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9QP",{"type":62,"coordinates":1275},[1276,1277],-1.13169,52.6386,{"lat":1277,"lon":1276},[1280,1283],{"name":1281,"role":49,"phone":11,"phoneExt":11,"email":1282},"Jude Fisher","jude.a.fisher@uhl-tr.nhs.uk",{"name":1284,"role":42,"phone":11,"phoneExt":11,"email":11},"Bhavik Modi, MD",{"facility":1286,"status":55,"city":1287,"state":11,"zip":1288,"country":1182,"countryCode":1183,"cosmosGeoPoint":1289,"geoPoint":1293,"contacts":1294},"Liverpool Heart and Chest Hospital NHS Foundation Trust","Liverpool","L14 3PE",{"type":62,"coordinates":1290},[1291,1292],-2.97794,53.41058,{"lat":1292,"lon":1291},[1295,1298],{"name":1296,"role":49,"phone":11,"phoneExt":11,"email":1297},"Maureen Baker","maureen.baker@lhch.nhs.uk",{"name":1299,"role":42,"phone":11,"phoneExt":11,"email":11},"Joel Giblett, MD",{"facility":1301,"status":55,"city":1302,"state":11,"zip":1303,"country":1182,"countryCode":1183,"cosmosGeoPoint":1304,"geoPoint":1308,"contacts":1309},"Barts Health Centre","London","E1 1FR",{"type":62,"coordinates":1305},[1306,1307],-0.12574,51.50853,{"lat":1307,"lon":1306},[1310,1313],{"name":1311,"role":49,"phone":11,"phoneExt":11,"email":1312},"Pedro Pinto","p.pinto1@nhs.net",{"name":1314,"role":42,"phone":11,"phoneExt":11,"email":11},"Anthony Mathur, MD",{"facility":1316,"status":55,"city":1302,"state":11,"zip":1317,"country":1182,"countryCode":1183,"cosmosGeoPoint":1318,"geoPoint":1320,"contacts":1321},"Royal Free Hospital","NW3 2QG",{"type":62,"coordinates":1319},[1306,1307],{"lat":1307,"lon":1306},[1322,1325],{"name":1323,"role":49,"phone":11,"phoneExt":11,"email":1324},"Nina Arnold","Nina.arnold@nhs.net",{"name":1326,"role":42,"phone":11,"phoneExt":11,"email":11},"Tushar Kotecha, MD",{"facility":1328,"status":55,"city":1302,"state":11,"zip":1329,"country":1182,"countryCode":1183,"cosmosGeoPoint":1330,"geoPoint":1332,"contacts":1333},"St. Thomas Hospital","SE1 7EH",{"type":62,"coordinates":1331},[1306,1307],{"lat":1307,"lon":1306},[1334,1337],{"name":1335,"role":49,"phone":11,"phoneExt":11,"email":1336},"Sophie Arnold","sophie.arnold5@nhs.net",{"name":1338,"role":42,"phone":11,"phoneExt":11,"email":11},"Tiffany Patterson, MD",{"facility":1340,"status":55,"city":1302,"state":11,"zip":1341,"country":1182,"countryCode":1183,"cosmosGeoPoint":1342,"geoPoint":1344,"contacts":1345},"King's College Hospital","SE5 9RS",{"type":62,"coordinates":1343},[1306,1307],{"lat":1307,"lon":1306},[1346,1349],{"name":1347,"role":49,"phone":11,"phoneExt":11,"email":1348},"Michelle Andrews","michelle.andrews1@nhs.net",{"name":1350,"role":42,"phone":11,"phoneExt":11,"email":11},"Jonathan Byrne, MD",{"facility":1352,"status":55,"city":1302,"state":11,"zip":1353,"country":1182,"countryCode":1183,"cosmosGeoPoint":1354,"geoPoint":1356,"contacts":1357},"St. Georges University Hospital","SW17 0QT",{"type":62,"coordinates":1355},[1306,1307],{"lat":1307,"lon":1306},[1358,1361],{"name":1359,"role":49,"phone":11,"phoneExt":11,"email":1360},"Vennessa Sookhoo","vsookhoo@sgul.ac.uk",{"name":1362,"role":42,"phone":11,"phoneExt":11,"email":11},"James Spratt, MD",{"facility":1364,"status":55,"city":1302,"state":11,"zip":1365,"country":1182,"countryCode":1183,"cosmosGeoPoint":1366,"geoPoint":1368,"contacts":1369},"Royal Brompton Hospital","SW3 6NP",{"type":62,"coordinates":1367},[1306,1307],{"lat":1307,"lon":1306},[1370,1373],{"name":1371,"role":49,"phone":11,"phoneExt":11,"email":1372},"Marcus Farias","m.farias1@rbht.nhs.uk",{"name":1374,"role":42,"phone":11,"phoneExt":11,"email":11},"Ranil De Silva, MD",{"facility":1376,"status":55,"city":1302,"state":11,"zip":1377,"country":1182,"countryCode":1183,"cosmosGeoPoint":1378,"geoPoint":1380,"contacts":1381},"Imperial College Healthcare NHS Trust","W12 