consent.\n\nExclusion Criteria:\n\n* Children with allergy to silver from their medical history.\n* Children with ulcerative gingivitis.\n* Children with primary molars with the following criteria:\n* Symptomatic\n* Involving the pulp\n* Presence of fistula or sinus\n* Presence of gingival inflammation and Pain on percussion\n* Close to exfoliation","ALL","3 Years","5 Years",{"count":72,"type":73},60,"ESTIMATED","INTERVENTIONAL",[76],"NA","Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration.\n\nThis randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.",[79,80],"Early Childhood Caries (ECC)","Active Dentin Caries in Primary Molars",[82,83,23,28,84],"Early Childhood Caries","primary molar","SDF","NOT_YET_RECRUITING","2026-01-25",{"date":88,"type":89},"2026-02-02","ACTUAL",{"date":91,"type":73},"2026-01-30",{"date":93,"type":73},"2026-03-15",{"name":5,"class":6},1]