[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556392":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":50,"collaborators":26,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":26,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":26,"overallStatus":38,"whyStopped":26,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Tianjin Anding Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"dTMS group","EXPERIMENTAL","Participants receive active stimulation with H1 coil, consisting of 55 18 Hz, 2 s trains at 120% MT intensity, with a between-train interval of 20 s ,1980 pulses per day. The subjects were stimulated every day for 4 weeks (except weekends).",[13],"Device: deep Transcranial Magnetic Stimulation (dTMS) -active",{"label":15,"type":16,"description":17,"interventionNames":18},"sham group","SHAM_COMPARATOR","The sham stimulation was performed using the same procedures, with the sham coil.",[19],"Device: deep Transcranial Magnetic Stimulation (dTMS) -sham",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","deep Transcranial Magnetic Stimulation (dTMS) -active","with the H1-coil device included 20-min sessions of 18 Hz (2-s trains separated by 20-s inter-train intervals, 55 trains totaling 1980 pulses\u002Fsession).",[9],null,{"type":22,"name":28,"description":17,"armGroupLabels":29,"otherNames":26},"deep Transcranial Magnetic Stimulation (dTMS) -sham",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Jie Li, Doctor","CONTACT","+86 022 88188006","jieli@tjmhc.com",[37],{"facility":5,"status":38,"city":39,"state":26,"zip":26,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Tianjin","China","CN",{"type":43,"coordinates":44},"Point",[45,46],117.17667,39.14222,{"lat":46,"lon":45},[49],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},{"type":51,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100556392","efficacy-tolerability-and-cognitive-effects-of-deep-transcranial-magnetic-stimulation-for-bipolar-depression-100556392",false,"NCT06524505","Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression","Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression: a Double-blind, Randomized Controlled Trial","Inclusion Criteria:\n\nConfirmed diagnosis of bipolar depression;\n\n* age between 18 and 65 years;\n* a 17-item Hamilton Depression Rating Scale (HDRS-17) score \\>= 17,\n* a stable pharmacological regimen maintained for at least 4 weeks prior to the beginning of the treatment phase ;\n* for participants who had previously received antidepressant therapy, a minimum 4-week washout period followed by re-evaluation.\n\nExclusion Criteria:\n\n* a lifetime history of other psychiatric disorders, neurological diseases, or severe brain injury;\n* receipt of electroconvulsive therapy, rTMS, transcranial direct current stimulation, transcranial alternating current stimulation, or other neurostimulation treatments within the previous 3 months;\n* contraindications to magnetic stimulation, including epilepsy, cardiovascular disorders, or metallic implants in the head;\n* the presence of hypomanic\u002Fmanic symptoms at baseline or a score greater than 12 on the Young Mania Rating Scale (YMRS);\n* pregnancy or lactation.","ALL","18 Years","65 Years",{"count":63,"type":64},100,"ESTIMATED","INTERVENTIONAL",[67],"NA","The aim of this study is to evaluate the feasibility and efficacy of deep transcranial magnetic stimulation (dTMS) as an add-on treatment for bipolar depression. Meanwhile, we aim to evaluate the effect of dTMS on cognitive function of bipolar depressive patients. We hypothesize dTMS would improve depressive symptoms and cognitive function in bipolar disorder.",[70],"Bipolar Depression","2026-02-24",{"date":73,"type":74},"2026-02-27","ACTUAL",{"date":76,"type":74},"2024-08-01",{"date":78,"type":64},"2026-02",{"name":5,"class":6},1]