[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606051":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":44,"responsibleParty":109,"collaborators":112,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":119,"sex":125,"minAge":126,"maxAge":26,"enrollmentInfo":127,"targetDuration":26,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":138,"overallStatus":87,"whyStopped":26,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":155},{"fullName":5,"class":6},"Pest County Flór Ferenc Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EIT-GROUP","EXPERIMENTAL","EIT-guided PEEP titration procedure to achieve individually optimal level of PEEP",[13],"Procedure: EIT-guided PEEP titration",{"label":15,"type":16,"description":17,"interventionNames":18},"Cdyn-GROUP","ACTIVE_COMPARATOR","Cdyn-guided PEEP titration procedure to achieve individually optimal level of PEEP",[19],"Procedure: Cdyn-guided PEEP titration",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","EIT-guided PEEP titration","During the PEEP titration procedure, PEEP will be decreased from 18 cmH2O by 2 cmH2O every 20 ventilatory cycles, until a final PEEP of 6 cmH2O.\n\nOn each level of PEEP EIT parameters and Cdyn values will be recorded in both groups.\n\nIn the EIT-GROUP optimal PEEP is considered as the intersect between the lower percentage of overdistension and collapse, based on the diagnostic tool of the EIT device.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Cdyn-guided PEEP titration","During the PEEP titration procedure, PEEP will be decreased from 18 cmH2O by 2 cmH2O every 20 ventilatory cycles, until a final PEEP of 6 cmH2O. On each level of PEEP EIT parameters and Cdyn values will be recorded in both groups.\n\nIn the Cdyn-GROUP optimal PEEP is considered as the PEEP value resulting the highest possible Cdyn measured by the ventilator.",[15],[32],{"name":33,"affiliation":34,"role":35},"Zoltán Ruszkai, MD, PhD","Flór Ferenc Hospital Kistarcsa","STUDY_DIRECTOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","36-20-915-1978","ruszkai.zoltan@florhosp.hu",{"name":42,"role":38,"phone":26,"phoneExt":26,"email":43},"Gergely Bokrétás, MD","bokretas.gregely@florhosp.hu",[45,68,86],{"facility":46,"status":47,"city":48,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Semmelweis University","NOT_YET_RECRUITING","Budapest","1085","Hungary","HU",{"type":53,"coordinates":54},"Point",[55,56],19.04045,47.49835,{"lat":56,"lon":55},[59,63,65],{"name":60,"role":38,"phone":61,"phoneExt":26,"email":62},"Zsolt Molnár, MD, PhD","+36 30 302 6668","molnar.zsolt1@semmelweis.hu",{"name":60,"role":64,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":66,"role":67,"phone":26,"phoneExt":26,"email":26},"Csenge Szigetváry, MD","SUB_INVESTIGATOR",{"facility":69,"status":47,"city":70,"state":71,"zip":72,"country":50,"countryCode":51,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Semmelweis Hospital Kiskunhalas","Kiskunhalas","Bács-Kiskun county","6400",{"type":53,"coordinates":74},[75,76],19.48479,46.43402,{"lat":76,"lon":75},[79,83,84],{"name":80,"role":38,"phone":81,"phoneExt":26,"email":82},"András Lovas, MD, PhD","+36 20 465 8580","anlovas@gmail.com",{"name":80,"role":64,"phone":26,"phoneExt":26,"email":26},{"name":85,"role":67,"phone":26,"phoneExt":26,"email":26},"Robin Forgács, MD",{"facility":34,"status":87,"city":88,"state":89,"zip":90,"country":50,"countryCode":51,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"RECRUITING","Kistarcsa","Pest County","2143",{"type":53,"coordinates":92},[93,94],19.26247,47.54757,{"lat":94,"lon":93},[97,99,101,102,104,106,107],{"name":33,"role":38,"phone":98,"phoneExt":26,"email":40},"+36 20 915 1978",{"name":42,"role":38,"phone":26,"phoneExt":26,"email":100},"bokretas.gergely@florhosp.hu",{"name":33,"role":64,"phone":26,"phoneExt":26,"email":26},{"name":103,"role":67,"phone":26,"phoneExt":26,"email":26},"Csanád Geréd, MD",{"name":105,"role":67,"phone":26,"phoneExt":26,"email":26},"Angéla Mikó, MD",{"name":42,"role":67,"phone":26,"phoneExt":26,"email":26},{"name":108,"role":67,"phone":26,"phoneExt":26,"email":26},"Tamás Fekete, MD",{"type":64,"investigatorFullName":110,"investigatorTitle":111,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Zoltan Ruszkai, MD, PhD","Head of Department of Anesthesiology and Intensive Therapy",[113,116],{"name":114,"class":115},"Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged","OTHER_GOV",{"name":46,"class":6},"100606051","eit-vs-dynamic-compliance-guided-peep-titration-during-laparoscopic-gynecological-surgery-100606051",false,"NCT07170514","EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery","Electrical Impedance Tomography vs Dynamic Compliance Guided Positive End-expiratory Pressure Titration During Laparoscopic Gynecological Surgery: A Multi-center, Prospective Randomized Trial - TITRANT","TITRANT","Inclusion criteria:\n\n* Patient scheduled for elective laparoscopic gynaecological surgery\n* Age \\> 18 years\n* Signed consent to participate in the trial\n\nExclusion criteria:\n\n* Age \\\u003C 18 years\n* American Society of Anesthesiologists (ASA) physical status IV\n* History of severe restrictive or chronic obstructive pulmonary disease (COPD, Global Initiative for Chronic Obstructive Lung Disease grades III or IV)\n* Uncontrolled bronchial asthma\n* Pulmonary metastases\n* History of any thoracic surgery\n* Need for thoracic drainage before surgery\n* Congestive heart failure (NYHA grades III or IV)\n* Extreme obesity (BMI\\>35 kg m-2)\n* Lack of patient's consent","FEMALE","18 Years",{"count":128,"type":129},200,"ESTIMATED","INTERVENTIONAL",[132],"NA","The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing laparoscopic gynecological surgery.\n\nDespite dynamic pulmonary compliance (Cdyn) guided lung protective ventilation has several proven advantages, the investigators hypothesize that optimizing intraoperative mechanical ventilation using electrical impedance tomography (EIT) may further improve patient outcomes, enhance postoperative recovery, shorten in-hospital stay and reduce healthcare related costs.\n\nThe main questions aim to answer are:\n\n* May EIT-guided PEEP titration reduce the mechanical power of ventilation and improve oxygenation more significantly than the Cdyn-guided method?\n* What effect might a decrease in mechanical power of ventilation have on postoperative pulmonary complications?\n\nParticipants will:\n\n* Receive an EIT-guided or a Cdyn-guided PEEP titration procedure during laparoscopic gynecological surgery.\n* Be assessed for mechanical power of ventilation, oxygenation, atelectasis and postoperative pulmonary complications during and 2 days after surgery.\n* Be followed-up for mortality until the 28th postoperative day.",[135,136,137],"Mechanical Power","Postoperative Pulmonary Complications (PPCs)","Oxygenation",[139,140,141,142,143,144,145],"electrical impedance tomography","dynamic pulmonary compliance","positive end-expiratory pressure","mechanical power","pulmonary protective ventilation","Pao\u002FFiO2","postoperative pulmonary complications","2026-04-09",{"date":148,"type":149},"2026-04-14","ACTUAL",{"date":151,"type":149},"2025-11-10",{"date":153,"type":129},"2027-10-30",{"name":5,"class":6},3]