0HS",{"type":62,"coordinates":1379},[1306,1307],{"lat":1307,"lon":1306},[1382,1385],{"name":1383,"role":49,"phone":11,"phoneExt":11,"email":1384},"Maricris Tuason","maricris.tuason@nhs.net",{"name":1386,"role":42,"phone":11,"phoneExt":11,"email":11},"Rasha Al-Lamee, MD",{"facility":1388,"status":55,"city":1389,"state":11,"zip":1390,"country":1182,"countryCode":1183,"cosmosGeoPoint":1391,"geoPoint":1395,"contacts":1396},"Freeman Hospital","Newcastle upon Tyne","NE7 7DN",{"type":62,"coordinates":1392},[1393,1394],-1.61396,54.97328,{"lat":1394,"lon":1393},[1397,1400],{"name":1398,"role":49,"phone":11,"phoneExt":11,"email":1399},"Laura Gordon","l.gordon7@nhs.net",{"name":1401,"role":42,"phone":11,"phoneExt":11,"email":11},"Bilal Bawamia, MD",{"facility":1403,"status":55,"city":1404,"state":11,"zip":1405,"country":1182,"countryCode":1183,"cosmosGeoPoint":1406,"geoPoint":1410,"contacts":1411},"Nottingham University Hospital","Nottingham","NG5",{"type":62,"coordinates":1407},[1408,1409],-1.15047,52.9536,{"lat":1409,"lon":1408},[1412,1415],{"name":1413,"role":49,"phone":11,"phoneExt":11,"email":1414},"Jane Quinn","jane.quinn7@nhs.net",{"name":1416,"role":42,"phone":11,"phoneExt":11,"email":11},"Andrew Vanezis, MD",{"facility":1418,"status":55,"city":1419,"state":11,"zip":1420,"country":1182,"countryCode":1183,"cosmosGeoPoint":1421,"geoPoint":1425,"contacts":1426},"Oxford University Hospital","Oxford","OX3 9DU",{"type":62,"coordinates":1422},[1423,1424],-1.25596,51.75222,{"lat":1424,"lon":1423},[1427,1430],{"name":1428,"role":49,"phone":11,"phoneExt":11,"email":1429},"Anisha Shaji","anisha.shaji@ouh.nhs.uk",{"name":1431,"role":42,"phone":11,"phoneExt":11,"email":11},"Giovanni De Maria, MD",{"facility":1433,"status":55,"city":1434,"state":11,"zip":1435,"country":1182,"countryCode":1183,"cosmosGeoPoint":1436,"geoPoint":1440,"contacts":1441},"Royal Bournemouth Hospital","Poole","BH15 2JB",{"type":62,"coordinates":1437},[1438,1439],-1.98458,50.71429,{"lat":1439,"lon":1438},[1442,1445],{"name":1443,"role":49,"phone":11,"phoneExt":11,"email":1444},"Tanith Changuion","t.changuion@nhs.net",{"name":1446,"role":42,"phone":11,"phoneExt":11,"email":11},"Peter O'Kane, MD",{"facility":1448,"status":55,"city":1449,"state":11,"zip":1450,"country":1182,"countryCode":1183,"cosmosGeoPoint":1451,"geoPoint":1455,"contacts":1456},"Musgrove Park Hospital","Taunton","TA1 5DA",{"type":62,"coordinates":1452},[1453,1454],-3.10293,51.01494,{"lat":1454,"lon":1453},[1457,1460],{"name":1458,"role":49,"phone":11,"phoneExt":11,"email":1459},"Helen Mills","cvresearchteam@somersetft.nhs.uk",{"name":1461,"role":42,"phone":11,"phoneExt":11,"email":11},"Mohammad Sahebjalal, MD",{"type":1463,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100447098","efficacy-of-the-coronary-sinus-reducer-in-patients-with-refractory-angina-ii-100447098",false,"NCT05102019","Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II","COSIRA-II","Inclusion Criteria:\n\n1. Subject is older than 18 years of age\n2. Symptomatic coronary artery disease (CAD) with greater than or equal to 90 days of persistent refractory angina pectoris classified as CCS Grade III or IV despite maximally tolerated guideline directed medical therapy as determined by the local heart team and confirmed by a Central Screening Eligibility Committee Note: subjects may also have exertional dyspnea, but the symptoms that limit activity must be anginal in nature (including chest pain, pressure, heaviness, discomfort, with or without radiation to the neck, jaw, shoulders, arms, or other location) and not dyspnea\n3. Must have attempted treatment with the maximally tolerated dose of at least three of the four (preferably all four) approved classes of anti-anginal agents: long-acting nitrates, calcium channel blockers (either a dihydropyridine or a non-dihydropyridine), beta blockers, and ranolazine. The regimen must be stable for at least 30 days