[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549941":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":36,"locations":10,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":67,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I",null,"Age and sex matched healthy Control",[13],"Diagnostic Test: PCR",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2","50 patients with β-thalassemia major",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group 3","50 patients with β-thalassemia intermedia",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","PCR","Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for detection of EKLF:\n\n* The method of total RNA extraction: TRIZOL and TRIZOL LS.\n* The purity and concentration of the RNA will be measured using Nano Drop 2000 instument.\n* cDNA will be done with primers using thr Goscript Reverse Transcription System",[15,19,9],[29,32,34],{"name":30,"affiliation":5,"role":31},"Eman Naser Eldin","STUDY_DIRECTOR",{"name":33,"affiliation":5,"role":31},"Sherif Helmy",{"name":35,"affiliation":5,"role":31},"Reem Elagoz",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Rofida Hassan","CONTACT","+2 1019935111","mahaseb_rofaida@yahoo.com",{"name":30,"role":39,"phone":43,"phoneExt":10,"email":44},"01002677890","emannasr2000@yahoo.com",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Rofaida Hassan Ahmed","Principle investigator","100549941","eklf-gene-expression-in--thalassemia-100549941",false,"NCT06440603","EKLF Gene Expression in β-thalassemia","Erythroid Krüppel Like Factor (EKLF) Gene Expression in β-thalassemia Patients","Inclusion Criteria:\n\n* patients with β-thalassemia (major and intermedia).\n* patients are of both sexes (male or female) at any age\n\nExclusion Criteria:\n\n* patients with any other types of hemolytic anaemia",true,"ALL","5 Years","80 Years",{"count":61,"type":62},150,"ESTIMATED","OBSERVATIONAL","1. Studying the effect of expression pattern of EKLF gene in β-thalassemic patients.\n2. Detecting the correlation between the gene expression of EKLF and the clinical phenotype of β-thalassemic patients.",[66],"β-thalassemia","NOT_YET_RECRUITING","2024-05-31",{"date":70,"type":71},"2024-06-04","ACTUAL",{"date":73,"type":62},"2024-07-01",{"date":75,"type":62},"2027-07-01",{"name":47,"class":6}]