[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623864":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":34,"responsibleParty":61,"collaborators":20,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":20,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":87,"whyStopped":20,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"EIT-Guided Recruitment","EXPERIMENTAL","This arm includes all participants undergoing a standardized staircase lung recruitment maneuver under continuous monitoring with Electrical Impedance Tomography (EIT). EIT is used to assess regional ventilation distribution and guide the titration of PEEP. Mechanical ventilation settings are adjusted based on individual EIT-derived responses. Respiratory mechanics, including transpulmonary pressure and compliance partitioning, are also recorded to evaluate physiological effects of recruitment.",[13],"Device: Electrical Impedance Tomography (EIT)-Guided Lung Recruitment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Electrical Impedance Tomography (EIT)-Guided Lung Recruitment","Staircase Recruitment Maneuver",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Giovanna Chidini, MD","Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico","PRINCIPAL_INVESTIGATOR",[27,31],{"name":23,"role":28,"phone":29,"phoneExt":20,"email":30},"CONTACT","0039-2-55032242","giovanna.chidini@policlinico.mi.it",{"name":32,"role":28,"phone":29,"phoneExt":20,"email":33},"Stefano Scalia Catenacci, MD","stefano.scaliacatenacci@policlinico.mi.it",[35,55],{"facility":24,"status":20,"city":36,"state":37,"zip":38,"country":37,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Milan","Italy","20100","IT",{"type":41,"coordinates":42},"Point",[43,44],12.59836,42.78235,{"lat":44,"lon":43},[47,50,54],{"name":48,"role":28,"phone":29,"phoneExt":20,"email":49},"Virginia Figgiaconi, MD","virginia.figggiaconi@policlinico.mi.it",{"name":51,"role":28,"phone":52,"phoneExt":20,"email":53},"Mario Madeo, Senior Nurse","0039-2-55032241","mario.madeo@policlinico.mi.it",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"facility":56,"status":20,"city":36,"state":20,"zip":57,"country":37,"countryCode":39,"cosmosGeoPoint":58,"geoPoint":60,"contacts":20},"Fondazione Irccs Cà Granda Ospedale Maggiore Policlinico","20122",{"type":41,"coordinates":59},[43,44],{"lat":44,"lon":43},{"type":25,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Giovanna Chidini","Principal Investigator","100623864","eit--guided-lung-recruitment-in-pards-100623864",false,"NCT07402174","EIT- Guided Lung Recruitment in pARDS","EIT- Guided Lung Recruitment in Pediatric Acute Respiratory Distress Syndrome","REMAV-EIT","Inclusion Criteria:\n\n* Children aged between 1 month and 10 years\n* Diagnosis of pediatric Acute Respiratory Distress Syndrome (pARDS) according to PALICC-2 criteria\n* Invasive mechanical ventilation for less than 48 hours at the time of enrollment\n\nExclusion Criteria:\n\n* Evidence or history of barotrauma (e.g., pneumothorax, pneumomediastinum)\n* Presence of congenital heart disease with hemodynamic significance\n* Known or suspected intracranial hypertension\n* Presence of an implantable cardioverter-defibrillator (ICD)\n* Parental o legal guardian refuse","ALL","1 Month","10 Years",{"count":76,"type":77},8,"ESTIMATED","INTERVENTIONAL",[80],"NA","Study Title:\n\nEIT-Guided Lung Recruitment Maneuvers in Pediatric ARDS: Effects on Ventilation Distribution and Respiratory Mechanics\n\nStudy Objective:\n\nThe primary goal of this clinical trial is to determine whether lung recruitment maneuvers guided by Electrical Impedance Tomography (EIT) result in a more homogeneous ventilation distribution and less injurious ventilation in children with pediatric Acute Respiratory Distress Syndrome (pARDS). The study will assess changes in intrapulmonary gas distribution and respiratory mechanics during recruitment maneuvers using both EIT and partitioned respiratory mechanics.\n\nThis is a prospective cohort study involving children diagnosed with pARDS. Eligible participants will be consecutively enrolled over time and will undergo a standardized series of staircase lung recruitment maneuvers under continuous EIT monitoring. The final mechanical ventilation (MV) settings will be individualized and titrated based on the EIT-derived response to recruitment.\n\nMain Research Questions:\n\nHow can lung recruitment maneuvers be performed safely in children with pARDS? How can we monitor the physiological effects of recruitment on respiratory mechanics? How does recruitment influence the distribution of ventilation within the lungs?\n\nEligible participants will undergo a series of staircase lung recruitment maneuvers under continuous EIT monitoring. The final mechanical ventilation (MV) settings will be titrated and individualized based on the EIT-derived response to recruitment.",[83],"Acute Respiratory Distress Syndrome",[83,85,86],"EIT","Children","NOT_YET_RECRUITING","2026-02-03",{"date":90,"type":91},"2026-02-11","ACTUAL",{"date":93,"type":77},"2026-03-01",{"date":95,"type":77},"2027-06-01",{"name":5,"class":6},2]