prior to enrollment, must remain stable from enrollment to randomization, and there must be no intent to change the medical regimen for at least 12 months after randomization Note: If the dose of a medication was increased or decreased for a temporary period and then returned to the original dose, which will then be continued for at least 12 months after randomization, the subject may be immediately enrolled without needing to otherwise requalify\n4. Subject has either no treatment options for revascularization by coronary artery bypass grafting or by percutaneous coronary intervention, or is otherwise unsuitable or high risk for revascularization as determined by the local heart team, and confirmed by a Central Screening Eligibility Committee\n5. Evidence of either exercise or pharmacologically induced reversible ischemia severity by stress echo, nuclear study, PET, perfusion MRI, CT perfusion, FFR-CT, FFR, iFR, or other non-hyperemic FDA approved tests (such as diastolic hyperaemia free ratio \\[DRF\\] or resting full-cycle ratio \\[RFR\\] in the distribution of the left coronary artery (LCA), performed within 12 months prior to enrollment Note: If the subject has evidence of ischemia in both the LCA and RCA distributions, the extent of ischemia must be greater in the LCA distribution Note: The qualifying assessment must be performed after any myocardial infarction, CABG, or successful PCI within the prior 12 months. For subjects with multiple assessments, the one performed closest to enrollment will serve as the qualifying study\n6. Functional limitation due to refractory angina as defined by a modified Bruce exercise tolerance test duration of greater than or equal to 2 minutes but less than or equal to 10 minutes, performed while the subject is maintained on their stable regimen of maximally tolerated doses of anti-anginal medications Note: The ETT variability must be less than 20% between last two ETTs performed.\n7. Left ventricular ejection fraction (LVEF) greater than or equal to 30% within the 12-months prior to enrollment Note: The LVEF must be reassessed after any intervening myocardial infarction. For subjects with multiple assessments, the most recent LVEF assessment is used as the qualifying test.\n8. Subject is willing and able to sign informed consent\n9. Subject is willing to comply with the specified follow-up evaluations\n\nAngiographic Inclusion Criteria:\n\n1\\) Three-vessel coronary angiography performed within 12 months prior to enrollment demonstrating obstructive CAD (visually estimated diameter stenosis of ≥70% or ≥50% - \\\u003C70% with fractional flow reserve (FFR) value of ≤0.80 or an iFR or other FDA-approved\u002Fcleared non-hyperemic physiological assessment (such as DFR or RFR) of ≤0.89 in one or more lesions) in the left coronary artery (main epicardial vessels or branches) that is not suitable for and will not be treated with PCI or CABG as determined by the local heart team Note: The qualifying 3-vessel angiogram must be performed after any myocardial infarction, PCI, or CABG within the 12 months prior to enrollment. For patients with multiple 3-vessel angiograms, the one performed closest to enrollment will serve as the qualifying study\n\nExclusion Criteria:\n\n1. Recent (within 30 days prior to enrollment) troponin or CKMB positive acute coronary syndrome (NSTEMI or STEMI) Note: subjects with an elevated troponin or CKMB without acute coronary syndrome may still be enrolled\n2. Recent successful revascularization by either CABG or PCI within six months prior to enrollment\n\n   Note: Successful revascularization is defined as any CABG procedure, or any PCI procedure with a reduction of one or more lesions to \\\u003C50% diameter stenosis\n\n   Note: Subjects with successful revascularization by either CABG or PCI that occurred less than