[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565322":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":66,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"IRCCS San Camillo, Venezia, Italy","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"PD-MCI",null,"Parkinson's disease with Mild Cognitive Impairment",[13],"Diagnostic Test: Hd-EEG",{"label":15,"type":10,"description":16,"interventionNames":17},"PD-nMCI","Parkinson's disease without Mild Cognitive Impairment",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy control","Healthy participants matched for age and gender with the experimental groups",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Hd-EEG","Subjects undergo a clinical and neuropsychological assesment, then a Hd-EEG both during resting state and execution of tasks, and structural Magnetic Resonance Imaging",[19,9,15],[29],"MRI",[31],{"name":32,"affiliation":33,"role":34},"francesca burgio, phd","San Camillo IRCCS","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Francesca Burgio, PhD","CONTACT","+390412207536","francesca.burgio@hsancamillo.it",{"name":42,"role":38,"phone":43,"phoneExt":10,"email":44},"Giovanni Lazzaro, MSc","+3904122079598","giovanni.lazzaro@hsancamillo.it",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"IRCCS San Camillo S.R.L","RECRUITING","Lido","Italy","IT",{"type":53,"coordinates":54},"Point",[55,56],12.36649,45.4105,{"lat":56,"lon":55},[59,63],{"name":60,"role":38,"phone":61,"phoneExt":62,"email":40},"Francesca Burgio","+39 0412207536","+39",{"name":64,"role":38,"phone":65,"phoneExt":10,"email":44},"Giovanni Lazzaro","04122079598",{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100565322","electrophysiological-signature-of-mild-cognitive-impairment-and-its-relationship-with-parkinsons-disease-a-high-density-eeg-investigation-100565322",false,"NCT06640673","Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation","MMCI","Inclusion Criteria:\n\n* Upper score \\>24 MMSE or \\>15.5 Moca\n* If taking medications, taking stable doses for at least 4 weeks prior to the inclusion visit - of anticholinesterase drugs (donepezil, memantine, rivastigmine, ...) or antidepressants (SSRIs, tricyclics, SNARI, ...) or Levodopa.\n* Having signed the informed consent\n\nExclusion Criteria:\n\n* Subjects with severe dementia ( MMSE \\\u003C 24 )\n* Lower score \\\u003C15.5 Moca\n* Subjects on antipsychotic treatment for less than 3 months\n* Subjects with uncontrolled comorbidities\n* Subjects with metal prostheses or dentures and in general conditions for which MRI examinations are prevented.\n* Subjects with an inability to walk independently.",true,"ALL","50 Years","90 Years",{"count":80,"type":81},42,"ESTIMATED","OBSERVATIONAL","The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.",[85,86,87],"Parkinson Disease","Parkinson Disease, Mild Cognitive Impairment","Healthy",[89,90,91,25],"MCI in PD","Mild Cognitive Impairment","Parkinson's disease","2024-10-11",{"date":94,"type":95},"2024-10-15","ACTUAL",{"date":97,"type":95},"2023-06-18",{"date":99,"type":81},"2025-05",{"name":5,"class":6},1]