[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605771":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":44,"responsibleParty":63,"collaborators":42,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":42,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":42,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":47,"whyStopped":42,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Massachusetts Eye and Ear Infirmary","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Electrostimulation","EXPERIMENTAL","The experimental group will entail the subject wearing the electrodes on the cheeks and forehead, for 30 minutes WITH amplitude.",[13],"Device: Electrodes with Currents",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham","SHAM_COMPARATOR","The placebo group will entail the subject wearing the electrodes on the cheeks and forehead, for 30 minutes WITHOUT amplitude.",[19],"Device: Electrodes without Currents",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Electrodes with Currents","Electrodes will be placed on the cheeks and forehead, and treated with an amplitude of 300 µA for 30 mins",[9],[27],"Treatment",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Electrodes without Currents","Electrodes will be placed on the cheeks and forehead, and treated with an no amplitude for 30 mins",[15],[15],[34],{"name":35,"affiliation":5,"role":36},"Zhonghui Luo, MD, PhD","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Michael Cheung, MSc, CCRP","CONTACT","6175736060",null,"mcheung0@meei.harvard.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Massachusetts Eye and Ear - Longwood Campus","RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-71.05977,42.35843,{"lat":57,"lon":56},[60,62],{"name":39,"role":40,"phone":61,"phoneExt":42,"email":43},"617-573-6060",{"name":35,"role":36,"phone":42,"phoneExt":42,"email":42},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"SPONSOR_INVESTIGATOR","Zhonghui K. Luo, MD, PhD","Principal Investigator","100605771","electrostimulation-study-for-ocular-graft-vs-host-disease-100605771",false,"NCT07166848","Electrostimulation Study for Ocular Graft vs. Host Disease","Pilot Trial of Non-invasive Electrostimulation in Chronic Ocular Graft-vs-Host Disease","Inclusion Criteria:\n\n* Diagnosis of chronic ocular graft vs. host disease (oGVHD) (ICCGVHD criteria probable or definite)\n* OSDI score of 22 or higher\n* NEI corneal staining score (or modified NEI score) of 2 or higher.\n\nExclusion Criteria:\n\n* Patients with any open wound on the eyelid.\n* Patient with any active cornea ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma or other active pathology per PI's discretion.\n* Patient with a pacemaker or ICD.\n* Patient currently pregnant or with a potential to be pregnant during the study.\n* Patient undergoing any ocular surgical procedure (including intravitreal injections) within the past 3 months.\n* Patient undergoing any systemic surgical procedures within 2 months.\n* Patient undergoing any non-surgical eyelid procedure such as punctal plugs or punctal cautery within 1 month of study initiation.\n* Patients on cytotoxic agents, drugs that inhibit peripheral nerve regeneration (i.e. Gabapentin, Nicotine), radiation therapy, or any other therapy per PI's discretion.\n* Patients undergoing immunosuppression regimen change within 1 month of study initiation and\u002For during the study period.\n* Patient who wears contact lens of any kind","ALL","18 Years","75 Years",{"count":78,"type":79},15,"ESTIMATED","INTERVENTIONAL",[82],"NA","This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease.",[85],"Chronic Ocular Graft-versus-host Disease",[87,9],"GVHD","2025-12-09",{"date":90,"type":91},"2025-12-17","ACTUAL",{"date":93,"type":91},"2025-11-30",{"date":95,"type":79},"2029-11-30",{"name":65,"class":6},1]