six months prior to enrollment may still be approved for participation in the trial if revascularization was completed six months prior to procedure and CSEC approves subject participation\n3. Recent unsuccessful PCI (e.g., failed attempt to open a chronic total occlusion) within 30 days prior to enrollment\n\n   Note: Subjects with unsuccessful PCI that occurred less than 30 days prior to enrollment may still be approved for participation in the trial if PCI was completed 30 days prior to procedure and CSEC approves subject participation\n4. The predominant manifestation of angina is dyspnea\n\n   Note: some dyspnea may be present with exertion, but the predominant symptom that limits activity must be angina (i.e., chest pain, pressure, tightness, heaviness, or discomfort, with or without radiation to the neck, jaw, shoulders, arms, or other location)\n5. Has extra-coronary contributory causes of angina - e.g., untreated hyperthyroidism, untreated anemia (hgb \\\u003C10 g\u002FdL), uncontrolled hypertension (systolic blood pressure \\>160 mmHg or diastolic blood pressure \\>100 mmHg despite medications), atrial fibrillation with rapid ventricular response (consistently \\>100 bpm despite medications) or other tachyarrhythmia, severe aortic stenosis, hypertrophic cardiomyopathy with left ventricular outflow tract obstruction or asymmetric septal hypertrophy (concentric left ventricular hypertrophy is not an exclusion criterion), or epicardial vasospasm disease\u002Fcoronary artery vasospasm (CAS)\u002Fvasospastic angina (VSA)\n6. NYHA Class III or IV heart failure (HF), decompensated HF or hospitalization due to HF during the 90 days prior to enrollment\n7. Life threatening rhythm disorders or any rhythm disorders that would require future placement of an internal defibrillator and\u002For pacemaker\n8. Severe chronic obstructive pulmonary disease (COPD) as indicated by a forced expiratory volume in one second (FEV1) that is less than 55% of the predicted value, or need for home daytime oxygen or oral steroids\n9. Severe valvular heart disease (any valve)\n10. Moderate or severe RV dysfunction by echocardiography\n11. Pacemaker electrode\u002Flead is present in the coronary sinus\n12. A Class I indication is present for an implantable defibrillator or cardiac resynchronization therapy according to ACCF\u002FAHA\u002FHRS guidelines\n13. Recent implantation of a new pacemaker or defibrillator lead with electrode in the right atrium within 90 days of enrollment\n14. Chronic severe renal failure (estimated eGFR less than 30 mL\u002Fmin\u002F1.73m2 by the MDRD formula) or subjects on chronic dialysis\n15. Known allergy to stainless steel or nickel\n16. Any clinical condition that might interfere with the trial protocol or the subject's ability to be compliant with the trial protocol (e.g., active alcohol or drug abuse, dementia, magnetic resonances imaging (MRI) planned within 8 weeks of procedure)\n17. Currently enrolled in another investigational device or drug trial that has not reached its primary endpoint or that might clinically interfere with the current trial endpoints or procedures\n18. Pregnant or planning pregnancy within the next 12 months (women of reproductive potential must have a negative pregnancy test within 7 days of the procedure)\n19. Subject is part of a vulnerable population who, in the judgment of the investigator, is unable to give Informed Consent for reasons of incapacity, immaturity, adverse personal circumstances or lack of autonomy. This may include individuals with mental disability, persons in nursing homes, children, impoverished persons, persons in emergency situations, homeless persons, nomads, refugees, and those incapable of giving informed consent. Vulnerable populations also may include members of a group with a hierarchical structure such as university students, subordinate hospital and laboratory personnel, employees of the Sponsor, members of the armed forces, and persons kept in detention.