[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536700":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":60,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":25,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Electro-acupuncture group","EXPERIMENTAL","Patients in EA group receive acupuncture at Shuigou (also known as Renzhong, GV26) and Yintang (updated number GV24+, previous number GV29). Paired electrodes from the EA apparatus are clipped to the needle handles at Shuigou and Yintang. The electroacupuncture stimulation lasts for 30 minutes with a wave of rarefaction and condensation (10 Hz \u002F 50 Hz) and a current intensity of the maximum withstand current within 7mA. All patients receive EA at 9 am for 30 minutes once a day for consecutive 14 days.",[13],"Other: Electroacupuncture",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham electro-acupuncture group","SHAM_COMPARATOR","Patients in sham-EA group receive sham-EA at sham-Shuigou and sham-Yintang.Acupuncture needles are inserted into the adhesive pads but do not pierce the skin. Paired electrodes from the EA apparatus via sham connecting cords are clipped to the needle handles at sham-Shuigou and sham-Yintang. The sham connecting cords are similar in appearance to the normal ones, but the inner wires in sham connecting cords are cut off and cannot conduct electricity. All patients receive sham-EA at 9 am for 30 minutes once a day for consecutive 14 days.",[19],"Other: Sham electroacupuncture",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Electroacupuncture","Electro-acupuncture at Shuigou and Yintang.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sham electroacupuncture","Sham-EA at sham-Shuigou and sham-Yintang.",[15],[31],{"name":32,"affiliation":33,"role":34},"Fang Yuan, PhD","The Second Affiliated Hospital of Guangzhou University of Chinese Medicine","STUDY_DIRECTOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+86-20-81887233","yuanfang@gzucm.edu.cn",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Jixiang Chen, PhD","756337176@qq.com",[44],{"facility":33,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Guangzhou","Guangdong","510120","China","CN",{"type":52,"coordinates":53},"Point",[54,55],113.25,23.11667,{"lat":55,"lon":54},[58],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":59},"plawlx@gzucm.edu.cn",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Fang Yuan","Principal Investigator","100536700","electro-acupuncture-to-treat-disorder-of-consciousness-100536700",false,"NCT06268236","Electro-acupuncture to Treat Disorder of Consciousness","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. With cerebral damage due to TBI；\n3. Diagnosed with UWS or MCS based on at least two CRS-R assessments;\n4. From 4 to 16 weeks from the onset of brain injury;\n5. Informed consent obtained.\n\nExclusion Criteria:\n\n1. With a history of neurological or psychiatric disorder prior to the brain injury;\n2. With uncontrolled seizures or status epilepticus;\n3. Unstable vital signs and requiring the use of vasoactive agents;\n4. With the use of general anesthetics or central acting sedative;\n5. Without intact skin at acupoints or sham points;\n6. Concomitant medical illness that would interfere with the outcome assessments and\u002For follow-up\n7. Pregnant patients;\n8. Currently participating in other investigational trials;\n9. High likelihood of not adhering to the study treatment or the follow-up regimen",true,"ALL","18 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"NA","With the rapid development of life support technology, more and more people can survive severe brain injury. Some survivors regain consciousness after a period of coma, however, many patients develop prolonged disorders of consciousness (DOC), which poses a therapeutic challenge for clinicians and a heavy burden for their families. The investigators design an Electro-acupuncture to treat disorder of consciousness (AcuDoc) trial with the aim of validating the clinical effect of electroacupuncture in treating DOC and exploring its therapeutic mechanisms by integrating EEG, neuroimaging, evoked potential tests, and behavioral assessments.",[81,22],"Disorder of Consciousness",[83,84,85,86,87],"Acute brain injury","Disorder of consciousness","Electro-acupuncture","Awakening","Brain functional network","2024-09-12",{"date":90,"type":91},"2024-09-19","ACTUAL",{"date":93,"type":91},"2024-01-01",{"date":95,"type":75},"2026-01-31",{"name":5,"class":6},1]