[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630689":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":32,"centralContacts":36,"locations":44,"responsibleParty":94,"collaborators":23,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":99,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":23,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":23,"overallStatus":118,"whyStopped":23,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroacupuncture Group","EXPERIMENTAL","The electroacupuncture protocol follows a standardized framework consisting of a core acupoint formula combined with individualized local points. The core formula includes GV26 (Shuigou), LI4 (Hegu), PC6 (Neiguan), ST36 (Zusanli), GB34 (Yanglingquan), LR3 (Taichong), and SP6 (Sanyinjiao). For the individualized component, 1 to 4 additional acupoints are selected based on the two most severely affected joint areas.\n\nAcupuncture frequency: Acupuncture is performed twice a week, 30 minutes each time, for 8 weeks, totaling 16 sessions.",[13],"Procedure: Electroacupuncture Group",{"label":15,"type":10,"description":16,"interventionNames":17},"Auricular Acupressure Group","Auricular point sticking prescription: Basic auricular points combined with the corresponding auricular points of the affected joints.\n\nAuricular point frequency: Twice a week, the sticker is removed after 2 days and reapplied the next day, for 8 weeks, totaling 16 sessions.",[18],"Procedure: Auricular Acupressure Group",{"label":20,"type":21,"description":22,"interventionNames":23},"Waitlist Control Group","NO_INTERVENTION","After random grouping, only the basic treatment plan is adopted, and no acupoint stimulation therapy is received within 16 weeks.",null,[25,29],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":23},"PROCEDURE","Electroacupuncture is performed using the basic prescription combined with the prescription for the affected joints. Basic prescription: Shuigou (GV26), Hegu (LI4), Neiguan (PC6), Zusanli (ST36), Yanglingquan (GB34), Taichong (LR3), Sanyinjiao (SP6). On this basis, 1 to 4 additional acupoints are selected based on the two most severely affected joint areas.\n\nNeedle selection: The acupuncture needles (40 or 75 mm x 0.25 mm gauge, and 40 mm x 0.18 mm gauge, Huatuo, Suzhou, China) will be used.\n\nAn electroacupuncture stimulator (SDZ-V, Huatuo, Suzhou, China) will be used, delivering alternating frequencies of 2 Hz\u002F10 Hz with no more than four electrode pairs simultaneously.",[9],{"type":26,"name":15,"description":30,"armGroupLabels":31,"otherNames":23},"The auricular acupressure protocol is formed by combining the basic auricular point prescription and the auricular point prescription corresponding to the affected joints. The basic points include Shenmen, Sympathetic, Endocrine, and Subcortex, while the additional points are selected by the acupuncturist based on the 1-2 joint regions with the most pain as reported by the patient. Once identified, Vaccaria seed (Zhongyan Taihe, Beijing, China) is taped onto the points until the patient perceives a distinct sensation of soreness or tenderness. Participants will be instructed to apply pressure to each ear three times per day, pressing each side for approximately 3 minutes per session. The auricular patches will be removed 2 to 4 days after during a follow-up visit at the clinic.",[15],[33],{"name":34,"affiliation":5,"role":35},"Li Li","STUDY_CHAIR",[37,41],{"name":34,"role":38,"phone":39,"phoneExt":23,"email":40},"CONTACT","86+18222626653","lilitcm@foxmail.com",{"name":42,"role":38,"phone":23,"phoneExt":23,"email":43},"Jing Xue","xuejing506@163.com",[45,61,71,84],{"facility":46,"status":23,"city":47,"state":23,"zip":23,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital","Tianjin","China","CN",{"type":51,"coordinates":52},"Point",[53,54],117.17667,39.14222,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":23,"email":60},"Hailong Wang","86+13021368172","13021368172@163.com",{"facility":62,"status":23,"city":47,"state":23,"zip":23,"country":48,"countryCode":49,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"Tianjin Medical University Cancer Institute & Hospital",{"type":51,"coordinates":64},[53,54],{"lat":54,"lon":53},[67],{"name":68,"role":38,"phone":69,"phoneExt":23,"email":70},"bin Wang","86+13820156627","wbin8888@163.com",{"facility":72,"status":23,"city":73,"state":23,"zip":23,"country":48,"countryCode":49,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Affiliated Hospital of Qinghai University","Xining",{"type":51,"coordinates":75},[76,77],101.75739,36.62554,{"lat":77,"lon":76},[80],{"name":81,"role":38,"phone":82,"phoneExt":23,"email":83},"Miaozhou Wang","86+18609780037","wangmiaozhou@163.com",{"facility":85,"status":23,"city":73,"state":23,"zip":23,"country":48,"countryCode":49,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"Qinghai Provincial Hospital of Traditional Chinese Medicine",{"type":51,"coordinates":87},[76,77],{"lat":77,"lon":76},[90],{"name":91,"role":38,"phone":92,"phoneExt":23,"email":93},"Xiumei Feng","86+19282247274","332908772@qq.com",{"type":95,"investigatorFullName":34,"investigatorTitle":96,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Head of Breast Cancer Endocrine Therapy-Related Joint Pain Research","100630689","electroacupuncture-vs-auricular-acupressure-vs-waitlist-control-for-breast-cancer-endocrine-therapy-related-joint-pain-100630689",false,"NCT07490938","Electroacupuncture vs. Auricular Acupressure vs. Waitlist Control for Breast Cancer Endocrine Therapy-Related Joint Pain","Electroacupuncture Versus Auricular Acupressure Versus WaitliSt Control for Endocrine Therapy-related Joint Pain in Patients With Breast Cancer (EASE): A Pragmatic Multicenter Randomised Controlled Trial","EASE","Inclusion Criteria:\n\n* Histologically or cytologically confirmed breast cancer, stage I-IV, according to the AJCC Cancer Staging Manual (8th edition);\n* Aged 18-75 years;\n* Experiencing joint pain attributed to endocrine therapy, including localized or generalized joint pain, with symptoms persisting for at least 1 week;\n* Completion of all planned surgeries, chemotherapy, and radiotherapy, with a scheduled continuation of endocrine therapy for at least 1 additional year;\n* Self-reported worst joint pain score of ≥3 on a 0-10 Visual Analogue Scale (VAS) during the past week;\n* Life expectancy ≥1 year;\n* Voluntarily sign the informed consent.\n\nExclusion Criteria:\n\n* Bone metastases involving the same site as the affected joint attributed to endocrine therapy;\n* History of fracture or surgery involving the affected joints within the past 6 months;\n* Implanted electronic medical devices;\n* Not suitable for acupuncture, including but not limited to bleeding tendencies (e.g. coagulation disorders or purpura) or local skin lesions at the intended acupoint sites.","FEMALE","18 Years","75 Years",{"count":109,"type":110},200,"ESTIMATED","INTERVENTIONAL",[113],"NA","The purpose of this pragmatic, multicenter, randomized controlled trial is to evaluate the clinical effectiveness and safety of electroacupuncture and auricular acupressure for improving joint pain related to endocrine therapy in breast cancer patients. A total of 200 participants will be recruited and randomly assigned to one of three groups: the Electroacupuncture Group (n=80), the Auricular Acupressure Group (n=80), or the Waitlist Control Group (n=40), using a central stratified block randomization method.\n\nThe primary objective is to compare changes in Worst Pain Item score among the three groups from baseline to the end of the treatment period, as measured by the Brief Pain Inventory-Short Form (BPI-SF). Secondary objectives include assessing pain interference, overall health status through the PROMIS scale, and quality of life specifically related to endocrine therapy using the FACT-ES. Additionally, the study will evaluate analgesic medication use (QAQ), patient expectations (Acupuncture Expectancy Scale), treatment adherence, and the occurrence of adverse events. By comparing these interventions, this study aims to generate high-quality evidence for the management of treatment-related arthralgia in breast cancer survivors.",[116,117],"Breast Cancer Survivors","Endocrine Therapy-Induced Joint Pain","NOT_YET_RECRUITING","2026-03-31",{"date":121,"type":122},"2026-04-06","ACTUAL",{"date":124,"type":110},"2026-04",{"date":126,"type":110},"2027-12",{"name":5,"class":6},4]