\n20. Inability to tolerate dual antiplatelet therapy for 6 months if not on a chronic oral anticoagulant, or inability to tolerate a P2Y12 inhibitor for at least 6 months if on a chronic oral anticoagulant\n21. Comorbidities limiting life expectancy to less than one year\n22. Subject is currently hospitalized for definite or suspected COVID-19\n23. Subject has previously been symptomatic with or hospitalized for COVID-19 and has been asymptomatic for \\\u003C8 weeks prior to enrollment or has not returned to his or her prior baseline (pre-COVID-19) clinical condition\n24. Subject is asymptomatic but has had a positive PCR or antigen test for COVID-19 within the past 4 weeks prior to enrollment\n\nAngiographic\u002FHemodynamic Exclusion Criteria:\n\n1\\) Coronary anatomy amenable to revascularization of ischemic myocardial territory by either PCI or CABG with at least moderate likelihood of long-term alleviation of angina or angina equivalent symptoms, as per the assessment of the local heart team.\n\nNote: If a pathway to coronary revascularization is present which, in the opinion of the local heart team, is reasonably low risk and reasonably likely to provide long-term symptom relief and the subject refuses the revascularization procedure, the patient is ineligible for randomization\n\nProcedural Angiographic\u002FHemodynamic Randomization Exclusion Criteria:\n\n1. Mean right atrial pressure greater than 15 mmHg assessed during the final screening procedure for eligibility assessment and potential randomization\n2. Anomalous or abnormal CS anatomy (e.g., tortuosity, aberrant branch, persistent left superior vena cava \\[SVC\\]) as demonstrated by angiogram\n3. The CS diameter at the most proximal end of the planned implant region (2-4 cm distal to the coronary sinus ostium) is less than 9.5 mm or greater than 13.0 mm\n\nSingle-arm Registry (Unblinded, Non-Randomized Treatment Arm) Inclusion\u002FExclusion Criteria:\n\nSubject can be included in the single-arm registry if they fall into one of the three categories with inclusions and exclusion criteria as described below.\n\nPredominant right coronary disease subjects (RCA):\n\n1. Reversible ischemia: Subjects with evidence of either exercise or pharmacologically induced reversible ischemia by stress echo, nuclear study, PET, perfusion MRI, CT perfusion, FFR-CT, FFR, iFR, or other non-hyperemic FDA approved or cleared tests (such as DFR or RFR) in the distribution of the right coronary artery (RCA), performed within 12 months prior to enrollment.\n\n   Note: If the subject has evidence of ischemia in both the LCA and RCA distributions, the extent of ischemia must be greater in the RCA distribution\n\n   Note: The qualifying assessment must be performed after any myocardial infarction, CABG, or successful PCI within the prior 12 months. If the anti-anginal medication regimen is permanently changed after the assessment of ischemia, the test must be repeated. For subjects with multiple assessments, the one performed closest to enrollment will serve as the qualifying study\n2. Obstructive CAD: Three-vessel coronary angiography performed within the 12 months prior to enrollment demonstrating obstructive CAD (visually assessed diameter stenosis of ≥70% or ≥50% - \\\u003C70% with fractional flow reserve (FFR) value of ≤0.80 or an iFR or other FDA-approved\u002Fcleared non-hyperemic physiological assessment (such as DFR or RFR) of ≤0.89 in one or more lesions) in the RCA (main epicardial vessels or branches) that is not suitable for and will not be treated with PCI or CABG as determined by the local heart team.