[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603092":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":44,"responsibleParty":63,"collaborators":67,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":11,"eligibilityCriteria":78,"healthyVolunteers":75,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":11,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":47,"whyStopped":11,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Universidade Federal de Pernambuco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active transcutaneous vagus nerve stimulation stimulation (taVNS)","EXPERIMENTAL",null,[13],"Device: Active taVNS",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham transcutaneous vagus nerve stimulation stimulation (s-tAVNS)","SHAM_COMPARATOR",[18],"Device: Sham taVNS",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Active taVNS","Protocol uses a 25 Hz frequency with 500 μs pulse width in biphasic configuration, operating at a 1:1 duty cycle with current intensity set to the maximum tolerable level without inducing pain. The total stimulation duration is 60 minutes. The stimulation is combined with physical therapy focused on upper extremity function.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Sham taVNS","Physical therapy focused on upper extremity function with masking for transcutaneous vagus nerve stimulation",[15],[30],{"name":31,"affiliation":5,"role":32},"Kátia Monte-Silva, PhD in Neurosciences","STUDY_DIRECTOR",[34,40],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"DANIEL G DE MELO, MsC","CONTACT","+5581995173332","+55","gmelodaniel@gmail.com",{"name":41,"role":36,"phone":42,"phoneExt":38,"email":43},"Gabriel Barreto, PhD","83996106134","gbarretoantonino@gmail.com",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Federal University of Pernambuco","RECRUITING","Recife","Pernambuco","50670-901","Brazil","BR",{"type":54,"coordinates":55},"Point",[56,57],-34.88111,-8.05389,{"lat":57,"lon":56},[60],{"name":35,"role":36,"phone":61,"phoneExt":62,"email":39},"81995173332","+ 55",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Kátia Monte-Silva","Professor",[68,70],{"name":69,"class":6},"Fundação de Amparo à Ciência e Tecnologia de Pernambuco",{"name":71,"class":72},"Conselho Nacional de Desenvolvimento Científico e Tecnológico","OTHER_GOV","100603092","efficacy-of-trans-auricular-vagus-nerve-stimulation-on-upper-extremity-motor-recovery-in-stroke-survivors-100603092",false,"NCT07132021","Efficacy of Trans-auricular Vagus Nerve Stimulation on Upper Extremity Motor Recovery in Stroke Survivors","Inclusion Criteria:\n\nPatients aged between 18 and 75 years, with motor impairment in the upper extremity caused by unilateral ischemic or hemorrhagic stroke with stroke onset within the last five years.\n\nExclusion Criteria:\n\n* Patients with any contraindication to taVNS, peripheral upper extremity injuries, use of medication affecting cortical excitability in the past 3 months, use of botulinum toxin in the past 3 months, presence of any other neurological disorder, or significant cognitive deficits.","ALL","18 Years","75 Years",{"count":83,"type":84},30,"ESTIMATED","INTERVENTIONAL",[87],"NA","The aim of this clinical trial is to determine if trans-auricular vagus nerve stimulation (taVNS) is effective in improving upper extremity function in stroke survivors. The primary objectives include: Investigating whether taVNS improves motor function in stroke survivors. The secondary objectives include: Assessing any potential side effects associated with the method. Investigating taVNS effects on daily routine functions and spasticity Researchers will conduct a comparative analysis between taVNS and a sham procedure (which mimics the stimulation without any actual effect) to assess its effectiveness. Participants in the trial will: Undergo taVNS combined with physical therapy or a sham procedure with physical therapy daily over a two-week period.",[90],"Stroke",[92,93,94],"trans-auricular vagus nerve stimulation","stroke","upper extremity function","2026-04-28",{"date":97,"type":98},"2026-05-04","ACTUAL",{"date":100,"type":98},"2025-08-01",{"date":102,"type":84},"2026-12-01",{"name":5,"class":6},1]