[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611069":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":25,"locations":36,"responsibleParty":51,"collaborators":24,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":24,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":79,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Microwave Ablation Treatment","EXPERIMENTAL","Patients with symptomatic uterine fibroids who meet inclusion criteria will undergo ultrasound-guided percutaneous microwave thermal ablation (PMTA). The procedure involves percutaneous insertion of a microwave needle (1.4 to 1.6mm diameter and 15 to 20 cm length) into the fibroid under US guidance, with thermal ablation continuing for 10 to 30 minutes under IV sedation. Patients will be followed at 3 and 6 months to assess fibroid size reduction and symptom improvement.",[13],"Procedure: Ultrasound-Guided Percutaneous Microwave Thermal Ablation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Ultrasound-Guided Percutaneous Microwave Thermal Ablation","Minimally invasive percutaneous microwave thermal ablation of symptomatic uterine fibroids performed under ultrasound guidance. After 8 hours fasting and under aseptic conditions with IV sedation, a microwave needle (1.4-1.6mm diameter, 15-20cm length depending on fibroid site and size) is inserted percutaneously into the fibroid under ultrasound guidance. Thermal ablation is performed for 10-30 minutes to achieve coagulation necrosis of the fibroid tissue. Patients are discharged after several hours with post-procedure antibiotics and analgesics. Follow-up assessments at 3 and 6 months include ultrasound imaging, hemoglobin levels, and symptom evaluation.",[9],[21,22,23],"PMTA","Microwave Ablation","MWA",null,[26,32],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Nagham N Omar, Professor","CONTACT","01028820041","20","Nagham.omar@aun.edu.eg",{"name":33,"role":28,"phone":34,"phoneExt":30,"email":35},"Jihad H Mahmoud, Doctorate","01097385666","Jihadhussien734@med.aun.edu.eg",[37],{"facility":5,"status":24,"city":38,"state":39,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Asyut","Assiut Governorate","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.18368,27.18096,{"lat":46,"lon":45},[49],{"name":33,"role":28,"phone":50,"phoneExt":30,"email":35},"+20 1097385666",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Jihad Hussien Mohamed Mahmoud","Specialist","100611069","efficacy-of-ultrasound-guided-microwave-ablation-in-the-treatment-of-uterine-fibroids-100611069",false,"NCT07235787","Efficacy of Ultrasound Guided Microwave Ablation in the Treatment of Uterine Fibroids.","MWAUF","Inclusion Criteria:\n\nFemale patients aged 25 years or older Good general health Symptomatic uterine fibroids suitable for microwave ablation as determined by examining gynecologist Premenopausal status Acceptable risks for general anesthesia or sedation Number of fibroids: fewer than 5 Size of fibroid: less than 10 cm\n\nExclusion Criteria:\n\nOngoing anticoagulant treatment and\u002For known bleeding disorder Chronic diseases contraindicating general anesthesia Pregnancy Postmenopausal status 5 or more fibroids Fibroid size 10 cm or larger Poor general health precluding anesthesia or sedation","FEMALE","25 Years",{"count":65,"type":66},20,"ESTIMATED","INTERVENTIONAL",[69],"NA","Uterine fibroids are the most common benign tumors of the female genital tract and can significantly affect the quality of life in reproductive-age women, causing symptoms such as heavy menstrual bleeding, pelvic pressure, urinary disturbances, dyspareunia, and infertility. Traditional surgical interventions such as myomectomy and hysterectomy remain the standard of care, yet they are associated with considerable trauma, longer recovery times, and the loss of uterine function.\n\nMicrowave ablation (MWA) is a minimally invasive image-guided technique that uses microwave energy to induce coagulative necrosis in fibroid tissue, reducing its size and alleviating symptoms while preserving the uterus. This study aims to evaluate the feasibility, safety, and therapeutic effectiveness of ultrasound-guided percutaneous microwave thermal ablation (PMTA) in the management of symptomatic uterine fibroids.\n\nEligible participants are premenopausal women aged 25 years or older with symptomatic fibroids less than 10 cm in size and fewer than five in number. Exclusion criteria include pregnancy, bleeding disorders, chronic diseases contraindicating anesthesia, and ongoing anticoagulant therapy.\n\nEach participant will undergo ultrasound-guided microwave ablation under aseptic conditions and sedation. Fibroid size, menstrual bleeding patterns, hemoglobin levels, and pain scores will be evaluated at baseline and during follow-up at 3 and 6 months. The primary outcome is the reduction in fibroid size, while secondary outcomes include symptom improvement and hemoglobin level changes.\n\nThis prospective case series will be conducted at Assiut University Hospitals, Egypt, with 20 participants referred from the Gynecology Department to the Interventional Radiology Unit. The results will provide valuable data on the clinical value of MWA as a uterus-preserving alternative for symptomatic uterine fibroids.",[72,73],"Uterine Fibroids (Leiomyoma)","Symptomatic Uterine Leiomyoma",[75,76,77,78],"Uterine fibroids","Leiomyoma","Microwave ablation (MWA)","Ultrasound-guided ablation","NOT_YET_RECRUITING","2025-11-16",{"date":82,"type":83},"2025-11-19","ACTUAL",{"date":85,"type":66},"2025-11-30",{"date":87,"type":66},"2027-12-01",{"name":53,"class":6},1]