\n\n   Note: The qualifying assessment must be performed after any myocardial infarction, PCI or CABG within the prior 12 months. For subjects with multiple assessments, the one performed closest to enrollment will serve as the qualifying study\n3. In addition to the above inclusion criteria, subjects must meet all inclusion criteria (except clinical inclusion #5 and angiographic inclusion #1) and none of the exclusion criteria of the main randomized trial\n\nNon-obstructive coronary artery disease subjects (ANOCA)\n\n1. Abnormal Coronary Flow Reserve (CFR): subjects must have either abnormal PET CFR (\\\u003C 2.0), abnormal perfusion CMR (cardiac MRI) CFR (\\\u003C1.85), or abnormal invasive CFR (\\\u003C2.5) in at least one main epicardial coronary artery performed within 12 months prior to enrollment\n\n   Note: Subjects may or may not have evidence of either exercise or pharmacologically induced reversible ischemia by stress echo, nuclear study, PET, perfusion MRI, or CT perfusion\n2. Non-obstructive CAD: subjects have non-obstructive coronary disease (estimated diameter stenosis in all coronary lesions is \\\u003C50% and (if performed) FFR ≥0.81 or a non-hyperemic test is ≥0.90) demonstrated on three-vessel coronary angiography performed within the 12 months prior to enrollment. If an estimated diameter stenosis is ≥50% to \\\u003C70%, the patient may still qualify if FFR ≥0.81 or a non-hyperemic test is ≥0.90 in that vessel. If both FFR and a non-hyperemic test are performed, both must be negative.\n\n   Note: The qualifying 3-vessel angiogram must be performed after any myocardial infarction, PCI or CABG within the 12 months prior to enrollment. For patients with multiple 3-vessel angiograms, the one performed closest to enrollment will serve as the qualifying study\n3. In addition to the above inclusion criteria, subjects must meet all inclusion criteria (except clinical inclusion #5 and angiographic inclusion #1) and none of the exclusion criteria of the main randomized trial\n\nSubjects unable to complete ETT\n\n1. Subjects must be unable to complete the required COSIRA-II exercise tolerance test due to lower limb amputation (above the ankle) or other physiologic condition with documented chronic mobility or balance issues that require the use of a walking aid (e.g., wheelchair, cane, rollator, crutches, or knee walker).\n2. In addition to the above inclusion criteria, subjects must meet all inclusion criteria (except clinical inclusion #6) and none of the exclusion criteria of the main randomized trial\n\nPrior to inclusion in single-arm registry, all subjects will be reviewed by the Central Screening Eligibility Committee to ensure that they meet registry inclusion criteria and are not eligible for enrollment into the randomized study.","ALL","18 Years",{"count":1474,"type":1475},380,"ESTIMATED","INTERVENTIONAL",[1478],"NA","To demonstrate the safety and effectiveness of the Shockwave Reducer for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardial ischemia in the distribution of the left coronary artery and who are deemed unsuitable for revascularization. A non-randomized single-arm registry will further assess the safety and effectiveness of the Shockwave Reducer in selected subjects with reversible myocardial ischemia in the distribution of the right coronary artery and who are deemed unsuitable for revascularization, subjects without documented obstructive coronary disease and abnormal coronary flow reserve (ANOCA), and subjects who cannot complete an exercise tolerance test due to lower limb amputation (above the ankle) or other physiologic condition with documented chronic mobility or balance issues that require the use of a walking aid.",[1481],"Refractory Angina","2026-04-20",{"date":1484,"type":1485},"2026-04-22","ACTUAL",{"date":1487,"type":1485},"2022-01-04",{"date":1489,"type":1475},"2032-01",{"name":5,"class":6},95]