[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547579":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":11,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":11,"enrollmentInfo":54,"targetDuration":11,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":28,"whyStopped":11,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"University College, London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention arm","EXPERIMENTAL",null,[13],"Other: ECOG Array",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":11},"ECOG Array","The patient will undergo their intracranial neurosurgical procedure as planned, using conventional brain retractors and neurosurgical equipment.\n\nStandard neuromonitoring (EEG, MEP, SSEP) will be placed after the induction of neuroanaesthesia if indicated. Additional to whatever conventional EMBRI neuromonitoring is used, intraoperatively an ECoG array will be positioned under the retractor by the operating surgeon. Further electrode arrays may be placed on the cortical surface remote from the retractor as needed to establish a reference.\n\nTypically we anticipate one ECoG array under the retractor blade with a reference array on an area of unretracted brain.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Siddharth Sinha","CONTACT","004420 3456 7890","siddharth.sinha@ucl.ac.uk",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"National Hospital Neurology and Neurosurgery","RECRUITING","London","Greater London","WC1N 3BG","United Kingdom","UK",{"type":35,"coordinates":36},"Point",[37,38],-0.12574,51.50853,{"lat":38,"lon":37},[41],{"name":21,"role":22,"phone":11,"phoneExt":11,"email":24},{"type":43,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100547579","electrocorticographic-monitoring-of-brain-retraction-injury-embri-100547579",false,"NCT06409806","Electrocorticographic Monitoring of Brain Retraction Injury (EMBRI)","Electrocorticography As a Neurophysiological Marker for Intraoperative Monitoring for Brain Retraction: an IDEAL Stage 1 Study","EMBRI","Inclusion Criteria:\n\n* Patients aged 16 or older undergoing intracranial surgery where it is anticipated fixed brain retraction will be used.\n\nExclusion Criteria:\n\n* Patients without capacity to give consent at time of recruitment","ALL","16 Years",{"count":55,"type":56},6,"ESTIMATED","INTERVENTIONAL",[59],"NA","A single centre IDEAL Stage 1 feasibility study using novel electrophysiological recording techniques in adult participants undergoing neurosurgery. This is a first in human study, building upon previous preclinical mice experiments.\n\nParticipants will undergo their planned neurosurgical procedure as normal. In addition to their standard treatment neurophysiological monitoring including an electrocorticography electrode placed on the brain deep to the retractor will be used to monitor for signs of brain retraction injury.",[62,63,64],"Brain Injury","Neurosurgery","Brain Ischemia",[66],"Brain retraction","2024-09-17",{"date":69,"type":70},"2024-09-19","ACTUAL",{"date":72,"type":70},"2022-08-01",{"date":74,"type":56},"2026-03-01",{"name":5,"class":6},1]