[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568773":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":31,"locations":30,"responsibleParty":37,"collaborators":30,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":30,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":30,"enrollmentInfo":49,"targetDuration":30,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":66,"whyStopped":30,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":30},{"fullName":5,"class":6},"St Vincent's University Hospital, Ireland","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Calcipotriol \u002F Dovonex","ACTIVE_COMPARATOR","Randomised to PDT pre-treatment with calcipotriol",[13,14],"Drug: 5-FU (fluorouracil)","Drug: Calcipotriol",{"label":16,"type":10,"description":17,"interventionNames":18},"Calcipotriol \u002FDovonex","Calcipotriol pre-treatment prior to PDT",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","5-FU (fluorouracil)","Topical 5-FU (fluorouracil) pretreatment prior to dovonex",[9,16],[26],"Efudix",{"type":21,"name":28,"description":17,"armGroupLabels":29,"otherNames":30},"Calcipotriol",[9,16],null,[32],{"name":33,"role":34,"phone":35,"phoneExt":30,"email":36},"Maeve Herlihy","CONTACT","012213297","maeveherlihy@svhg.ie",{"type":38,"investigatorFullName":33,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Dr Maeve Herlihy","100568773","efficacy-of-topical-5-fluorouracil-vs-calcipotriol-as-photodynamic-therapy-pre-treatment-for-field-actinic-keratoses-100568773",false,"NCT06685588","Efficacy of Topical 5-Fluorouracil Vs Calcipotriol As Photodynamic Therapy Pre-treatment for Field Actinic Keratoses","Efficacy of Topical 5-FUvs Calcipotriol As PDT Pre-treatment for Field Actinic Keratoses","Inclusion Criteria:\n\n* Adult (\\>18 years old)\n* Field actinic keratoses on scalp\n* Generally good health\n\nExclusion Criteria:\n\n* Immunosuppression\n* Unable to provide consent\n* Abnormal photosensitivity\n* Contact allergy to metvix \u002F 5-FU \u002F calcipotriol \u002F topical corticosteroids\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":50,"type":51},50,"ESTIMATED","INTERVENTIONAL",[54],"NA","The purpose of this study is to compare two different creams (5-fluorouracil, known as Efudix, and calcipotriol, known as Dovonex) to see which one works better when used before Photodynamic Therapy (PDT) to treat sun-damaged skin on the scalp (called actinic keratoses).\n\nPDT is often used on its own to treat these spots, but it doesn't always remove them completely. Using Efudix or Dovonex before PDT might improve the results, but we don't yet know which is better.\n\nThe main questions are -\n\n1. Is efudix or dovonex better at treating actinic keratoses when used prior to PDT\n2. Is efudix or dovonex more tolerable for patients?\n\nParticipants will be randomised to treat their scalp with efudix or dovonex for seven days prior to their first PDT treatment. They will be reviewed on day 7, prior to starting PDT, and again a week later when they present for their second PDT treatment.\n\nDuring follow up, patients will be reviewed at 28 days, 3, 6, 9, and 12 months after treatment.\n\nAt each of these visits, the number of actinic keratoses will be counted, graded, mapped and photographed to allow assessment of improvement before and after treatment.",[57,58],"Actinic Keratosis of Face and Scalp","Actinic Keratoses",[60,61,62,63,64,65],"efudix","dovonex","5-fluorouracil","calcipotriol","actinic keratosis","actinic keratoses","NOT_YET_RECRUITING","2024-11-10",{"date":69,"type":70},"2024-11-12","ACTUAL",{"date":72,"type":51},"2025-01",{"date":74,"type":51},"2026-01",{"name":5,"class":6}]