[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632444":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Hospital, Ghent","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patient group",null,"People who have a current or past history of anxiety and\u002For depression",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy control group","People who do not have a current or past history of anxiety and\u002For depression",[16],{"name":17,"affiliation":18,"role":19},"Chris Baeken","University Ghent","PRINCIPAL_INVESTIGATOR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+32476209841","Chris.Baeken@ugent.be",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Sara De Witte","+32498382824","sara.dewitte@ugent.be",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University Hospital Ghent, Ghent, East-Flanders 9000","RECRUITING","Ghent","9000","Belgium","BE",{"type":38,"coordinates":39},"Point",[40,41],3.71667,51.05,{"lat":41,"lon":40},[44,45],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100632444","emotion-regulation-in-rnt-100632444",false,"NCT07513766","Emotion Regulation in RNT","The Neural Mechanisms of Emotion Dysregulation in Repetitive Negative Thinking (RNT) Patients: A Pilot Study","Inclusion Criteria:\n\n* Patient group: diagnosis of depression\u002FGAD\n* Healthy control group: no history of or current form of psychopathology",true,"ALL","18 Years","65 Years",{"count":60,"type":61},100,"ESTIMATED","OBSERVATIONAL","The goal of this study is to understand why some people become stuck in repetitive negative thinking, which is common among individuals with depression and anxiety. Repetitive negative thinking involves repeatedly focusing on negative events, worries, or problems. These thoughts can be difficult to control and may worsen emotional distress and daily functioning.\n\nResearchers believe that repetitive negative thinking may be related to changes in how different brain networks communicate with each other. This study will examine how the brain responds during emotion regulation tasks in people who tend to ruminate compared with healthy individuals.\n\nTo do this, researchers will use a brain-imaging technique called functional near-infrared spectroscopy (fNIRS). This method measures brain activity using harmless infrared light while participants perform tasks on a computer.\n\nThe main questions this study aims to answer are:\n\nHow does the brain respond to emotional situations in people who experience repetitive negative thinking?\n\nAre there differences in brain activity between people with depression or anxiety and healthy individuals during emotion regulation?\n\nParticipants will include 50 healthy volunteers and 50 individuals with depression or anxiety who experience repetitive negative thinking.\n\nParticipants will:\n\nWear a lightweight brain-imaging device (fNIRS) placed on the head to measure brain activity\n\nComplete computer tasks involving emotional images and different emotion-regulation strategies, such as reinterpreting, suppressing, or distracting from emotions\n\nListen to different types of spoken feedback (criticism, praise, or neutral comments) and imagine receiving them from someone they know\n\nReport their emotional feelings during the tasks\n\nComplete several questionnaires about mood, thinking patterns, and emotional experiences\n\nDuring the experiment, researchers will also record physiological responses such as heart activity and skin reactions, which are related to emotional responses.\n\nThe results of this study may help researchers better understand the brain mechanisms underlying rumination and may contribute to the development of more effective treatments for depression and anxiety.",[65,66],"Repetitive Negative Thinking","Healthy Controls Group - Age and Sex-matched",[68,69,70],"Repetitive negative thinking","fnirs","emotion regulation","2026-03-30",{"date":73,"type":74},"2026-04-07","ACTUAL",{"date":76,"type":74},"2024-06-05",{"date":78,"type":61},"2026-12-30",{"name":5,"class":6},1]