[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572097":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":31,"responsibleParty":53,"collaborators":55,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":31,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":31,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":117,"whyStopped":31,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":31},{"fullName":5,"class":6},"Changhai Hospital","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"1L PEG + 50g Magnesium sulfate (Group A)","EXPERIMENTAL","Take 50g magnesium sulfate and 1L polyethylene glycol for bowel preparation before colonoscopy",[13],"Drug: 1L PEG + 50g magnesium sulfate",{"label":15,"type":16,"description":17,"interventionNames":18},"3L PEG alone (Group B)","ACTIVE_COMPARATOR","Take 3L polyethylene glycol for bowel preparation before colonoscopy",[19],"Drug: 3L PEG",{"label":21,"type":16,"description":22,"interventionNames":23},"4L PEG alone (Group C)","Take 4L polyethylene glycol for bowel preparation before colonoscopy",[24],"Drug: 4L PEG",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","1L PEG + 50g magnesium sulfate","Subjects in Group A will use a regimen combining magnesium sulfate and polyethylene glycol for preoperative bowel preparation and undergo colonoscopy. 1 litter of polyethylene glycol is taken at 8pm the day before the colonoscopy and 50 gram of magnesium sulfate is taken 4-6 hours before the colonoscopy, and then drink 2000 ml of water within 2 hours.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"3L PEG","Subjects in Group B will use a regimen with 3L polyethylene glycol for preoperative bowel preparation and undergo colonoscopy. The 3 liters of polyethylene glycol solution is taken in split dosing, with 1 liter taken at 8pm the day before the colonoscopy and 2 liters taken 4-6 hours before the colonoscopy.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"4L PEG","Subjects in Group C will use a regimen with 4L polyethylene glycol for preoperative bowel preparation and undergo colonoscopy. The 4 liters of polyethylene glycol solution is taken in split dosing, with 2 liters taken at 8pm the day before the colonoscopy and 2 liters taken 4-6 hours before the colonoscopy.",[21],[41],{"name":42,"affiliation":5,"role":43},"Zhaoshen Li, MD","PRINCIPAL_INVESTIGATOR",[45,49],{"name":42,"role":46,"phone":47,"phoneExt":31,"email":48},"CONTACT","86-021-31161365","li.zhaoshen@hotmall.com",{"name":50,"role":46,"phone":51,"phoneExt":31,"email":52},"Yu Bai, MD","86-021-31161335","baiyu1998@hotmail.com",{"type":54,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[56,58,60,62,64,67,70,72,74,76,78,80,82,84,86,88,90],{"name":57,"class":6},"The First Affiliated Hospital of Nanchang University",{"name":59,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":61,"class":6},"The Second Hospital of Hebei Medical University",{"name":63,"class":6},"Daping Hospital of Army Medical University",{"name":65,"class":66},"Ningjin People's Hospital","UNKNOWN",{"name":68,"class":69},"Zibo Central Hospital","OTHER_GOV",{"name":71,"class":6},"Zhengzhou Central Hospital",{"name":73,"class":6},"First Affiliated Hospital Xi'an Jiaotong University",{"name":75,"class":6},"Affiliated Yueqing Hospital of Wenzhou Medical University",{"name":77,"class":6},"Qianfoshan Hospital",{"name":79,"class":6},"The General Hospital of Western Theater Command",{"name":81,"class":6},"Jiangmen Central Hospital",{"name":83,"class":6},"The First Affiliated Hospital of Henan University of Science and Technology",{"name":85,"class":6},"LiuZhou People's Hospital",{"name":87,"class":6},"The Fifth Affiliated Hospital of Zunyi Medical College",{"name":89,"class":6},"Yan'an University Affiliated Hospital",{"name":91,"class":6},"900th Hospital of PLA Joint Logistic Support Force","100572097","efficacy-safety-and-tolerability-of-magnesium-sulfate-with-low-volume-polyethylene-glycol-for-colonoscopy-cleansing-100572097",false,"NCT06728839","Efficacy, Safety and Tolerability of Magnesium Sulfate With Low-volume Polyethylene Glycol for Colonoscopy Cleansing","Efficacy, Safety and Tolerability of Magnesium Sulfate With Low-volume Polyethylene Glycol for Bowel Preparation Before Colonoscopy: A Multicentre, Randomized, Controlled Trial","Inclusion Criteria:\n\n* 18-75 years old, male or female\n* To undergo screening, surveillance and diagnostic colonoscopy\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Subjects with therapeutic colonoscopy for colorectal polyps\n* Subjects with confirmed or suspected gastrointestinal obstruction, gastric retention, gastroparesis, gastric emptying disorder, or acute gastrointestinal bleeding\n* Subjects with confirmed or suspected colorectal cancer, inflammatory bowel disease, toxic colitis, or toxic megacolon\n* Subjects with renal or liver dysfunction, congestive heart failure or rhabdomyolysis\n* Subjects with ascites, suspected electrolyte abnormalities, or uncorrected dehydration\n* Subjects with constipation (\\\u003C3 times a week, difficult defecation, dry stool, less amount)\n* Subjects with serious cardiac and cerebrovascular diseases,suffering from metabolic disease or endocrine disease\n* Subjects who had previously undergone colorectal resection\n* Women with positive pregnancy tests or pregnancy plans, and women in lactation or allergic to the investigational drugs and their ingredients\n* Subjects who are participating in other clinical trials or receiving special drugs\n* Subjects with any other conditions that the investigator considered inappropriate for inclusion",true,"ALL","18 Years","75 Years",{"count":104,"type":105},1329,"ESTIMATED","INTERVENTIONAL",[108],"NA","Magnesium salts such as magnesium citrate are often combined with polyethylene glycol to make the intestinal preparation before colonoscopy, which has shown high cleaning efficacy. Magnesium sulfate combined with polyethylene glycol is less used in the world. This multicenter, randomized, controlled trial is aimed at to evaluate the efficacy and safety of magnesium sulfate combined with low-volume polyethylene glycol for preoperative bowel preparation for colonoscopy.",[111],"Bowel Preparation for Colonoscopy",[113,114,115,116],"Magnesium sulfate","colonoscopy","bowel preparation","adenoma detection rate","NOT_YET_RECRUITING","2024-12-08",{"date":120,"type":121},"2024-12-11","ACTUAL",{"date":123,"type":105},"2024-12-09",{"date":125,"type":105},"2025-08-31",{"name":5,"class":6}]