[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600251":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":54,"collaborators":20,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":20,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":35,"whyStopped":20,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"IRCCS Eugenio Medea","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with Friedreich's ataxia undergoing HD-EEG and neurofunctional rehabilitation.","EXPERIMENTAL","This arm includes patients with a confirmed genetic diagnosis of Friedreich's Ataxia (FRDA), aged between 8 and 60 years, with SARA scale scores below 30. Participants undergo high-density electroencephalogram (HD-EEG) recording under resting conditions and during a motor task, as well as a comprehensive neuropsychological and emotional assessment. All follow an intensive rehabilitation program lasting 3-4 weeks. HD-EEG recordings are repeated after treatment and one year later to assess longitudinal changes in functional connectivity and identify potential biomarkers associated with clinical progression.",[13],"Device: HD-EEG recordings, combined with cognitive and motor assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","HD-EEG recordings, combined with cognitive and motor assessment","Participants will undergo high-density EEG (HD-EEG) recordings under two conditions: at rest and while performing an upper limb motor task. The data obtained will be used to reconstruct source cortical activity and derive patterns of functional connectivity, using advanced neurophysiological analysis techniques, including the Avalanche Transition Matrix (ATM). In addition, patients will complete a neuropsychological assessment and participate in an intensive multidisciplinary rehabilitation program lasting 3 to 4 weeks, depending on age. The intervention aims to assess changes in the functional organization of the brain before and after treatment, as well as one year later, in order to explore potential biomarkers of disease progression.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Gabriella Paparella, Medical Doctor","IRCCS E. Medea \u002F Associazione la Nostra Famiglia","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Gabriella Paparella, Medical Degree","CONTACT","+39 04389062","gabriella.paparella@lanostrafamiglia.it",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"IRCCS Eugenio Medea \u002F Associazione la Nostra Famiglia","RECRUITING","Conegliano","Treviso","31015","Italy","IT",{"type":42,"coordinates":43},"Point",[44,45],12.30201,45.88805,{"lat":45,"lon":44},[48,51],{"name":49,"role":29,"phone":30,"phoneExt":20,"email":50},"Isabella Orlando, PhD","isabella.orlando@lanostrafamiglia.it",{"name":52,"role":29,"phone":30,"phoneExt":20,"email":53},"Leonardo Boccuni, PhD","leonardo.boccuni@lanostrafamiglia.it",{"type":55,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100600251","electroencephalogram-in-patients-with-friedreichs-ataxia-for-the-study-of-the-structural-and-functional-connectome-100600251",false,"NCT07095062","Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.","Structural-Functional Connectome and High Density Electroencephalogram: Pilot Study in Patients With Friedreich's Ataxia.","CONNETTOMA","Inclusion criteria:\n\n* age between 8 and 60 years;\n* genetic diagnosis of FRDA: presence of guanine-adenine trinucleotide (GAA) expansion in the two alleles of the fratassin gene, GAA1 and GAA2;\n* score on the Scale for the Assessment and Rating of Ataxia (SARA) \\\u003C 30;\n* ability to take part in a neuropsychological assessment in Italian.\n\nExclusion criteria:\n\n* age different from the range 8-60 years;\n* diagnosis of acquired ataxia or other genetic ataxias;\n* SARA scale score ≥ 30;\n* inability to take part in an Italian-language neuropsychological assessment","ALL","8 Years","60 Years",{"count":68,"type":69},30,"ESTIMATED","INTERVENTIONAL",[72],"NA","Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG). The aim is to identify neurophysiological biomarkers and analyze the relationship between cortical connectivity, cognitive functioning, and clinical severity, particularly in response to rehabilitation treatment.",[75,76],"Friedreich's Ataxia","Motor Disorders",[78,79,80,81,82,83,84,85,86],"Functional Connectivity","HD-EEG","FRDA","Connectome","Cognitive Functioning","Neurodegenerative Disease","Cerebellar Disorders","Neurophysiological Biomarkers","Friedreich Ataxia","2025-07-23",{"date":89,"type":90},"2025-07-31","ACTUAL",{"date":92,"type":90},"2025-07-07",{"date":94,"type":69},"2026-12-31",{"name":5,"class":6},1]