[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540699":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":81,"collaborators":85,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":91,"sex":96,"minAge":97,"maxAge":10,"enrollmentInfo":98,"targetDuration":10,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Queen's University","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Emergency department patients tested for pulmonary embolism.",null,[12],"Diagnostic Test: Adjust-Unlikely",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Adjust-Unlikely","Pulmonary embolism will be excluded during emergency department assessment by the combination of:\n\n1. 'Pulmonary embolism is the most likely diagnosis' as per the treating physician AND a D-dimer result \\\u003C 500 ug\u002FL fibrinogen equivalent units;\n2. 'Pulmonary embolism is not the most likely diagnosis' AND D-dimer \\\u003C age-adjusted threshold; or,\n3. A negative computed tomography scan, planar ventilation perfusion scan or ventilation perfusion-SPECT.\n\nEmergency departments will use their local laboratory D-dimer assay.",[9],[20],{"name":21,"affiliation":22,"role":23},"Kerstin de Wit, MD","Queens University","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Natasha S Clayton","CONTACT","416-566-3590","natasha.clayton@queensu.ca",[31,51,63,72],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Hamilton Health Sciences Corporation","RECRUITING","Hamilton","Ontario","L8L 2X2","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-79.84963,43.25011,{"lat":43,"lon":42},[46,49],{"name":47,"role":27,"phone":28,"phoneExt":10,"email":48},"Natasha Clayton","claytonn@hhsc.ca",{"name":50,"role":23,"phone":10,"phoneExt":10,"email":10},"Alim Pardhan, MD",{"facility":52,"status":33,"city":53,"state":35,"zip":54,"country":37,"countryCode":38,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Kingston Health Sciences Centre","Kingston","K7L 2V7",{"type":40,"coordinates":56},[57,58],-76.48098,44.22976,{"lat":58,"lon":57},[61,62],{"name":47,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":21,"role":23,"phone":10,"phoneExt":10,"email":10},{"facility":64,"status":65,"city":66,"state":35,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":67,"geoPoint":71,"contacts":10},"London Health Sciences Centre Research Inc","ACTIVE_NOT_RECRUITING","London",{"type":40,"coordinates":68},[69,70],-81.23304,42.98339,{"lat":70,"lon":69},{"facility":73,"status":65,"city":74,"state":35,"zip":75,"country":37,"countryCode":38,"cosmosGeoPoint":76,"geoPoint":80,"contacts":10},"Ottawa Hospital Research Institute","Ottawa","K1Y 4E9",{"type":40,"coordinates":77},[78,79],-75.69812,45.41117,{"lat":79,"lon":78},{"type":82,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dr. Kerstin de Wit","Clinician Investigator Program Director & Research Director for the Department of Emergency Medicine, Queen's University",[86],{"name":87,"class":88},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100540699","emergency-medicine-pulmonary-embolism-testing-multicentre-study-100540699",false,"NCT06320236","Emergency Medicine Pulmonary Embolism Testing Multicentre Study","EMPET","Inclusion Criteria:\n\n* Emergency department patient who is tested by an emergency physician for PE\n\nExclusion Criteria:\n\n* Patient is \\\u003C 18 years of age\n* No documentation of whether PE is the most likely diagnosis\n* D-dimer is not tested or else not resulted during the emergency visit\n* The D-dimer level is known before documentation of whether PE is the most likely diagnosis\n* The D-dimer is ordered prior to the physician assessing the patient\n* The patient has previously registered that they opt out of all research at the participating site\n* The patient leaves against medical advice\n* The patient has had PE or deep vein thrombosis imaging (CT pulmonary angiogram, ventilation-perfusion scan or lower limb ultrasound) within prior 30 days\n* There is a new (non-PE) indication for anticoagulation\n* The patient was initiated on treatment for presumed PE prior to PE testing\n* The patient has previously been enrolled into the study\n* The patient has a prior history of lower extremity deep vein thrombosis without availability of a baseline ultrasound scan\n* The patient was transferred from another hospital organization\n* The patient does not reside in Ontario\n* The patient has no valid Ontario Health Insurance Plan card","ALL","18 Years",{"count":99,"type":100},4000,"ESTIMATED","OBSERVATIONAL","It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging.\n\nA new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results.\n\nThe study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.",[104,105,106],"Pulmonary Embolism","D-dimer","Diagnosis",[105,104,16,108,109],"Diagnostic","Emergency Medicine","2026-04-15",{"date":112,"type":113},"2026-04-20","ACTUAL",{"date":115,"type":113},"2024-01-01",{"date":117,"type":100},"2027-09-30",{"name":83,"class":6},4]