[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623131":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":42,"locations":32,"responsibleParty":48,"collaborators":32,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":32,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":32,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":75,"whyStopped":32,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":32},{"fullName":5,"class":6},"First People's Hospital of Hangzhou","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroacupuncture (EA) Group","EXPERIMENTAL","Paroxetine Hydrochloride Tablets + Electroacupuncture",[13,14],"Procedure: Electroacupuncture (EA)","Drug: Routine Medication",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham Electroacupuncture (SEA) Group","SHAM_COMPARATOR","Paroxetine Hydrochloride Tablets + Sham Electroacupuncture",[20,14],"Procedure: Sham Electroacupuncture (SEA)",{"label":22,"type":23,"description":24,"interventionNames":25},"Waiting-list (WL) Group","ACTIVE_COMPARATOR","Paroxetine Hydrochloride Tablets + Delayed EA Treatment",[14],[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","Electroacupuncture (EA)","Electroacupuncture (EA) is performed at acupoints including GV20 (Baihui), EX-HN1 (Sishencong), GV29 (Shenting), EX-HN16 (Anmian, bilateral), HT7 (Shenmen, bilateral), PC6 (Neiguan, bilateral), CV6 (Qihai), CV4 (Guanyuan), ST36 (Zusanli, bilateral), SP6 (Sanyinjiao, bilateral), and LR3 (Taichong, bilateral). Sterile disposable needles (φ0.18×25mm or φ0.25×40mm) are used. Electric stimulation (continuous wave, 100Hz) is applied to specific point pairs (e.g., left Sishencong + anterior Sishencong) for 30 minutes. The current intensity is adjusted to the patient's maximum tolerance. Treatment is administered 3 times per week for 4 weeks (12 sessions total).",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Sham Electroacupuncture (SEA)","Sham electroacupuncture (SEA) is performed by inserting needles into non-acupoints located 5-10 mm away from the real points used in the EA group. Shallow needling (depth of 1-2 mm) is applied. A sham EA device with a disconnected electrode lead is used; although the screen displays parameters identical to the EA group, there is no actual current output. The duration, frequency, and total number of sessions are identical to the EA group (3 times\u002Fweek for 4 weeks).",[16],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"DRUG","Routine Medication","All groups receive Paroxetine Hydrochloride Tablets (20 mg\u002Ftablet). The initial dose is 20 mg once daily, taken orally. The daily dose may be increased in increments of 10 mg based on the patient's condition, with a minimum interval of 1 week between adjustments. The maximum daily dose is 50 mg.",[9,16,22],[43],{"name":44,"role":45,"phone":46,"phoneExt":32,"email":47},"Lishu Gao","CONTACT","+86 13858015836","rodelo@sina.com",{"type":49,"investigatorFullName":44,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"SPONSOR_INVESTIGATOR","Associate Chief Physician","100623131","electroacupuncture-for-generalized-anxiety-disorder-clinical-efficacy-and-neuroimaging-mechanisms-100623131",false,"NCT07392645","Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms","Clinical Efficacy of Electroacupuncture for Generalized Anxiety Disorder and Its Central Mechanism Based on Neuroimaging Changes","Inclusion Criteria:\n\n* Meet the DSM-5 diagnostic criteria for Generalized Anxiety Disorder (GAD).\n* No antidepressant or anti-anxiety medication in the past 2 weeks.\n* HAMA score ≥ 14.\n* Right-handed（for MRI).\n* Aged 18-60 years, with at least primary school education.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Complicated with severe cardiovascular, cerebrovascular, or organic diseases.\n* History of other psychiatric disorders (e.g., schizophrenia, bipolar disorder).\n* Contraindications for MRI (e.g., metal implants, claustrophobia).\n* Pregnancy or lactation.",true,"ALL","18 Years","60 Years",{"count":63,"type":64},123,"ESTIMATED","INTERVENTIONAL",[67],"NA","This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) in treating Generalized Anxiety Disorder (GAD). Participants will be randomly assigned to an EA group, a sham EA group, or a waiting-list control group. All participants will continue their routine medication (Paroxetine). The primary goal is to observe the reduction in anxiety symptoms using the Hamilton Anxiety Scale (HAMA). Additionally, the study will use functional MRI (fMRI) and Magnetic Resonance Spectroscopy (MRS) to explore the brain mechanisms through which EA helps alleviate anxiety.",[70],"Generalized Anxiety Disorder",[72,70,73,74],"Electroacupuncture","fMRI","Clinical Efficacy","NOT_YET_RECRUITING","2026-02-05",{"date":78,"type":79},"2026-02-06","ACTUAL",{"date":81,"type":64},"2026-02-01",{"date":83,"type":64},"2027-12-31",{"name":44,"class":6}]